Novel scaffolds for non-peptide mimetics of δ opioid receptor agonists based on peptide leads

Regulatory Peptides

Volumn 65, Issue 1, 1996, Pages 79-82

  Qian, Xinhua ^a   Liao, Subo ^a   Stropova, Dagmar ^b   Yamamura, Henry I ^b   Hruby, Victor J ^a  

^a University of Arizona ^*  (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR; OPIATE AGONIST;

ANALGESIA; ANIMAL CELL; CONTROLLED STUDY; DRUG DESIGN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

ANIMALIA;

EID: 0030603857     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-0115(96)00075-4     Document Type: Article

References (11)

1. [1] Porreca, F., Bilsky, E.J. and Lai, J., Pharmacological Characterization of opioid δ and κ receptors. In: T.F. Tseng (Ed.), The Pharmacology of Opioid Peptides, Harwood Academic Publisher, New York, 1995, pp. 219-238.
2. [2] Chang, K.-J., Rigdon, G.C., Howard, J.L. and McNutt, R.W., A Novel, Potent and selective nonpeptidic delta opioid receptor agonist BW373U86, J. Pharmacol. Exp. Ther., 267 (1993) 852-857.
3. [3] Calderon, S.N., Rothman, R.B., Porreca, F., Flippen-Anderson, J.L., McNutt, R.W., Xu, H., Smith, L.E., Bilsky, E.J., Davis, P. and Rice, K.C., Probes for Narcotic Receptor Mediated Phenomena. 19. Synthesis of (+)-4-[α R)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinylbenzamide (SNC 80): A highly selective, nonpeptide δ opioid receptor agonist, J. Med. Chem., 37 (1994) 2125-2128.
4. 2, J. Med. Chem., 38 (1995) 585-586.
5. [5] Qian, X., Kövér, K.E., Shenderovich, M.D., Bilsky, E.J., Bernstein, R.N., Lou, B.-S., Horváth, R., Zalewska, T., Davis, P., Porreca, F., Yamamura, H.I. and Hruby, V.J., Topographical design of message domain pharmacophores of δ opioid receptor subtypes. In: J. Lu and J.P. Tam (Eds.), Peptides: Proceedings of the Chinese Peptide Symposium, 1994, ESCOM Sci. Publ. Leiden, 1996, in press.
6. [6] Qian, X., Kövér, K.E., Shenderovich, M.D., Misicka, A., Zalewska, T., Horváth, R., Davis, P., Porreca, F., Yamamura, H.I. and Hruby, V.J., Newly discovered stereochemical requirements in side chain conformations of δ opioid agonists for recognizing opioid δ receptors, J. Med. Chem., 37 (1994) 1746-1757.
7. [7] Qian, X., Ph.D. Dissertation, University of Arizona, Tucson, AZ, 1995.
8. 5]enkephalin by NMR spectroscopy and conformational energy calculations, Biopolymers, 38 (1996) 141-156.
9. [9] Nikiforovich, G.V., Hruby, V.J., Prakash, O. and Gehrig, C.A., Topographical requirements for δ-selective opioid peptides, Biopolymers, 31 (1991) 941-955.
10. [10] Rónai, A.Z., Botyánszki, J., Magyar, A., Borsodi, A., Benyhe, S. and Medzihradszky, K., Novel, δ-Opioid Receptor-selective peptide antogonists: Demonstration of a possible opioid interaction in the absence of a protonated nitrogen and attempts to locate the protonated nitrogen site, Arch. Int. Pharmacodyn., 323 (1993) 114-125.
11. [11] Allen, F.H., Davies, J.E., Galloy, J.J., Johnson, O., Kennard, O., Macrae, C.F., Mitchell, E.M., Mitchell, G.F., Smith, J.M. and Watson, D.G., The development of version 3 and 4 of the Cambridge Structural Database System, J. Chem. Inf. Comp. Sci., 31 (1991) 187-204.