Development of polymer-supported benzotriazole as a novel traceless linker for solid-phase organic synthesis

Journal of Organic Chemistry

Volumn 64, Issue 13, 1999, Pages 4972-4975

  Schiemann, Kai ^a,b   Showalter, H D Hollis ^a  

^a PFIZER INC   (United States)

^b MERCK KGAA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOTRIAZOLE DERIVATIVE;

ALKYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; DRUG SYNTHESIS; ELECTRON TRANSPORT; POLYMERIZATION; SOLID PHASE EXTRACTION;

EID: 0033603380     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo990203+     Document Type: Article

References (30)

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27. We also synthesized a congener of 2 from ArgoPore-Cl Memfield resin (poly(ethylene glycol)-polystyrene graft copolymer, 120-230 μm, 1.26 mmol/g Cl) in the same two-step sequence of reactions starting from 11. Because of the lower loading of the starting resin, the loading of ArgoPore-benzotriazole 2 never exceeded 0.78 mmol/g. The physical properties of this resin are outstanding, and its application toward the synthesis of Mannich-type adducts gave results similar to 2.
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30. Besides the solvents listed in Table 1, resin 1 was found to exhibit very poor swelling properties in benzene, chloroform, diethyl ether, and methanol.