Soluble polymer traceless linker investigations: Solvent effects on the desulfonylation of polyethylene glycol (PEG) substituted aryl alkyl sulfones with sodium amalgam

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 18, 1998, Pages 2439-2442

  Zhao, Xu Yang ^a   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMALGAM; MACROGOL; SULFONE DERIVATIVE;

ARTICLE; MOLECULAR DYNAMICS; POLYMERIZATION; REACTION ANALYSIS; SOLUBILITY; SYNTHESIS;

ALLOYS; MERCURY COMPOUNDS; MODELS, CHEMICAL; POLYETHYLENE GLYCOLS; POLYMERS; SOLVENTS; SULFONES;

EID: 0032558521     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00441-7     Document Type: Article

References (9)

1. 1. (a) Plunkett, M. J.; Ellman, J. A. J. Org. Chem. 1995, 60, 6006.
2. (b) Chenera, B.; Finkelstein, J. A.; Veber, D. F. J. Am. Chem. Soc. 1995, 117, 11999.
3. 2. Zhao, X.; Janda, K. D. Tetrahedron Lett. 1997, 38, 5437.
4. 3. Zhao, X.; Jung, K. W.; Janda, K. D. Tetrahedron Lett. 1997, 38, 977.
5. 2O (30 mL), and filtered through silica gel. The filtrate was evaporated, and further dried under vacuum to give 5 (7.5 mg, 97%).
6. 5. (a) Han, H; Wolfe, M. M; Brenner, S; Janda, K. D. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 6419.
7. (b) Han, H; Janda, K. D. J. Am. Chem. Soc. 1996, 118, 2539.
8. (c) Han, H; Janda, K. D. Angew. Chem. Int. Ed. Engl. 1997, 36, 1731.
9. (d) Gravert, D. J.; Janda, K. D. Chem. Rev. 1997, 97, 489.