Linkers for solid-phase organic synthesis

Current Opinion in Drug Discovery and Development

Volumn 1, Issue 1, 1998, Pages 59-65

  Morphy, John Richard ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0003178552     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

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28. Gayo LM, Suto MJ: Traceless linker: Oxidative activation and displacement of a sulfur based linker. Tetrahedron Lett (1997)38:211-214. An activatable traceless linker system fora nitrogen heterocycle.
29. Halm C, Evarts J, Kurth MJ: Polymer bound allylic sulphones in a solid-phase route to trisubstituted olefins. Tetrahedron Lett (1997) 38:7709-7712. A trace/ess/inker system for trisubstituted olefins.
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32. Conti P, Demont D, Gals J, Ottenheijm HCJ, Leysen D: A new cleavage strategy for the solid-phase synthesis of secondary amines. Tetrahedron Lett CO'37) 38:2915-2918. A linker for secondary amines with unusually high chemical stability.
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38. Schuster M, Lucas N, Blechort S: Ruthenium catalyzed cross metathesis binding of functionalised olefins to polystyrene resin via a novel allylsilyl linker suitable for electrophilic cleavage. Chem Commun (1997) 823-824.
39. Nicolaou KG, Vourloumis D, Li T, Pastor J: Designed Epothilones: Combinatorial synthesis, tubulin assembly properties and cytotoxic action against taxol resistant tumor cells. Angew Chemie lntEd(\Q°iJ) 36:2097-2103. An example of the synthesis of complex natural product analogs by ring closing metathesis on the solid-phase.
40. Piscopio AD, Miller JF, Koch K: Solid-phase heterocyclic synthesis via ring closing metathesis. Tetrahedron Lett (1997)38:7143-7146. Several different types of cyclic olefin are synthesized on a resin.
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44. Whitehouse DL, Nelson KH, Savinov SN, Austin DJ: A chemoselective rhodium (2) mediated solid-phase 1,3-dipolar cycloaddition and its application to a thermally self-cleaving furan scaffold. Tetrahedron Lett (1997) 38:7139-7142.
45. Allin SM, Shuttleworth SJ: The preparation and first application of a polymer supported Evans oxazolidinone. Tetrahedron Lett (1996) 37: 8023-8026. The first report of the use of an Evans oxazolidinone as a chiral linker.
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47. Burgess K, Lim D: Resin type can have Important effects on solid-phase asymmetric alkylation reactions. Chem Commun (1997) 785-786.