Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective δ opioid agonists, based on an extension of the message-address concept

Journal of Medicinal Chemistry

Volumn 40, Issue 20, 1997, Pages 3192-3198

  Dondio, Giulio ^a   Ronzoni, Silvano ^a   Eggleston, Drake S ^a,b   Artico, Marco ^a   Petrillo, Paola ^a   Petrone, Giuseppe ^a   Visentin, Luciano ^a   Farina, Carlo ^a   Vecchietti, Vittorio ^a   Clarke, Geoffrey D ^a  

^a SmithKline Beecham SpA   (Italy)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(DIETHYLAMINO)CARBONYL] 6 ETHYL 8A (3 HYDROXYPHENYL) 3 METHYL 4,4A,5,6,7,8,8A OCTAHYDRO 1H PYRROLO[2,3 G]ISOQUINOLINE; 2 [(DIETHYLAMINO)CARBONYL] 6 ETHYL 8A (3 HYDROXYPHENYL) 3 METHYL 4,4A,5,6,7,8,8A,9 OCTAHYDRO 1H PYRROLO[2,3 G]ISOQUINOLINE; 4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; DELTA OPIATE RECEPTOR AGONIST; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BIOASSAY; BRAIN MEMBRANE; CANCER CELL CULTURE; COMPUTER MODEL; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MEMBRANE BINDING; MOLECULAR MODEL; MOUSE; NONHUMAN;

ANIMALS; BENZAMIDES; BRAIN; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENKEPHALIN, LEUCINE-2-ALANINE; INDOLES; ISOQUINOLINES; LIGANDS; MALE; MICE; MODELS, MOLECULAR; NALTREXONE; NARCOTIC ANTAGONISTS; NOCICEPTORS; PIPERAZINES; PYRROLES; QUINOLINES; RECEPTORS, OPIOID, DELTA; SIGNAL TRANSDUCTION; STEREOISOMERISM; VAS DEFERENS;

EID: 9844261704     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9608218     Document Type: Article

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