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Volumn 377, Issue 1, 1997, Pages 27-36

Isolation of an APRT heterozygote from TK6 human lymphoblasts: Predominance of multi-locus loss of heterozigosity among spontaneous APRT- mutants

Author keywords

APRT; Chromosomal context in mutagenesis; Loss of heterozygosity

Indexed keywords

ARTICLE; CHROMOSOME 16Q; CHROMOSOME 17Q; DAUDI CELL; DNA SEQUENCE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; MUTAGENESIS; MUTANT; MUTATION RATE; PRIORITY JOURNAL;

EID: 0031004658     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00055-9     Document Type: Article
Times cited : (14)

References (63)
  • 1
    • 0022254220 scopus 로고
    • The molecular nature of mutations in cultured mammalian cells: A review
    • Thacker, J. (1985) The molecular nature of mutations in cultured mammalian cells: a review, Mutation Res., 150, 431-442.
    • (1985) Mutation Res. , vol.150 , pp. 431-442
    • Thacker, J.1
  • 2
    • 0027176421 scopus 로고
    • In vivo mutation at the human HPRT locus
    • Cariello, N.F. and T.R. Skopek (1993) In vivo mutation at the human HPRT locus, Trends Genet., 9, 322-326.
    • (1993) Trends Genet. , vol.9 , pp. 322-326
    • Cariello, N.F.1    Skopek, T.R.2
  • 3
    • 0028916130 scopus 로고
    • Mapping the end points of large deletions affecting the hprt locus in human peripheral blood cells and cell lines
    • Nelson, S.L., I.M. Jones, J.C. Fuscoe, K. Burkhart-Schultz and A.J. Grosovsky (1995) Mapping the end points of large deletions affecting the hprt locus in human peripheral blood cells and cell lines, Radiat. Res., 141, 2-10.
    • (1995) Radiat. Res. , vol.141 , pp. 2-10
    • Nelson, S.L.1    Jones, I.M.2    Fuscoe, J.C.3    Burkhart-Schultz, K.4    Grosovsky, A.J.5
  • 4
    • 0021965121 scopus 로고
    • Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes
    • Albertini, R.J., J.P. O'Neill, J.A. Nicklas, N.H. Heintz and P.C. Kelleher (1985) Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes, Nature, 316, 369-371.
    • (1985) Nature , vol.316 , pp. 369-371
    • Albertini, R.J.1    O'Neill, J.P.2    Nicklas, J.A.3    Heintz, N.H.4    Kelleher, P.C.5
  • 6
    • 0027312083 scopus 로고
    • Analysis of large deletions in the HPRT gene of primary human fibroblasts using the polymerase chain reaction
    • Morris, T., W. Masson, B. Singleton and J. Thacker (1993) Analysis of large deletions in the HPRT gene of primary human fibroblasts using the polymerase chain reaction, Somat. Cell Mol. Genet., 19, 9-19.
    • (1993) Somat. Cell Mol. Genet. , vol.19 , pp. 9-19
    • Morris, T.1    Masson, W.2    Singleton, B.3    Thacker, J.4
  • 8
    • 0026508260 scopus 로고
    • Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro
    • Li, C.Y., D.W. Yandell and J.B. Little (1992) Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro, Somat. Cell Mol. Genet., 18, 77-87.
    • (1992) Somat. Cell Mol. Genet. , vol.18 , pp. 77-87
    • Li, C.Y.1    Yandell, D.W.2    Little, J.B.3
  • 9
    • 0029125078 scopus 로고
    • Recombinagenic activity of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human lymphoblastoid cells
    • Honma, M. and J.B. Little (1995) Recombinagenic activity of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human lymphoblastoid cells, Carcinogenesis, 16, 1717-1722.
    • (1995) Carcinogenesis , vol.16 , pp. 1717-1722
    • Honma, M.1    Little, J.B.2
  • 10
    • 0025125796 scopus 로고
    • Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells
    • Yandell, D.W., T.P. Dryja and J.B. Little (1990) Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells, Mutat. Res., 229, 89-102.
    • (1990) Mutat. Res. , vol.229 , pp. 89-102
    • Yandell, D.W.1    Dryja, T.P.2    Little, J.B.3
  • 11
    • 0026561595 scopus 로고
    • A comparison of induced mutation at homologous alleles of the tk locus in human cells. II. Molecular analysis of mutants
    • Amundson, S.A. and H.L. Liber (1992) A comparison of induced mutation at homologous alleles of the tk locus in human cells. II. Molecular analysis of mutants, Mutat. Res., 267, 89-95.
    • (1992) Mutat. Res. , vol.267 , pp. 89-95
    • Amundson, S.A.1    Liber, H.L.2
  • 13
    • 0026475266 scopus 로고
    • Hereditary conditions in which the loss of heterozygosity may be important
    • Muller, H. and R. Scott (1992) Hereditary conditions in which the loss of heterozygosity may be important, Mutat. Res., 284, 15-24.
    • (1992) Mutat. Res. , vol.284 , pp. 15-24
    • Muller, H.1    Scott, R.2
  • 16
    • 0024314009 scopus 로고
    • Molecular basis of spontaneous mutation at the aprt locus of hamster cells
    • Phear, G., W. Armstrong and M. Meuth (1989) Molecular basis of spontaneous mutation at the aprt locus of hamster cells, J. Mol. Biol., 209, 577-582.
    • (1989) J. Mol. Biol. , vol.209 , pp. 577-582
    • Phear, G.1    Armstrong, W.2    Meuth, M.3
  • 17
    • 0023672576 scopus 로고
    • Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells
    • Grosovsky, A.J., J.G. de Boer, P.J. de Jong, E.A. Drobetsky and B.W. Glickman (1988) Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells, Proc. Natl. Acad. Sci. USA, 85, 185-188.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 185-188
    • Grosovsky, A.J.1    De Boer, J.G.2    De Jong, P.J.3    Drobetsky, E.A.4    Glickman, B.W.5
  • 18
    • 0021088838 scopus 로고
    • Mechanism of mutation at the aprt locus in Chinese hamster ovary cells: Analysis of heterozygotes and hemizygotes
    • Simon, A.E., M.W. Taylor and W.E. Bradley (1983) Mechanism of mutation at the aprt locus in Chinese hamster ovary cells: analysis of heterozygotes and hemizygotes, Mol. Cell. Biol., 3, 1703-1710.
    • (1983) Mol. Cell. Biol. , vol.3 , pp. 1703-1710
    • Simon, A.E.1    Taylor, M.W.2    Bradley, W.E.3
  • 19
    • 0019965369 scopus 로고
    • High-frequency nonrandom mutational event at the adenine phosphoribosyltransferase (aprt) locus of sib-selected CHO variants heterozygous for aprt
    • Bradley, W.E. and D. Letovanec (1982) High-frequency nonrandom mutational event at the adenine phosphoribosyltransferase (aprt) locus of sib-selected CHO variants heterozygous for aprt, Somat. Cell Genet., 8, 51-66.
    • (1982) Somat. Cell Genet. , vol.8 , pp. 51-66
    • Bradley, W.E.1    Letovanec, D.2
  • 20
    • 0342761324 scopus 로고
    • Spectrum of spontaneous mutation at the APRT locus of Chinese hamster ovary cells: An analysis at the DNA sequence level
    • de Jong, P.J., A.J. Grosovsky and B.W. Glickman (1988) Spectrum of spontaneous mutation at the APRT locus of Chinese hamster ovary cells: an analysis at the DNA sequence level, Proc. Natl. Acad. Sci. USA, 85, 3499-3503.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3499-3503
    • De Jong, P.J.1    Grosovsky, A.J.2    Glickman, B.W.3
  • 21
    • 0025035606 scopus 로고
    • Loss of heterozygosity in mammalian cell mutagenesis: Molecular analysis of spontaneous mutations at the aprt locus in CHO cells
    • Ward, M.A., M. Yu, B.W. Glickman and A.J. Grosovsky (1990) Loss of heterozygosity in mammalian cell mutagenesis: molecular analysis of spontaneous mutations at the aprt locus in CHO cells, Carcinogenesis, 11, 1485-1490.
    • (1990) Carcinogenesis , vol.11 , pp. 1485-1490
    • Ward, M.A.1    Yu, M.2    Glickman, B.W.3    Grosovsky, A.J.4
  • 22
    • 0026546799 scopus 로고
    • Mutations recovered in the Chinese hamster aprt gene after exposure to carboplatin: A comparison with cisplatin
    • de Boer, J.G. and B.W. Glickman (1992) Mutations recovered in the Chinese hamster aprt gene after exposure to carboplatin: a comparison with cisplatin, Carcinogenesis, 13, 15-17.
    • (1992) Carcinogenesis , vol.13 , pp. 15-17
    • De Boer, J.G.1    Glickman, B.W.2
  • 23
    • 0020085617 scopus 로고
    • Genetic instability at the adenine phosphoribosyltransferase locus in mouse L cells
    • Tischfield, J.A., J.J. Trill, Y.I. Lee, K. Coy and M.W. Taylor (1982) Genetic instability at the adenine phosphoribosyltransferase locus in mouse L cells, Mol. Cell. Biol., 2, 250-257.
    • (1982) Mol. Cell. Biol. , vol.2 , pp. 250-257
    • Tischfield, J.A.1    Trill, J.J.2    Lee, Y.I.3    Coy, K.4    Taylor, M.W.5
  • 24
    • 0025753246 scopus 로고
    • Multiple dispersed spontaneous mutations: A novel pathway of mutation in a malignant human cell line
    • Harwood, J., A. Tachibana and M. Meuth (1991) Multiple dispersed spontaneous mutations: a novel pathway of mutation in a malignant human cell line, Mol. Cell. Biol., 11, 3163-3170.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3163-3170
    • Harwood, J.1    Tachibana, A.2    Meuth, M.3
  • 25
    • 0025741791 scopus 로고
    • Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells
    • Klinedinst, D.K. and N.R. Drinkwater (1991) Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells, Mutat. Res., 250, 365-374.
    • (1991) Mutat. Res. , vol.250 , pp. 365-374
    • Klinedinst, D.K.1    Drinkwater, N.R.2
  • 26
    • 0026731418 scopus 로고
    • Allelic losses in mutations at the aprt locus of human lymphoblastoid cells
    • Fujimori, A., A. Tachibana and K. Tatsumi (1992) Allelic losses in mutations at the aprt locus of human lymphoblastoid cells, Mutat. Res., 269, 55-62.
    • (1992) Mutat. Res. , vol.269 , pp. 55-62
    • Fujimori, A.1    Tachibana, A.2    Tatsumi, K.3
  • 33
    • 0028123514 scopus 로고
    • Allele loss on chromosome 16q24.2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread
    • Tsuda, H., D.F. Callen, T. Fukutomi, Y. Nakamura and S. Hirohashi (1994) Allele loss on chromosome 16q24.2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread, Cancer Res., 54, 513-517.
    • (1994) Cancer Res. , vol.54 , pp. 513-517
    • Tsuda, H.1    Callen, D.F.2    Fukutomi, T.3    Nakamura, Y.4    Hirohashi, S.5
  • 35
    • 0028959056 scopus 로고
    • Mapping of regions of physical deletion on chromosome 16q in prostate cancer cells by fluorescence in situ hybridization (FISH)
    • Cher, M.L., T. Ito, N. Weidner, P.R. Carroll and R.H. Jensen (1995) Mapping of regions of physical deletion on chromosome 16q in prostate cancer cells by fluorescence in situ hybridization (FISH), J. Urol., 153, 249-254.
    • (1995) J. Urol. , vol.153 , pp. 249-254
    • Cher, M.L.1    Ito, T.2    Weidner, N.3    Carroll, P.R.4    Jensen, R.H.5
  • 39
    • 0027525473 scopus 로고
    • Evidence for high-frequency allele loss at the aprt locus in TK6 human lymphoblasts
    • Smith, L.E. and A.J. Grosovsky (1993) Evidence for high-frequency allele loss at the aprt locus in TK6 human lymphoblasts, Mutat. Res., 289, 245-254.
    • (1993) Mutat. Res. , vol.289 , pp. 245-254
    • Smith, L.E.1    Grosovsky, A.J.2
  • 40
    • 0027819028 scopus 로고
    • Genetic instability on chromosome 16 in a human B lymphoblastoid cell line
    • Smith, L.E. and A.J. Grosovsky (1993) Genetic instability on chromosome 16 in a human B lymphoblastoid cell line, Somat. Cell Mol. Genet., 19, 515-527.
    • (1993) Somat. Cell Mol. Genet. , vol.19 , pp. 515-527
    • Smith, L.E.1    Grosovsky, A.J.2
  • 42
    • 0016197296 scopus 로고
    • Mutants of cultured chinese hamster cells deficient in adenine phosphoribosyl transferase
    • Jones, G.E. and P.A. Sargent (1974) Mutants of cultured chinese hamster cells deficient in adenine phosphoribosyl transferase, Cell, 2, 43-54.
    • (1974) Cell , vol.2 , pp. 43-54
    • Jones, G.E.1    Sargent, P.A.2
  • 43
    • 0019965768 scopus 로고
    • Mutation assay at the thymidine kinase locus in diploid human lymphoblasts
    • Liber, H.L. and W.G. Thilly (1982) Mutation assay at the thymidine kinase locus in diploid human lymphoblasts, Mutat. Res., 94, 467-485.
    • (1982) Mutat. Res. , vol.94 , pp. 467-485
    • Liber, H.L.1    Thilly, W.G.2
  • 44
    • 0018118326 scopus 로고
    • Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay
    • Skopek, T.R., H.L. Liber, B.W. Penman and W.G. Thilly (1978) Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay, Biochem. Biophys. Res. Commun., 84, 411-416.
    • (1978) Biochem. Biophys. Res. Commun. , vol.84 , pp. 411-416
    • Skopek, T.R.1    Liber, H.L.2    Penman, B.W.3    Thilly, W.G.4
  • 45
    • 0028323180 scopus 로고
    • Spectrum of X-ray-induced mutations in the human hprt gene
    • Nelson, S.L., C.R. Giver and A.J. Grosovsky (1994) Spectrum of X-ray-induced mutations in the human hprt gene, Carcinogenesis, 15, 495-502.
    • (1994) Carcinogenesis , vol.15 , pp. 495-502
    • Nelson, S.L.1    Giver, C.R.2    Grosovsky, A.J.3
  • 46
    • 0023194576 scopus 로고
    • Comparative anatomy of the human APRT gene and enzyme: Nucleotide sequence divergence and conservation of a nonrandom CpG dinucleotide arrangement
    • Broderick, T.P., D.A. Schaff, A.M. Bertino, M.K. Dush, J.A. Tischfield and P.J. Stambrook (1987) Comparative anatomy of the human APRT gene and enzyme: nucleotide sequence divergence and conservation of a nonrandom CpG dinucleotide arrangement, Proc. Natl. Acad. Sci. USA, 84, 3349-3353.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 3349-3353
    • Broderick, T.P.1    Schaff, D.A.2    Bertino, A.M.3    Dush, M.K.4    Tischfield, J.A.5    Stambrook, P.J.6
  • 48
    • 0001641514 scopus 로고
    • Mutations of bacteria from virus sensitivity to virus resistance
    • Luria, S.E. and M. Delbruck (1943) Mutations of bacteria from virus sensitivity to virus resistance, Genetics, 28, 491-511.
    • (1943) Genetics , vol.28 , pp. 491-511
    • Luria, S.E.1    Delbruck, M.2
  • 49
    • 0021966745 scopus 로고
    • A deterministic approach for the estimation of mutation rates in cultured mammalian cells
    • Li, I.C., S.C. Wu, J. Fu and E.H. Chu (1985) A deterministic approach for the estimation of mutation rates in cultured mammalian cells, Mutat. Res., 149, 127-132.
    • (1985) Mutat. Res. , vol.149 , pp. 127-132
    • Li, I.C.1    Wu, S.C.2    Fu, J.3    Chu, E.H.4
  • 51
    • 0026652095 scopus 로고
    • Isolation and characterisation of (AC)n microsatellite genetic markers from human chromosome 16
    • Thompson, A.D., Y. Shen, K. Holman, G.R. Sutherland, D.F. Callen and R.I. Richards (1992) Isolation and characterisation of (AC)n microsatellite genetic markers from human chromosome 16, Genomics, 13, 402-408.
    • (1992) Genomics , vol.13 , pp. 402-408
    • Thompson, A.D.1    Shen, Y.2    Holman, K.3    Sutherland, G.R.4    Callen, D.F.5    Richards, R.I.6
  • 52
    • 0027381294 scopus 로고
    • DNA-sequence specificity of mutations at the human thymidine kinase locus
    • Grosovsky, A.J., B.N. Walter and C.R. Giver (1993) DNA-sequence specificity of mutations at the human thymidine kinase locus, Mutat. Res., 289, 231-243.
    • (1993) Mutat. Res. , vol.289 , pp. 231-243
    • Grosovsky, A.J.1    Walter, B.N.2    Giver, C.R.3
  • 54
    • 0030069415 scopus 로고    scopus 로고
    • Characterization of multilocus lesions in human cells exposed to X radiation and radon
    • Chaudhry, M.A., Q. Jiang, M. Ricanati, M.F. Horng and H.H. Evans (1996) Characterization of multilocus lesions in human cells exposed to X radiation and radon, Radiat. Res., 145, 31-38.
    • (1996) Radiat. Res. , vol.145 , pp. 31-38
    • Chaudhry, M.A.1    Jiang, Q.2    Ricanati, M.3    Horng, M.F.4    Evans, H.H.5
  • 55
    • 0020967827 scopus 로고
    • Induction and expression of mutations at multiple drug-resistance marker loci in Chinese hamster ovary cells
    • Adair, G.M. and J.H. Carver (1983) Induction and expression of mutations at multiple drug-resistance marker loci in Chinese hamster ovary cells, Environ. Mutagen., 5, 161-175.
    • (1983) Environ. Mutagen. , vol.5 , pp. 161-175
    • Adair, G.M.1    Carver, J.H.2
  • 56
    • 0027214255 scopus 로고
    • The effects of hypoxia and cysteamine on X-ray mutagenesis in human cells. I. Dose response and Southern blot analysis of induced mutants
    • Denault, C.M. and H.L. Liber (1993) The effects of hypoxia and cysteamine on X-ray mutagenesis in human cells. I. Dose response and Southern blot analysis of induced mutants, Radiat. Res., 135, 98-107.
    • (1993) Radiat. Res. , vol.135 , pp. 98-107
    • Denault, C.M.1    Liber, H.L.2
  • 57
    • 0025017063 scopus 로고
    • Molecular characterization of hprt mutants induced by low- And high-LET radiations in human cells
    • Whaley, J.M. and J.B. Little (1990) Molecular characterization of hprt mutants induced by low- and high-LET radiations in human cells, Mutat. Res., 243, 35-45.
    • (1990) Mutat. Res. , vol.243 , pp. 35-45
    • Whaley, J.M.1    Little, J.B.2
  • 59
    • 0022504245 scopus 로고
    • Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations
    • Yandell, D.W., T.P. Dryja and J.B. Little (1986) Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations, Somat. Cell Mol. Genet., 12, 255-263.
    • (1986) Somat. Cell Mol. Genet. , vol.12 , pp. 255-263
    • Yandell, D.W.1    Dryja, T.P.2    Little, J.B.3
  • 60
    • 0028944890 scopus 로고
    • Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines
    • Xia, F., X. Wang, Y.H. Wang, N.M. Tsang, D. Yandell, K.T. Kelsey and H.L. Liber (1995) Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines, Cancer Res., 55, 12-15.
    • (1995) Cancer Res. , vol.55 , pp. 12-15
    • Xia, F.1    Wang, X.2    Wang, Y.H.3    Tsang, N.M.4    Yandell, D.5    Kelsey, K.T.6    Liber, H.L.7
  • 61
    • 0028144964 scopus 로고
    • Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation
    • Xia, F., S.A. Amundson, J.A. Nickoloff and H.L. Liber (1994) Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation, Mol. Cell. Biol., 14, 5850-5857.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5850-5857
    • Xia, F.1    Amundson, S.A.2    Nickoloff, J.A.3    Liber, H.L.4
  • 62
    • 0029808933 scopus 로고    scopus 로고
    • Suppression of apoptosis by BCL-2 or BCL-X(L) promotes susceptibility to mutagenesis
    • Chernnobel-Lasserre, C., S. Gauny and A. Kronenberg (1996) Suppression of apoptosis by BCL-2 or BCL-X(L) promotes susceptibility to mutagenesis, Oncogene, 13, 1489-1497.
    • (1996) Oncogene , vol.13 , pp. 1489-1497
    • Chernnobel-Lasserre, C.1    Gauny, S.2    Kronenberg, A.3
  • 63
    • 0028857956 scopus 로고
    • Deletion mapping of highly conserved transcribed sequence downstream from APRT locus
    • Harwood, J. and M. Meuth (1995) Deletion mapping of highly conserved transcribed sequence downstream from APRT locus, Somat. Cell Mol. Genet., 21, 151-160.
    • (1995) Somat. Cell Mol. Genet. , vol.21 , pp. 151-160
    • Harwood, J.1    Meuth, M.2


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