Inhibition of human immunodeficiency virus type 1 infection in a T-cell line (CEM) by new dipeptidyl-peptidase IV (CD26) inhibitors

Research in Virology

Volumn 148, Issue 4, 1997, Pages 255-266

  Jiang, J D ^a   Wilk, S ^b   Li, J ^b   Zhang, H ^a   Bekesi, J G ^a,b  

^a Department of Medicine   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

CEM cells; Dipeptidyl peptidase IV; DPP IV CD26; Entry process; HIV; Nitrile inhibitors; T lymphocyte

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ARGINYL (2,2,5,7,8 PENTAMETHYLCHROMAN 6 SULPHONYL) PYRROLIDINE 2 NITRILE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GAG PROTEIN; OKT 4; PHENYLALANYLPYRROLIDINE 2 NITRILE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INHIBITION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030738451     PISSN: 09232516     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2516(97)88362-8     Document Type: Article

References (57)

1. Alizon, M. & Dragic, T. (1994), CD26 antigen and HIV fusion? Science, 264, 1161-1162.
2. Alkhatib, G., Combadiere, C., Broder, C.C., Feng, Y., Kennedy, P.E., Murphy, P.M. & Berger, E.A. (1996), CC CKR5: A RANTES, MIP-1a, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science, 272, 1955-1959.
3. Ashworth, D.M., Atrash, B., Baker, G.R., Baxter, A.J., Jenkins, P.D., Jones, D.M. & Szelke, M. (1996a), 2-Cyanopyrrolidides as potent, stable inhibitors of dipeptidyl peptidase IV. Bioorg. Med. Chem. Lett., 6 (10), 1163-1166.
4. Ashworth, D.M., Atrash, B., Baker, G.R., Baxter, A.J., Jenkins, D.J., Jones, D.M. & Szelke, M. (1996b), 4-Cyanopyrrolidides as very potent, stable inhibitors of dipeptidyl peptidase IV. Bioorg. Med. Chem. Lett., 6 (10), 2745-2748.
5. Broder, C.C., Nussbaum, O., Gutheil, W.G., Bachovchin, W.W. & Berger, E.A. (1994), CD26 antigen and HIV fusion? Science, 264, 1156-1159.
6. + cells. Science, 262, 2045-2049.
7. Callebaut, C., Jacotot, E., Krust, B. & Hovanessian, A.G. (1994), CD26 antigen and HIV fusion? Science, 264, 1162-1165.
8. Callebaut, C. & Hovanessian, A.G. (1996), CD26 and HIV infection. Res. Virol., 147, 67-69.
9. Camerini, D., Planelles, V. & Chen, I.S.V. (1994), CD26 antigen and HIV fusion? Science, 264, 1160-1161.
10. Cann, A.J., Churcher, M.J., Boyd, M., O'Brien, W., Zhao, J.Q., Zack, J. & Chen, I.S.Y. (1992), The region of the envelope gene of HIV responsible for determination of cell tropism. J. Virol., 66, 305-309.
11. Chin, L.T., Duenas, M., Levi, M., Hinkula, J., Wahren, B. & Borrebaeck, C.A. (1995), Molecular characterization of a human anti-HIV 1 monoclonal antibody revealed a CD26-related motif in CDR2. Immunol. Lett., 44(1), 25-30.
12. Coburn, M.C., Hixson, D.C. & Reichner, J.S. (1994), In vitro immune responsiveness of rats lacking active dipeptidyl peptidase IV. Cell. Immunol., 158, 269-280.
13. + T cells. Science, 270, 1811-1815.
14. Dalgleish, A.G., Beverley, P.C.L., Clapham, P.R., Crawford, D.H., Greaves, M.F. & Weiss, R.A. (1984), The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature (Lond.), 312, 763-767.
15. Dalgleish, A. (1995), HIV and CD26. Nat. Med., 1(9), 881-882.
16. Darmoul, D., Lacasa, M., Baricault, L., Marguet, D., Sapin, C., Trotot, P., Barbat, A. & Trugnan, G. (1992), Dipeptidyl peptidase IV (CD26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. J. Biol. Chem., 267, 4824-4833.
17. Dean, M., Carrington, M., Winkler, C., Huttley, G.A., Smith, M.W., Allikmets, R., Goedert, JJ., Buchbinder, S.P., Vittinghoff, E., Gomperts, E., Donfield, S., Vlahov, D., Kaslow, R., Saah, A., Rinaldo, C., Detels, R., Hemophilia growth and development study, Multicenter AIDS Cohor Study, Multicenter Hemophilia Cohor Study, San Francisco City.
18. Cohor, ALIVE Study & O'Brient, S.J. (1996), Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science, 273, 1856-1862.
19. Deng, H.K., Lui, R., Ellimeier, W., Choe, S., Unutmaz, D., Burkhart, M., Marzio, P.D., Marmon, S., Sutton, R.E., Hill, C.M., Davis, C.B., Peiper, S.C., Schall, T.J., Littman, D.R. & Landau, N.R. (1996), Identification of a major co-receptor for primary isolates of HIV-1. Nature (Lond.), 381, 661-666.
20. + cells is mediated by the chemokine receptor CC-CKR-5. Nature (Lond.), 381, 667-673.
21. Fantini, J., Yahi, N., Delezay, O. & Gonzalez-Scarano, F. (1994), GalCer, CD26 and HIV infection of intestinal epithelial cells. AIDS, 8, 1347-1348.
22. Fecondo, J.V., Pavuk, N.C., Silburn, K.A., Read, D.M.Y., Mansell, A.S., Boyd, A.W. & McPhee, D.A. (1993), Synthetic peptide analogs of intercellular adhesion molecule 1 (ICAM-1) inhibit HIV-1 replication in MT-2 cells. AIDS Res. Hum. Retroviruses, 9(8), 733-740.
23. Feng, Y., Broder, C.C., Kennedy, P.E. & Berger, E.A. (1996), HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science, 272, 872-877.
24. Fleischer, B. (1994), CD26: a surface protease involved in T-cell activation. Immunol. Today, 15, 180-184.
25. + T-cell subset during HIV infection. Res. Immunol., 147, 5-8.
26. Hattori, T., Koito, A., Takatsuki, K., Kido, H. & Katunuma, N. (1989), Involvement of tryptase-related cellular protease(s) in human immunodeficiency virus type 1 infection. FEBS lett., 248, 48-52.
27. Hoffman, A.D., Banapour, B. & Levy, J.A. (1985), Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its determination in virions. Virology, 147, 326-335.
28. Jacotot, E., Callebaut, C.C., Blanco, J., Krust, B., Neubert, K., Barth, A. & Hovanessian, A.G. (1996a), Dipeptidyl-peptidase IV-β, a novel form of cell-surface-expressed protein with dipeptidyl-peptidase IV activity. Eur. J. Biochem., 239, 248-258.
29. + T cells. Virology, 223, 318-330.
30. Kato, T., Nagatsu, T., Kimura, T. & Sakakibara, S. (1978), Studies on substrate specificity of X-Y-p-nitroanilides. Experientia, 34, 319-320.
31. Knapp, W., Rieber, P., Dorken, B., Schmidt, R.E., Stein, H. & Borne, A.E.G. Kr.v.d. (1989), Towards a better definition of human leukocyte surface molecules. Immunol. Today, 10, 253-257.
32. Kubota, T., Flentke, G.R., Bachovin, W.W. & Stollar, B.D. (1992), Involvement of dipeptidyl peptidase IV in an in vivo immune response. Clin. Exp. Immunol., 89, 192-197.
33. Li, J.R., Wilk, E. & Wilk, S. (1995), Aminoacylpyrrolidine-2-nitriles: potent and stable inhibitors of dipeptidyl-peptidase IV (CD26). Arch. Biochem. Biophys., 323(1), 148-154.
34. Maddon, P.J.H., Dalgleish, A.G., McDougal, J.S., Clapham, P.R., Weiss, R.A. & Axel, R. (1986), The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell, 47, 333-348.
35. Mann, D.L., Read-Connole, E., Arthur, L.O., Robery, W.G., Wernet, P., Schneider, E.M., Blattner, W.A. & Popovic, M. (1988), HLA-Dr is involved in the HIV-1 binding site on the cells expressing MHC class II antigens. J. Immunol., 141, 1131-1136.
36. McDonald, J.K., Callahan, P.X., Ellis, S. & Smith, R.E. (1971), Polypeptide degradation by dipeptidyl aminopeptidase I (cathepsin C) and related peptidases, in "Tissue proteinases" (A.J. Barrett & J.T. Dingle) (pp. 69-107). North Holland Publishing Co., Amsterdam.
37. McKeating, J.A. & Willey, R.L. (1989), Structure and function of the HIV envelope. AIDS, 3, s35.
38. Mo, H., Markowitz, M., Majer, P., Burt, S.K., Gulnik, S.V., Suvorov, L.I., Erickson, J.W. & Ho, D.D. (1996), Design, synthesis and resistance patterns of MP-134 and MP-167, two novel inhibitors of HIV type 1 protease. AIDS Res. Hum. Retroviruses, 12(1), 55-61.
39. Morimoto, C., Lord, C.I., Zhang, C., Duke-Cohan, J.S., Letvin, N.L. & Schlossman, S.F. (1994), Role of CD26/dipeptidyl peptidase IV in human immunodeficiency virus type 1 infection and apoptosis. Proc. Natl. Acad. Sci. USA, 91, 9960-9964.
40. Nonaka, G.-I., Nishioka, I., Nishizawa, M., Yamagishi, T., Kashiwada, Y., Dutschman, G.E., Bodner, A.J., Kilkuskie, R.E., Cheng, Y.-C. & Lee, K.-H. (1990), Anti-AIDS agents. - 2. Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte cells. J. Nat. Prod., 53(3), 587-595.
41. Noso, N., Sticherling, M., Bartels, J., Mallet, A.I., Christopher, E. & Schroder, J.M. (1996), Identification of an N-terminally truncated form of the chemokine RANTES and granulocyte-macrophage colony-stimulating factor as major eosinophil attractants released by cytokine-stimulated dermal fibroblasts. J. Immunol., 156, 1946-1953.
42. Oravecz, T., Roderiquez, G., Koffi, J., Wang, J., Ditto, M., Bou-Habib, D.C., Lusso, P. & Norcross, M.A. (1995), CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV-1 strains in a T-cell line. Nat. Med., 1(9), 919-926.
43. Oravecz, T., Pall, M. & Norcross, M.A. (1996), β-Chemokine inhibition of monocytotropic HIV-1 infection. J. Immunol., 157, 1329-1332.
44. Patience, C., McKnight, A., Clapham, P.R., Boyd, M.T., Weiss, R.A. & Schulz, T.F. (1994), CD26 antigen and HIV fusion? Science, 264, 1159-1160.
45. Roderriquez, G., Oravecz, T., Yanagishita, M., Bou-Habib, C.D., Mostowski, H. & Norcross, M.A. (1995), Mediation of human immunodeficiency virus type 1 binding by interaction of cell surface heparan sulfate proteoglycans with the V3 region of envelope gp120-gp41. J. Virol., 69, 2233-2239.
46. Schon, E., Demuth, H.-U., Eichman, E., Horst, H.-J., Korner, I.-J., Kopp, J., Mattern, T., Neubert, K., Noll, F., Ulmer, A.J., Barth, A. & Ansorge, S. (1989), Dipeptidyl peptidase IV in human T lymphocytes. Impaired induction of interleukin-2 and gamma interferon due to specific inhibition of dipeptidyl peptidase IV. Scand. J. Immunol., 29, 127-132.
47. Schon, E., Born, H., Demuth, H.-U., Faust, J., Neubert, K., Steinmetzer, T., Barth, A. & Ansorge, S. (1991), Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on the activity of dipeptidyl peptidase IV and proliferation of human lymphocytes. Biol. Chem. Hoppe-Seyler, 372, 305-311.
48. Schroder, J.M., Sticherling, M., Henneicke, H.H. & Preissner, W.C. (1990), IL-1a or tumor necrosis factor-a stimulate release of three NAP-1/IL-8-related neutrophil chemotactic proteins in human dermal fibroblasts. J. Immunol., 144, 2223-2232.
49. Seddiki, N., Ramdani, A., Saffar, L., Portoukalian, J., Gluckman, J.-C. & Gattegno, L. (1994), A monoclonal antibody directed to sulfatide inhibits the binding of human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein to macrophages but not their infection by the virus. Biochem. Biophys. Acta, 1225, 289-296.
50. Stamatatos, L. & Levy, J.A. (1994), CD26 is not involved in infection of peripheral blood mononuclear cells by HIV-1. AIDS, 8, 1727-1728.
51. Steeg, C., Hartwig, U. & Fleischer, B. (1995), Unchanged signalling capacity of mutant CD26/dipeptidylpeptidase IV molecules devoid of enzymatic activity. Cell. Immunol., 164, 311-315.
52. Tanaka, T., Camerini, D., Seed, B., Torimoto, Y., Dang, N.H., Kameoka, J., Dahlberg, H.N., Schlossman, S.F. & Morimoto, C. (1992), Cloning and functional expression of the T-cell activation antigen CD26. J. Immunol., 149, 481-486.
53. Tanaka, T., Kameoka, J., Yaron, A., Schlossman, S.F. & Morimoto, C. (1993), The costimulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzymatic activity. Proc. Natl. Acad. Sci. USA, 90, 4586-4590.
54. Valle-Blazquez, M., Madueno, J.A., Gonzalez, R., Jurado, R., Bachovchin, W.W., Pena, J. & Munoz, E. (1992), Selective decrease of CD26 expression in T cells from HIV-infected individuals. J. Immunol., 149, 3073-3077.
55. -, cells by a cyclopeptide inhibitor of the DPP IV activity of CD26, in "Peptides 1996" (Ramage, R. & Epton, R.). Mayflower Worldwide, 1997.
56. Werner, A., Mattern, T., Ulmer, A.J., Flad, H.D., Kurth, R. & Baier, M. (1994), CD26 is not required for infection of the lymphoma cell line C8166 with HIV-1. AIDS, 8, 1348-1349.
57. West, W.H.L. & Stott, E.J. (1994), Cell surface expression of CD26 does not correlate with susceptibility to immunodeficiency viruses. AIDS, 8, 1349-1350.