Actions of adenosine A1 and A2 receptor antagonists on CFTR antibody-inhibited β-adrenergic mucin secretion response

British Journal of Pharmacology

Volumn 125, Issue 4, 1998, Pages 697-704

  Pereira, M M C ^a   Mills, C Lloyd ^a,b   Dormer, R L ^a   McPherson, M A ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Adenosine receptor antagonists; CFTR; Mucin secretion; Submandibular glands

Indexed keywords

8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE RECEPTOR; ANTIBODY; BETA ADRENERGIC RECEPTOR; CHLORIDE CHANNEL; CYCLIC AMP; DIMETHYLPROPARGYLXANTHINE; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; MUCIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; 3,7 DIMETHYL 1 PROPARGYLXANTHINE; 3,7-DIMETHYL-1-PROPARGYLXANTHINE; 8-CYCLOPENTYL-1,3-DIMETHYLXANTHINE; DRUG DERIVATIVE; THEOBROMINE; THEOPHYLLINE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYSTIC FIBROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SECRETION; SUBMANDIBULAR GLAND; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTROPHORESIS; GEL CHROMATOGRAPHY; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SERODIAGNOSIS;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; ANTIBODIES; CHROMATOGRAPHY, GEL; CYCLIC AMP; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, CELLULOSE ACETATE; MUCINS; PHOSPHORYLATION; PRECIPITIN TESTS; RATS; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, PURINERGIC P1; SUBMANDIBULAR GLAND; THEOBROMINE; THEOPHYLLINE;

EID: 0031593399     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702128     Document Type: Article

References (35)

1. BECQ, F., JENSEN, T.J., CHANG, X.-B., SAVOIA, A., ROMMENS, J.M., TSUI, L.-C., BUCHWALD, M., RIORDAN, J.R. & HANRAHAN, J.W. (1994). Phosphatase inhibitors activate normal and defective CFTR chloride channels. Proc. Natl. Acad. Sci. U.S.A., 91, 9160-9164.
2. BRADBURY, N.A., DORMER, R.L. & MCPHERSON, M.A. (1989). Introduction of cyclic AMP phosphodiesterase into rat submandibular acini prevents isoproterenol-stimulaled cyclic AMP rise without affecting mucin secretion. Biochem. Biophys. Res. Commun., 161, 661-671.
3. BRADBURY, N.A., JILLING, T. BERTA, G., SORSCHER, E. J., BRIDGES, R.J. & KIRK, K.L. (1992). Regulation of plasma membrane recycling by CFTR. Science, 256, 530-532.
4. BRADBURY, N.A. & MCPHERSON, M.A. (1988). Isoproterenol-induced desensitization of mucin release in isolated rat submandibular acini. Biochim. Biophys. Acta., 970, 363-370.
5. CHAN, H.-C. KAETZEL, M.A., NELSON, D.J., HAZARIKA, P. & DEDMAN, J.R. (1992). Antibody against a cystic fibrosis transmembrane conductance regulator-derived synthetic peptide inhibits anion currents in human colonic cell line T84. J. Biol. Chem., 267, 8411-8416.
6. CHAPPE, V., METTEY, Y., VIERFOND, J.M., HANRAHAN, J.W., GOLA, M., VERRIER, B., & BECQ, L. (1998). Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel. Brit. J. Pharmacol., 123, 683-693.
7. DORMER, R.L. & MCPHERSON, M.A. (1994). Methylxanthines in the treatment of cystic fibrosis. In Methylxanthines and phosphodiesterase inhibitors in the treatment of airways disease, eds. Costello, J.F. & Piper, P.J. pp. 155-167. Parthenon Publishing, London & New York.
8. DRUMM, M.L., WILKINSON, D.J., SMIT, L.S., WORRELL, R.T., STRONG, T. V., FRIZZELL, R.A., DAWSON, D.C. & COLLINS, F.S. (1991). Chloride conductance expressed by deltaF508 and other mutant CFTRs in Xenopus oocytes. Science, 254, 1797-1799.
9. 1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator deltaF508 mutation. Biochemistry, 34, 9079-9087.
10. HAWS, C.M., NEPOMUCENO, I.B., KROUSE, M.E., WAKELEE, H., LAW, T. XIA, Y., NGUYEN, H. & WINE, J.J. (1996). DeltaF508-CFTR channels: kinetics, activation by forskolin, and potentiation by xanthines. Am. J. Physiol., 270, C1544-C1555.
11. KUVER, R., RAMESH, N., LAU, S., SAVARD, C. LEE, S.P. & OSBORNE, W.R.A. (1994). Constitutive mucin secretion linked to CFTR expression. Biochem. Biophys. Res. Commun., 203, 1457-1462.
12. LANDSELL, K.A., DELANEY, S.J., LUNN, D.P., THOMSON, S.A., SHEPPARD, D.N. & WAINWRIGHT, B.J. (1998). Comparison of the gating behaviour of human and murine cystic fibrosis transmembrane conductance regulator C1 channels expressed in mammalian cells. J. Physiol., 508, 379-392.
13. LAST, K.S., DONKIN, C. & EMBERY, G. (1988). Glycosaminoglycans in human gingival crevicular fluid during orthodontic movement. Arch. Oral Biol., 33, 907-912.
14. LLOYD MILLS, C., DORIN, J.R., DAVIDSON, D.J., PORTEOUS, D.J., ALTON, E.W.F.W., DORMER, R.L. & MCPHERSON, M.A. (1995). Decreased β-adrenergic stimulation of glycoprotein secretion in mice submandibular glands; reversal by the methylxanthine, IBMX. Biochem. Biophys. Res. Commun., 215, 674-681.
15. LLOYD MILLS, C., DORMER, R.L. & MCPHERSON, M.A. (1991). Introduction of BAPTA into intact rat submandibular acini inhibits mucin secretion in response to cholinergic and beta-adrenergic agonists. FEBS Lett., 289, 141-144.
16. LLOYD MILLS, C., PEREIRA, M.M.C., DORMER, R.L. & MCPHERSON, M.A. (1992). An antibody against a CFTR-derived synthetic peptide, incorporated into living submandibular cells, inhibits beta-adrenergic stimulation of mucin secretion. Biochem. Biophys. Res. Commun., 188, 1146-1152.
17. MCPHERSON, M.A. & DORMER, R.L. (1984). Mucin release and calcium fluxes in isolated rat submandibular acini. Biochem. J., 224, 473-481.
18. MCPHERSON, M.A. & DORMER, R.L. (1991). Molecular and cellular biology of cystic fibrosis. Molec. Aspects Med., 12, 1-81.
19. MCPHERSON, M.A. & DORMER, R.L. (1992). Abnormalities in intracellular regulation in cystic fibrosis. British Medical Bulletin, 48, 766-784.
20. MCPHERSON, M.A. & DORMER, R.L. (1994). Cystic fibrosis gene and mucin secretion. Lancet, 343, 7.
21. MCPHERSON, M.A., DORMER, R.L., BRADBURY, N.A., DODGE, J.A. & GOODCHILD, M.C. (1986). Defective β-adrenergic secretory responses in submandibular acinar cells from Cystic Fibrosis patients. Lancet, ii, 1007-1008.
22. 2+. In Cellular and Molecular Basis of Cystic Fibrosis, eds. Mastella, G. & Quinton, P.M. pp. 343-354. San Francisco Press.
23. MCPHERSON, M.A., SHORI, D.K., LLOYD MILLS, C., GOODCHILD, M.C. & DORMER, R.L. (1991). Altered biochemical regulation of secretion in cystic fibrosis epithelial cells. In The identification of the CF (cystic fibrosis) gene: recent progress and new research strategies. Adv. Exptl. Med. Biol. Vol. 290, eds. Tsui, L.-C., Romeo, G., Greger, R. & Gorini, S. pp. 173-186. New York: Plenum Press.
24. MORRIS, R.M., PEREIRA, M.M.C., HALLETT, M.B., MCPHERSON, M.A. & DORMER, R.L. (1998). Cellular localisation of the most common mutant form of the CF gene protein. ΔF508-CFTR. Biochem. Soc. Trans., 26, 293S.
25. PEREIRA, M.M.C., DORMER, R.L. & MCPHERSON, M.A. (1991). Characterisation of anti-peptide CFTR antibodies. Biochem. Soc. Trans., 19, 247S.
26. PEREIRA, M.M.C., DORMER, R.L. & MCPHERSON, M.A. (1995). Mucin secretion mediated by the cystic fibrosis gene protein. Biochem. Soc. Trans., 23, 532S.
27. PEREIRA, M.M.C., DORMER, R.L. & MCPHERSON, M.A. (1998). CPT (8-cyclopentyl theophylline) corrects CFTR antibody inhibited mucin secretion. Biochem. Soc. Trans. 26, S112.
28. QUISSELL, D.O. & BARZEN, K.A. (1980). Secretory responses of dispersed rat submandibular cells. II. Mucin secretion. Am. J. Physiol., 238, C99-C106.
29. QUISSELL, D.O., BARZEN, K.A. & LAFFERTY, J.L. (1981). Role of calcium and cAMP in the regulation of rat submandibular mucin secretion. Am. J. Physiol., 241, C76-C85.
30. RIORDAN, J.R. (1993). The cystic fibrosis transmembrane conductance regulator. Ann. Rev. Physiol., 55, 609-630.
31. RIORDAN, J.R., ROMMENS, J.M., KEREM, B.-S., ALON, N., ROZMAHEL, R., GRZELCZAK, Z., ZIELENSKI, J., LOK, S., PLAVSIC, N., CHOU, J.-L., DRUMM, M.L. & IANNUZZI, M.C. (1989). Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA. Science, 245, 1066-1073.
32. SARKADI, B., BAUZON, D., HUCKLE, W.R., EARP, H.S., BERRY, A., SUCHINDRAN, H., PRICE, E.M., OLSEN, J.C., BOUCHER, R.C. & SCARBOROUGH, G.A. (1992). Biochemical characterization of the cystic fibrosis transmembrane conductance regulator in normal and cystic fibrosis epithelial cells. J. Biol. Chem., 267, 2087-2095.
33. SIMSON, J.A.V., SPICER, S.S., SETSER, M.E. & MARTINEZ, J.R. (1978). Histochemistry and ultrastructure of rat submandibular acinar cells. Effects of chronic reserpine on secretion. Lab. Invest., 39, 157-166.
34. THORNTON, D.J., DAVIES, J.R., KRAAYENBRINK, M., RICHARDSON, P.S., SHEEHAN, J.K. & CARLSTEDT, I. (1990). Mucus glycoproteins from 'normal' human tracheobronchial secretion. Biochem. J., 265, 179-186.
35. WADDINGTON, R.J., EMBERY, G. & LAST, K.S. (1988). The glycosaminoglycan content of alveolar and basal bone of the rabbit. Connective Tiss. Res., 17, 171-180.