메뉴 건너뛰기




Volumn 423, Issue 1-2, 1999, Pages 125-136

Tk(+/-) mouse model for detecting in vivo mutation in an endogenous, autosomal gene

Author keywords

5 bromo 2' deoxyuridine; Knockout; Mutation; N ethyl N nitrosourea; Thymidine kinase

Indexed keywords

BROXURIDINE; ETHYLNITROSOUREA; THYMIDINE KINASE; TIOGUANINE; TRIFLURIDINE;

EID: 0033601826     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00234-6     Document Type: Article
Times cited : (41)

References (54)
  • 2
    • 0025765309 scopus 로고
    • Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide
    • Aidoo A., Lyn-Cook L.E., Mittelstaedt R.A., Heflich R.H., Casciano D.A. Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide. Environ. Mol. Mutagen. 17:1991;141-151.
    • (1991) Environ. Mol. Mutagen. , vol.17 , pp. 141-151
    • Aidoo, A.1    Lyn-Cook, L.E.2    Mittelstaedt, R.A.3    Heflich, R.H.4    Casciano, D.A.5
  • 3
    • 0021857850 scopus 로고
    • A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes
    • Jones I.M., Burkhart-Schultz K., Carrano A.V. A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes. Mutat. Res. 147:1985;97-105.
    • (1985) Mutat. Res. , vol.147 , pp. 97-105
    • Jones, I.M.1    Burkhart-Schultz, K.2    Carrano, A.V.3
  • 4
    • 0026076871 scopus 로고
    • Enumeration of 6-thioguanine-resistant T-lymphocytes in the peripheral blood of nonhuman primates (cynomolgus monkeys)
    • Zimmer D.M., Aaron C.S., O'Neill J.P., Albertini R.J. Enumeration of 6-thioguanine-resistant T-lymphocytes in the peripheral blood of nonhuman primates (cynomolgus monkeys). Environ. Mol. Mutagen. 18:1991;161-167.
    • (1991) Environ. Mol. Mutagen. , vol.18 , pp. 161-167
    • Zimmer, D.M.1    Aaron, C.S.2    O'Neill, J.P.3    Albertini, R.J.4
  • 5
    • 0022309612 scopus 로고
    • HPRT: Gene structure, expression, and mutation
    • Stout J.T., Caskey C.T. HPRT: gene structure, expression, and mutation. Annu. Rev. Genet. 19:1985;127-148.
    • (1985) Annu. Rev. Genet. , vol.19 , pp. 127-148
    • Stout, J.T.1    Caskey, C.T.2
  • 6
    • 0024495465 scopus 로고
    • Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: A perspective
    • DeMarini D.M., Brockman H.E., de Serres F.J., Evans H.H., Stankowski L.F.J., Hsie A.W. Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: a perspective. Mutat. Res. 220:1989;11-29.
    • (1989) Mutat. Res. , vol.220 , pp. 11-29
    • DeMarini, D.M.1    Brockman, H.E.2    De Serres, F.J.3    Evans, H.H.4    Stankowski, L.F.J.5    Hsie, A.W.6
  • 8
    • 0026564911 scopus 로고
    • In vitro mammalian mutagenesis as a model for genetic lesions in human cancer
    • Hozier J., Applegate M., Moore M.M. In vitro mammalian mutagenesis as a model for genetic lesions in human cancer. Mutat. Res. 270:1992;201-209.
    • (1992) Mutat. Res. , vol.270 , pp. 201-209
    • Hozier, J.1    Applegate, M.2    Moore, M.M.3
  • 9
    • 0022535598 scopus 로고
    • Genotoxicity of γ-irradiation in L5178Y mouse lymphoma cells
    • Moore M.M., Amtower A., Strauss G.H.S., Doerr C. Genotoxicity of γ-irradiation in L5178Y mouse lymphoma cells. Mutat. Res. 174:1986;149-154.
    • (1986) Mutat. Res. , vol.174 , pp. 149-154
    • Moore, M.M.1    Amtower, A.2    Strauss, G.H.S.3    Doerr, C.4
  • 11
    • 0027170192 scopus 로고
    • ENU-induced mutagenesis at a single A:T base pair in transgenic mice containing ΦX174
    • Burkhart J.G., Burkhart B.A., Sampson K.S., Malling H.V. ENU-induced mutagenesis at a single A:T base pair in transgenic mice containing ΦX174. Mutat. Res. 292:1993;69-81.
    • (1993) Mutat. Res. , vol.292 , pp. 69-81
    • Burkhart, J.G.1    Burkhart, B.A.2    Sampson, K.S.3    Malling, H.V.4
  • 15
    • 0032486138 scopus 로고    scopus 로고
    • Comparison of in vivo mutagenesis in the endogenous hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene
    • Manjanatha M.G., Shelton S.D., Aidoo A., Lyn-Cook L.E., Casciano D.A. Comparison of in vivo mutagenesis in the endogenous hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene. Mutat. Res. 401:1998;165-178.
    • (1998) Mutat. Res. , vol.401 , pp. 165-178
    • Manjanatha, M.G.1    Shelton, S.D.2    Aidoo, A.3    Lyn-Cook, L.E.4    Casciano, D.A.5
  • 16
    • 0028991066 scopus 로고
    • Relative sensitivity of the endogenous Hprt gene and lacI transgene in ENU-treated Big Blue™ B6C3F1 mice
    • Skopek T.R., Kort K.L., Marino D.R. Relative sensitivity of the endogenous Hprt gene and lacI transgene in ENU-treated Big Blue™ B6C3F1 mice. Environ. Mol. Mutagen. 26:1995;9-15.
    • (1995) Environ. Mol. Mutagen. , vol.26 , pp. 9-15
    • Skopek, T.R.1    Kort, K.L.2    Marino, D.R.3
  • 17
    • 0029061266 scopus 로고
    • Overview of mutation assays in transgenic mice for routine testing
    • Gorelick N.J. Overview of mutation assays in transgenic mice for routine testing. Environ. Mol. Mutagen. 25:1995;218-230.
    • (1995) Environ. Mol. Mutagen. , vol.25 , pp. 218-230
    • Gorelick, N.J.1
  • 18
    • 0027421332 scopus 로고
    • Comparison of somatic mutation in a transgenic versus host locus
    • Tao K.S., Urlando C., Heddle J.A. Comparison of somatic mutation in a transgenic versus host locus. Proc. Natl. Acad. Sci. U.S.A. 90:1993;10681-10685.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 10681-10685
    • Tao, K.S.1    Urlando, C.2    Heddle, J.A.3
  • 19
    • 0028336644 scopus 로고
    • Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice
    • Winegar R.A., Lutze L.H., Hamer J.D., O'Loughlin K.G., Mirsalis J.C. Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice. Mutat. Res. 307:1994;479-487.
    • (1994) Mutat. Res. , vol.307 , pp. 479-487
    • Winegar, R.A.1    Lutze, L.H.2    Hamer, J.D.3    O'Loughlin, K.G.4    Mirsalis, J.C.5
  • 20
    • 0031428481 scopus 로고    scopus 로고
    • The mutagenic response at the ouabain resistance locus in T cells of mice exposed to N-ethyl-N-nitrosourea parallels the response at the Hprt locus and correlates with mutation target size
    • Dass S.B., Heflich R.H., Casciano D.A. The mutagenic response at the ouabain resistance locus in T cells of mice exposed to N-ethyl-N-nitrosourea parallels the response at the Hprt locus and correlates with mutation target size. Carcinogenesis. 18:1997;2233-2237.
    • (1997) Carcinogenesis , vol.18 , pp. 2233-2237
    • Dass, S.B.1    Heflich, R.H.2    Casciano, D.A.3
  • 21
    • 0023894101 scopus 로고
    • A clonal marker induced by mutation in mouse intestinal epithelium
    • Winton D.J., Blount M.A., Ponder B.A. A clonal marker induced by mutation in mouse intestinal epithelium. Nature. 333:1988;463-466.
    • (1988) Nature , vol.333 , pp. 463-466
    • Winton, D.J.1    Blount, M.A.2    Ponder, B.A.3
  • 22
    • 0018885972 scopus 로고
    • Mutagenicity testing in mammalian cells. I. Derivation of a Chinese hamster ovary cell line heterozygous for the adenine phosphoribosyltransferase and thymidine kinase loci
    • Adair G.M., Carver J.H., Wandres D.L. Mutagenicity testing in mammalian cells. I. Derivation of a Chinese hamster ovary cell line heterozygous for the adenine phosphoribosyltransferase and thymidine kinase loci. Mutat. Res. 72:1980;187-205.
    • (1980) Mutat. Res. , vol.72 , pp. 187-205
    • Adair, G.M.1    Carver, J.H.2    Wandres, D.L.3
  • 23
    • 0019965369 scopus 로고
    • High-frequency nonrandom mutational event at the adenine phosphoribosyltransferase (aprt) locus of sib-selected CHO variants heterozygous for aprt
    • Bradley W.E., Letovanec D. High-frequency nonrandom mutational event at the adenine phosphoribosyltransferase (aprt) locus of sib-selected CHO variants heterozygous for aprt. Somatic Cell Genet. 8:1982;51-66.
    • (1982) Somatic Cell Genet. , vol.8 , pp. 51-66
    • Bradley, W.E.1    Letovanec, D.2
  • 24
    • 0015402142 scopus 로고
    • A mutational assay system using the thymidine kinase locus in mouse lymphoma cells
    • Clive D., Flamm W.G., Machesko M.R., Bernheim N.J. A mutational assay system using the thymidine kinase locus in mouse lymphoma cells. Mutat. Res. 16:1972;77-87.
    • (1972) Mutat. Res. , vol.16 , pp. 77-87
    • Clive, D.1    Flamm, W.G.2    Machesko, M.R.3    Bernheim, N.J.4
  • 25
    • 0018118326 scopus 로고
    • Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay
    • Skopek T.R., Liber H.L., Penman B.W., Thilly W.G. Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay. Biochem. Biophys. Res. Commun. 84:1978;411-416.
    • (1978) Biochem. Biophys. Res. Commun. , vol.84 , pp. 411-416
    • Skopek, T.R.1    Liber, H.L.2    Penman, B.W.3    Thilly, W.G.4
  • 30
    • 0030596059 scopus 로고    scopus 로고
    • Identification of a heteromorphic microsatellite within the thymidine kinase gene in L5178Y mouse lymphoma cells
    • Liechty M.C., Crosby H.J., Murthy A., Davis L.M., Caspary W.J., Hozier J.C. Identification of a heteromorphic microsatellite within the thymidine kinase gene in L5178Y mouse lymphoma cells. Mutat. Res. 371:1996;265-271.
    • (1996) Mutat. Res. , vol.371 , pp. 265-271
    • Liechty, M.C.1    Crosby, H.J.2    Murthy, A.3    Davis, L.M.4    Caspary, W.J.5    Hozier, J.C.6
  • 31
    • 0022197942 scopus 로고
    • Molecular cloning and structural analysis of murine thymidine kinase genomic and cDNA sequences
    • Lin P.F., Lieberman H.B., Yeh D.B., Xu T., Zhao S.Y., Ruddle F.H. Molecular cloning and structural analysis of murine thymidine kinase genomic and cDNA sequences. Mol. Cell Biol. 5:1985;3149-3156.
    • (1985) Mol. Cell Biol. , vol.5 , pp. 3149-3156
    • Lin, P.F.1    Lieberman, H.B.2    Yeh, D.B.3    Xu, T.4    Zhao, S.Y.5    Ruddle, F.H.6
  • 34
    • 0031056113 scopus 로고    scopus 로고
    • Regulation and biological function of thymidine kinase
    • Wintersberger E. Regulation and biological function of thymidine kinase. Biochem. Soc. Trans. 25:1997;303-308.
    • (1997) Biochem. Soc. Trans. , vol.25 , pp. 303-308
    • Wintersberger, E.1
  • 35
    • 0027399166 scopus 로고
    • Adenine phosphoribosyltransferase deficiency with renal deposition of 2,8-dihydroxyadenine leading to nephrolithiasis and chronic renal failure
    • Fye K.H., Sahota A., Hancock D.C., Gelb A.B., Chen J., Sparks J.W., Sibley R.K., Tischfield J.A. Adenine phosphoribosyltransferase deficiency with renal deposition of 2,8-dihydroxyadenine leading to nephrolithiasis and chronic renal failure. Arch. Intern. Med. 153:1993;767-770.
    • (1993) Arch. Intern. Med. , vol.153 , pp. 767-770
    • Fye, K.H.1    Sahota, A.2    Hancock, D.C.3    Gelb, A.B.4    Chen, J.5    Sparks, J.W.6    Sibley, R.K.7    Tischfield, J.A.8
  • 36
    • 0026591855 scopus 로고
    • A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency
    • Sculley D.G., Dawson P.A., Emmerson B.T., Gordon R.B. A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. Hum. Genet. 90:1992;195-207.
    • (1992) Hum. Genet. , vol.90 , pp. 195-207
    • Sculley, D.G.1    Dawson, P.A.2    Emmerson, B.T.3    Gordon, R.B.4
  • 37
    • 0023150598 scopus 로고
    • HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells
    • Hooper M., Hardy K., Handyside A., Hunter S., Monk M. HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature. 326:1987;292-295.
    • (1987) Nature , vol.326 , pp. 292-295
    • Hooper, M.1    Hardy, K.2    Handyside, A.3    Hunter, S.4    Monk, M.5
  • 38
    • 0023090920 scopus 로고
    • A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice
    • Kuehn M.R., Bradley A., Robertson E.J., Evans M.J. A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature. 326:1987;295-298.
    • (1987) Nature , vol.326 , pp. 295-298
    • Kuehn, M.R.1    Bradley, A.2    Robertson, E.J.3    Evans, M.J.4
  • 40
    • 0022504245 scopus 로고
    • Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations
    • Yandell D.W., Dryja T.P., Little J.B. Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations. Somatic Cell Mol. Genet. 12:1986;255-263.
    • (1986) Somatic Cell Mol. Genet. , vol.12 , pp. 255-263
    • Yandell, D.W.1    Dryja, T.P.2    Little, J.B.3
  • 41
    • 0025861765 scopus 로고
    • The genetic toxicology of 5-bromodeoxyuridine in mammalian cells
    • Morris S.M. The genetic toxicology of 5-bromodeoxyuridine in mammalian cells. Mutat. Res. 258:1991;161-188.
    • (1991) Mutat. Res. , vol.258 , pp. 161-188
    • Morris, S.M.1
  • 42
    • 0019954426 scopus 로고
    • +/- mouse lymphoma cells at varying times post-treatment
    • +/- mouse lymphoma cells at varying times post-treatment. Environ. Mutagen. 4:1982;499-519.
    • (1982) Environ. Mutagen. , vol.4 , pp. 499-519
    • Moore, M.M.1    Clive, D.2
  • 45
    • 0023645664 scopus 로고
    • Comparison of the relative mutagenicities of O-alkylthymines site-specifically incorporated into ΦX174 DNA
    • Preston B.D., Singer B., Loeb L.A. Comparison of the relative mutagenicities of O-alkylthymines site-specifically incorporated into ΦX174 DNA. J. Biol. Chem. 262:1987;13821-13827.
    • (1987) J. Biol. Chem. , vol.262 , pp. 13821-13827
    • Preston, B.D.1    Singer, B.2    Loeb, L.A.3
  • 48
    • 0029821901 scopus 로고    scopus 로고
    • Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice
    • Walker V.E., Gorelick N.J., Andrews J.L., Craft T.R., deBoer J.G., Glickman B.W., Skopek T.R. Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice. Cancer Res. 56:1996;4654-4661.
    • (1996) Cancer Res. , vol.56 , pp. 4654-4661
    • Walker, V.E.1    Gorelick, N.J.2    Andrews, J.L.3    Craft, T.R.4    DeBoer, J.G.5    Glickman, B.W.6    Skopek, T.R.7
  • 49
    • 0023753558 scopus 로고
    • Influence of neighboring base sequence on the distribution and repair of N-ethyl-N-nitrosourea-induced lesions in Escherichia coli
    • Burns P.A., Gordon A.J., Kunsmann K., Glickman B.W. Influence of neighboring base sequence on the distribution and repair of N-ethyl-N-nitrosourea-induced lesions in Escherichia coli. Cancer Res. 48:1988;4455-4458.
    • (1988) Cancer Res. , vol.48 , pp. 4455-4458
    • Burns, P.A.1    Gordon, A.J.2    Kunsmann, K.3    Glickman, B.W.4
  • 50
    • 0039333555 scopus 로고
    • DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea
    • Richardson K.K., Richardson F.C., Crosby R.M., Swenberg J.A., Skopek T.R. DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea. Proc. Natl. Acad. Sci. U.S.A. 84:1987;344-348.
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 344-348
    • Richardson, K.K.1    Richardson, F.C.2    Crosby, R.M.3    Swenberg, J.A.4    Skopek, T.R.5
  • 52
    • 0028157494 scopus 로고
    • International Commission for Protection Against Environmental Mutagens and Carcinogens. Working paper no. 3. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo
    • Cole J., Skopek T.R. International Commission for Protection Against Environmental Mutagens and Carcinogens. Working paper no. 3. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo. Mutat. Res. 304:1994;33-105.
    • (1994) Mutat. Res. , vol.304 , pp. 33-105
    • Cole, J.1    Skopek, T.R.2
  • 53
    • 0032541153 scopus 로고    scopus 로고
    • Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
    • Chen T., Aidoo A., Manjanatha M.G., Mittelstaedt R.A., Shelton S.D., Lyn-Cook L.E., Casciano D.A., Heflich R.H. Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats. Mutat. Res. 403:1998;199-214.
    • (1998) Mutat. Res. , vol.403 , pp. 199-214
    • Chen, T.1    Aidoo, A.2    Manjanatha, M.G.3    Mittelstaedt, R.A.4    Shelton, S.D.5    Lyn-Cook, L.E.6    Casciano, D.A.7    Heflich, R.H.8
  • 54
    • 0029095542 scopus 로고
    • The use of L5178Y mouse lymphoma cells to assess the mutagenic, clastogenic and aneugenic properties of chemicals
    • Combes R.D., Stopper H., Caspary W.J. The use of L5178Y mouse lymphoma cells to assess the mutagenic, clastogenic and aneugenic properties of chemicals. Mutagenesis. 10:1995;403-408.
    • (1995) Mutagenesis , vol.10 , pp. 403-408
    • Combes, R.D.1    Stopper, H.2    Caspary, W.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.