Synthesis of a tetrasubstituted bicyclo [2.2.2] Octane as a potential inhibitor of influenza virus sialidase

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 4, 1999, Pages 611-614

  Smith, Paul W ^a   Trivedi, Naimisha ^a   Howes, Peter D ^a   Sollis, Steven L ^a   Rahim, George ^a   Bethell, Richard C ^a   Lynn, Sean ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BICYCLO[2.2.2]OCTANE DERIVATIVE; SIALIC ACID; SIALIDASE INHIBITOR; VIRUS SIALIDASE;

ANTIVIRAL ACTIVITY; ARTICLE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; INFLUENZA; INFLUENZA VIRUS A; INFLUENZA VIRUS B;

BICYCLO COMPOUNDS; CARBOXYLIC ACIDS; ENZYME INHIBITORS; INFLUENZA A VIRUS; INFLUENZA B VIRUS; NEURAMINIDASE;

INFLUENZA VIRUS; INFLUENZAVIRUS A; INFLUENZAVIRUS B;

EID: 0033593865     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00033-5     Document Type: Article

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14. 50 value quoted is the concentration of inhibitor required to reduce the enzymic activity in this preparation by 50%.