The stabilization mechanism of mutant-type p53 by impaired ubiquitination: The loss of wild-type p53 function and the hsp90 association

Oncogene

Volumn 18, Issue 44, 1999, Pages 6037-6049

  Nagata, Yoichi ^a,b   Anan, Tadashi ^a   Yoshida, Tetsuo ^c   Mizukami, Tamio ^c   Taya, Yoichi ^d   Fujiwara, Toshiyoshi ^e   Kato, Hirohisa ^b   Saya, Hideyuki ^a   Nakao, Mitsuyoshi ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYOWA HAKKO KOGYO CO LTD   (Japan)

^d NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^e OKAYAMA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Conformation; hsp90; mdm2; p53; Phosphorylation; Ubiquitin proteasome

Indexed keywords

GELDANAMYCIN; HEAT SHOCK PROTEIN 90; MUTANT PROTEIN; PROTEASOME; PROTEIN P53; UBIQUITIN;

ARTICLE; CANCER CELL; CODON; CONTROLLED STUDY; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; MUTATION RATE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; TWO DIMENSIONAL GEL ELECTROPHORESIS;

AMINO ACID SEQUENCE; ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; BONE NEOPLASMS; CYSTEINE ENDOPEPTIDASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTATION; OSTEOSARCOMA; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CONFORMATION; QUINONES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINS;

EID: 0033613434     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202978     Document Type: Article

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