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Compound 3a (PS-DES resin) is commercially available from Argonaut Technologies
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Compound 3a (PS-DES resin) is commercially available from Argonaut Technologies.
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34
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84988201425
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85034474585
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note
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-1 for compound 5 (dialkylsilane) and could be used for evaluation of reaction progress.
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38
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0029841253
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For a recent review of silyl ether protecting groups, see: Nelson, T. D.; Crouch, R. D. Synthesis 1996, 1031.
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85034485983
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note
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Other chlorinating reagents include trichloroisocyanuric acid, N-chlorosuccinimide, and trityl chloride. These chlorination methods were found to be inferior to 1,3-dichloro-5,5-dimethylhydantoin either because of the formation of insoluble byproducts or requirement for longer reaction times.
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