A new diketopiperazine tetra-carboxylic acid as template for the homogeneous phase synthesis of chemical libraries

Tetrahedron Letters

Volumn 38, Issue 26, 1997, Pages 4663-4666

  Falorni, Massimo ^a   Giacomelli, Giampaolo ^a   Nieddu, Francesco ^a   Taddei, Maurizio ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PIPERAZINEDIONE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY;

EID: 0030965717     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00961-1     Document Type: Article

References (19)

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4. c) Barret, R.W.; Dower W.J.; Fodor, S.P.A.; Gordon, E.M.; Gallop, M.A. J. Med. Chem 1994, 37, 1233 and 1385. Rohr, J. Angew. Chem. Int. Ed. Engl. 1995, 34, 881.
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13. Although possible in principle, in this communication we do not report on the application of this template to a split and recombine strategy.
14. Our diketopiperazine template should permit the creation of a population of semirigid molecular arrays, comprising structural families that collectively sample as completely as possible all regions of conformational space (E.M. Gordon in ref. 1c).
15. Fisher, E.; Koenigs, E.; Chem. Ber. 1907, 40, 2048
16. The four carboxylic groups of template were named as the four cardinal points and their symbol is used through this communication
17. The authors don't have the facility of a MS-MS high resolution spectrometer employed in similar cases.
18. The purification can be accomplished also in a sealed vial by aspiration of the solvent using a syringe and subsequent cycles of washing and syringe aspiration.
19. We noted sometimes that, at the TLC analysis, traces of by-products were present. Even with major changes of the procedure we were not able to avoid their incidental formation.