The pro-protein convertase PC1 is induced in the transected sciatic nerve and is present in cultured Schwann cells: Comparison with PC5, furin and PC7, implication in pro-BDNF processing

Molecular Brain Research

Volumn 59, Issue 2, 1998, Pages 229-246

  Marcinkiewicz, Mieczyslaw ^a   Savaria, Diane ^a   Marcinkiewicz, Jadwiga ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

BDNF; Cell culture; Immunocytochemistry; In situ hybridization; NGF; Northern blot; Vaccinia virus infection; Western blot

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; FURIN; MESSENGER RNA; NERVE GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NERVE CELL CULTURE; NERVE TRANSECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SCHWANN CELL; SCIATIC NERVE;

ANIMALS; ASPARTIC ENDOPEPTIDASES; BIOLOGICAL MARKERS; BLOTTING, NORTHERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARCINOGENS; CELLS, CULTURED; DENERVATION; FORSKOLIN; FURIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IN SITU HYBRIDIZATION; IONOMYCIN; IONOPHORES; MALE; NERVE GROWTH FACTORS; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 5; PROPROTEIN CONVERTASES; PROTEIN PRECURSORS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SCHWANN CELLS; SCIATIC NERVE; SERINE ENDOPEPTIDASES; SUBTILISINS; TETRADECANOYLPHORBOL ACETATE; VACCINIA;

ANIMALIA; VACCINIA; VACCINIA VIRUS;

EID: 0032584937     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00141-7     Document Type: Article

References (42)

1. Acheson A., Barker P.A., Alderson R.F., Miller F.D., Murphy R.A. Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: inhibition by antibodies to NGF. Neuron. 7:1991;265-275.
2. Bandtlow C.E., Heumann R., Schwab M.E., Thoenen H. Cellular localization of nerve growth factor synthesis by in situ hybridization. EMBO J. 6:1987;891-899.
3. Barde Y.-A., Edgar D., Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1:1982;549-553.
4. Basak A., Boudreault A., Chen A., Chrétien M., Seidah N.G., Lazure C. Application of the multiple antigenic peptides (MAP) strategy to the production of prohormone convertases antibodies: synthesis, characterization and use of 8-branched immunogenic peptides. J. Pept. Sci. 1:1995;385-395.
5. Benjannet S., Savaria D., Laslop A., Munzer J.S., Chrétien M., Marcinkiewicz M., Seidah N.G. α1-Antitrypsin-Portland inhibits processing of precursors mediated by pro-protein convertases primarily within the constitutive pathway. J. Biol. Chem. 272:1997;26210-26218.
6. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal. Biochem. 72:1976;238-254.
7. Bresnahan P.A., Leduc R., Thomas L., Thorner J., Gibson H.J., Brake A.J., Barr P.J., Thomas G. Human fur gene encodes a yeast Kex2-like endoprotease that cleaves pro-β-NGF in vivo. J. Cell Biol. 111:1990;2851-2859.
8. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques. 15:1993;532-537.
9. Coates L.C., Birch N.P. Posttranslational maturation of the prohormone convertase SPC3 in vitro. J. Neurochem. 68:1997;828-836.
10. de Bie I., Marcinkiewicz M., Malide D., Lazure C., Nakayama K., Bendayan M., Seidah N.G. The isoforms of the pro-protein convertase PC5 are sorted to different subcellular compartments. J. Cell Biol. 135:1996;1261-1275.
11. Edwards R.H., Selby M.J., Garcia P.D., Rutter W.J. Processing of the native nerve growth factor precursor to form biologically active nerve growth factor. J. Biol. Chem. 263:1988;6810-6815.
12. Friede R.L., Johnstone M.A. Responses of thymidine labeling of nuclei in gray matter and nerve following sciatic transection. Acta Neuropathol. 7:1967;218-231.
13. Heumann R., Korsching S., Bantlow C., Thoenen H. Changes of nerve growth factor synthesis in neuronal cell in response to sciatic nerve transection. J. Cell Biol. 104:1989;1623-1631.
14. Heumann R., Lindholm D., Bentlow C., Meyer M., Radeke M.J., Misko T.P., Shooter E., Thoenen H. Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration and regeneration: role of macrophages. Proc. Natl. Acad. Sci. USA. 84:1987;8735-8739.
15. Hohn A., Leibrock J., Bailey K., Barde Y.-A. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature. 344:1990;339-341.
16. Hornby P.J., Rosenthal S.D., Mathis O., Vindrola O., Lindberg I. Immunocytochemical localization of the neuropeptide-synthesizing enzyme PC1 in AtT-20 cells. Neuroendocrinology. 58:1993;555-563.
17. Leibrock J., Lottspeich F., Hohn A., Hofer M., Hengerer B., Masiakowski P., Thoenen H., Barde Y.-A. Molecular cloning and expression of brain-derived neurotrophic factor. Nature. 341:1989;149-152.
18. Levi-Montalcini R. The nerve growth factor: its mode of action on sensory and sympathetic nerve cells. Harvey Lect. 60:1966;217-259.
19. Maisonpierre P.C., Belluscio L., Squinto S., Ip N.Y., Furth M.E., Lindsay R.M., Yancopoulos G.D. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science. 247:1990;1446-1451.
20. M. Marcinkiewicz, J. Marcinkiewicz, A. Chen, F. Leclaire, M. Chrétien, P. Richardson, NGF and pro-protein convertases furin and PC7 in transected sciatic nerves and in nerve segments cultured in conditioned media: their presence in Schwann cells, macrophages and smooth muscle cells, J. Comp. Neurol., in press.
21. Marcinkiewicz M., Nagao T., Day R., Seidah N.G., Chrétien M., Avoli M. Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression. Neuroscience. 76:1997;425-439.
22. Marcinkiewicz M., Ramla D., Seidah N.G., Chrétien M. Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets. Endocrinology. 135:1994;1651-1660.
23. Marcinkiewicz M., Seidah N.G., Chrétien M. Les convertases des prohormones et le système nerveux. Médecine/Sciences. 9:1993;553-561.
24. Marcinkiewicz M., Seidah N.G., Chrétien M. Implication of the subtilisin/kexin-like precursor convertases in the development and function of nervous tissues. Acta Neurobiol. Exp. 56:1996;287-298.
25. Marcinkiewicz M., Touraine P., Mbikay M., Chrétien M. Expression of neuroendocrine secretory protein 7B2 mRNA in the mouse and rat pituitary gland. Neuroendocrinology. 58:1993;86-93.
26. Matsuoka I., Meyer M., Thoenen H. Cell-type-specific regulation of nerve growth factor (NGF) synthesis in non-neuronal cells: comparison of Schwann cells with other cell types. J. Neurosci. 11:1991;3165-3177.
27. Meyer A., Chrétien P., Massicotte G., Sargent C., Chrétien M., Marcinkiewicz M. Kainic acid increases the expression of the prohormone convertases furin and PC1 in the mouse hippocampus. Brain Res. 732:1996;121-132.
28. Meyer M., Matsuoka I., Wetmore C., Olson L., Thoenen H. Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J. Cell Biol. 119:1992;45-54.
29. Molloy S.S., Thomas L., VanSlyke J.K., Stenberg P.E., Thomas G. Intracellular trafficking and activation of the furin pro-protein convertase: Localization to the TGN and recycling from the cell surface. EMBO J. 13:1994;18-33.
30. Muir D., Genrich C., Varon S., Manthorpe M. Rat sciatic nerve Schwann cell microcultures: responses to mitogens and production of trophic and neurite-promoting factors. Neurochem. Res. 14:1989;1003-1012.
31. Plant G.W., Harvey A.R., Chirila T.V. Axonal growth within poly (2-hydroxyethyl metacrylate) sponges infiltrated with Schwann cells and implanted into lesioned rat optic tract. Brain Res. 671:1995;119-130.
32. Richardson P., Ebendal T. Nerve growth activities in rat peripheral nerve. Brain Res. 246:1982;57-64.
33. Schäfer W., Stroh A., Berghöfer S., Seiler J., Vey M., Kruse M.-L., Kern H.F., Klenk H.D., Garten W. Two independent targeting signals in thew cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the pro-protein convertase furin. EMBO J. 14:1995;2424-2435.
34. N.G. Seidah, The mammalian family of subtilisin/kexin-like pro-protein convertases, in: U. Shinde, M. Inouye (Eds.), Intramolecular Chaperones and Protein Folding, R.G. Landes, Austin, TX, 1995, pp. 181-203.
35. Seidah N.G., Benjannet S., Pareek S., Chrétien M., Murphy R.A. Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian pro-protein convertases. FEBS Lett. 379:1996;247-250.
36. Seidah N.G., Benjannet S., Pareek S., Savaria D., Hamelin D., Goulet B., Laliberté J., Lazure C., Chrétien M., Murphy R.A. Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases. Biochem J. 314:1996;951-960.
37. Seidah N.G., Day R., Marcinkiewicz M., Chrétien M. Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins. Ann. NY Acad. Sci. 839:1998;9-24.
38. Seidah N.G., Hamelin J., Mamarbachi M., Dong W., Tadros H., Mbikay M., Chrétien M., Day R. cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian pro-protein convertase closest to yeast kexin-like proteinases. Proc. Natl. Acad. Sci. USA. 93:1996;3388-3393.
39. Suter U., Heymach J.V., Shooter E.M. Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of the correctly processed and biologically active NGF. EMBO J. 10:1991;2395-2400.
40. Thoenen H., Barde Y.-A. Physiology of nerve growth factor. Physiol. Rev. 60:1980;1284-1335.
41. Ullich A., Gray A., Berman C., Dull T.J. Human β-nerve growth factor gene sequence highly homologous to that of mouse. Nature. 303:1983;821-825.
42. Watabe K., Fukuda T., Tanaka J., Honda H., Toyohara K., Sakai O. Spontaneously immortalized adult mouse Schwann cells secrete autocrine and paracrine growth-promoting activities. J. Neurosci. Res. 41:1995;279-290.