A cysteine protease inhibitor prevents activation-induced T-cell apoptosis and death of peripheral blood cells from human immunodeficiency virus-infected individuals by inhibiting upregulation of Fas ligand

Blood

Volumn 89, Issue 2, 1997, Pages 550-557

  Yang, Yili ^b   Liu, Zhi Hong ^b   Ware, Carl F ^b   Ashwell, Jonathan D ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALOXISTATIN; CYSTEINE PROTEINASE INHIBITOR; DNA FRAGMENT; FAS ANTIGEN; LIGAND; MESSENGER RNA;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYBRIDOMA; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0031024011     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.2.550     Document Type: Article

References (59)

1. Cohen JJ, Duke RC, Fadok VA, Sellins KS: Apoptosis and programmed cell death in immunity. Annu Rev Immunol 10:267, 1992
2. Kappler JW, Roehm N, Marrack P: T cell tolerance by clonal elimination in the thymus. Cell 49:273, 1987
3. Green DR, Scott DW: Activation-induced apoptosis in lymphocytes. Curr Opin Immunol 6:476, 1994
4. Alderson MR, Tough TW, Davis-Smith T, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F, Lynch DH: Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exp Med 181:71, 1995
5. Dhein J, Walczak H, Bäumler C, Debatin K-M, Krammer PH: Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373:438, 1995
6. Brunner T, Modil RJ, LaFace D, Yoo NJ, Mahboubi A, Echeverri F, Martin SJ, Force WR, Lynch DH, Ware CF, Green DR: Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373:441, 1995
7. Ju S-T, Panka DJ, Cui H, Ettinger R, El-Khatib M, Sherr DH, Stanger BZ, Marchak-Rothstein A: Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444, 1995
8. Yang Y, Mercep M, Ware CF, Ashwell JD: Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: Inhibition of Fas ligand expression by retinoic acid and glucocorticoids. J Exp Med 181:1673, 1995
9. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S: Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314, 1992
10. Russell JH, Rush B, Weaver C, Wang R: Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc Natl Acad Sci USA 90:4409, 1993
11. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S: Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969, 1994
12. Rieux-Laucat F, Le Deist F, Hivroz C, Roberts IAG, Debatin KM, Fischer A, de Villartay JP: Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 268:1347, 1995
13. Fisher GH, Rosenberg FJ, Straus SE, Dale JK, Middelton LA, Lin AY, Strober W, Lenardo MJ, Puck JM: Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81:935, 1995
14. Fauci AS: The human immunodeficiency virus: Infectivity and mechanisms of pathogenesis. Science 239:617, 1988
15. Schnittman SM, Fauci AS: Human immunodeficiency virus and acquired immunodeficiency syndrome: An update. Adv Intern Med 39:305, 1994
16. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 175:331, 1992
17. Meyaard L, Otto SA, Jonker RR, Mijinster MJ, Keet RPM, Miedema F: Programmed death of T cells in HIV-1 infection. Science 257:217, 1992
18. Geougeon M-L, Montagnier L: Apoptosis in AIDS. Science 260:1269, 1993
19. Gougeon M-L, Garcia S, Heeney J, Tschopp R, Lecoeur H, Guetard D, Rame V, Dauguet C, Montagnier L: Programmed cell death in AIDS-related HIV and SIV infection. AIDS Res Hum Retroviruses 9:553, 1993
20. Estaquier J, Idziorek T, De Bels F, Barré-Sinoussi F, Hurtrel B, Aubertin A-M, Venet A, Mehtali M, Muchmore E, Michel P, Mouton Y, Girard M, Ameisen JC: Programmed cell death and AIDS: Significance of T-cell apoptosis in pathogenic and nonpathogenic primate lentiviral infections. Proc Natl Acad Sci USA 91:9431, 1994
21. Finkel TH, Tudor-Williams G, Banda NK, Cotton MF, Curiel T, Monks C, Baba TW, Ruprecht RM, Kupfer A: Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV-and SIV-infected lymph nodes. Nat Med 1:129, 1995
22. Muro-Cacho CA, Pantaleo G, Fauci AS: Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J Immunol 154:5555, 1995
23. Ameisen JC: Programmed cell death and AIDS: From hypothesis to experiment. Immunol Today 13:388, 1992
24. Sarin A, Adams DH, Henkart PA: Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells. J Exp Med 178:1693, 1993
25. + donors by cysteine protease inhibitors. J Immunol 153:862, 1994
26. Debatin KM, Fahrig-Faissner A, Enenkel-Stoodt S, Kreuz W, Benner A, Krammer PH: High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children. Blood 83:3101, 1994 (letter)
27. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA: Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 181:2029, 1995
28. Crowe PD, VanArsdale TL, Walter BN, Dahms KM, Ware CF: Production of lymphotoxin (LTα) and a soluble dimeric form of its receptor using the baculovirus expression system. J Immunol Methods 168:79, 1994
29. Ashwell JD, Cunningham RE, Noguchi PD, Hernandez D: Cell growth cycle block of T cell hybridomas upon activation with antigen. J Exp Med 165:173, 1987
30. 2+-independent T cell-mediated cytotoxicity. J Exp Med 177:195, 1993
31. Yang C-W, Vlassara H, Peten EP, He C-J, Striker GE, Striker LJ: Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease. Proc Natl Acad Sci USA 91:9436, 1994
32. Yang Y, Vacchio MS, Ashwell JD: 9-Cis retinoic acid inhibits activation-driven T cell apoptosis: Implications for retinoid X receptor involvement in thymocyte development. Proc Natl Acad Sci USA 90:6170, 1993
33. Mercep M, Bluestone JA, Noguchi PD, Ashwell JD: Inhibition of transformed T cell growth in vitro by monoclonal antibodies directed against distinct activating molecules. J Immunol 140:324, 1988
34. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
35. Yang Y, Bailey J, Vacchio MS, Yarchoan R, Ashwell JD: Retinoic acid inhibition of ex vivo HIV-associated apoptosis of peripheral blood cells. Proc Natl Acad Sci USA 92:3051, 1995
36. Sarin A, Nakajima H, Henkart PA: A protease-dependent TCR-induced death pathway in mature lymphocytes. J Immunol 154:5806, 1995
37. Fauci AS: Multifactorial nature of human immunodeficiency virus disease: Implications for therapy. Science 262:1011, 1993
38. 2-chain type IV collagen mRNAs in adult mouse glomeruli: Competitive PCR. Am J Physiol 263:F951, 1992
39. Henkart PA: Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules. Immunity 1:343, 1994
40. Heusel JW, Wesselschmidt RL, Shresta S, Russell JH, Ley TJ: Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76:977, 1994
41. Ellis HM, Horvitz HR: Genetic control of programmed cell death in the nematode C. elegans. Cell 44:817, 1986
42. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR: The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 β-converting enzyme. Cell 75:641, 1993
43. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Roadman L, Salfeld J, Towne E, Tracey D, Wardwell S, Wei F-Y, Wong W, Kamon R, Seshadri T: Mice-deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell 80:401, 1995
44. Martin SJ, Green DR: Protease activation during apoptosis: Death by a thousand cuts? Cell 82:349, 1995
45. Enari M, Hug H, Nagata S: Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375:78, 1995
46. Los M, Van de Craen M, Penning LC, Schenk H, Westendorp M, Baeuerle PA, Droge W, Krammer PH, Fiers W, Schulze-Osthoff K: Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature 375:81, 1995
47. Zhu H, Fearnhead HO, Cohen GM: An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells. FEBS Lett 374:303, 1995
48. Wright SC, Wei QS, Zhong J, Zheng H, Kinder DH, Larrick JW: Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation. J Exp Med 180:2113, 1994
49. McGowan EB, Becker E, Detwiler TC: Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d. Biochem Biophys Res Commun 158:432, 1989
50. Saido TC, Sorimachi H, Suzuki K: Calpain: New perspectives in molecular diversity and physiological-pathological involvement. FASEB J 8:814, 1994
51. Deshpande RV, Goust J-M, Chakraboarti AK, Barbosa E, Hogan EL, Banik NL: Calpain expression in lymphoid cells: Increased mRNA and protein levels after cell activation. J Biol Chem 270:2497, 1995
52. Li CJ, Friedman DJ, Wang C, Metelev V, Pardee AB: Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 268:429, 1995
53. Purvis SF, Jacobberger JW, Sramkoski RM, Patki AG, Lederman MM: HIV type 1 Tat protein induces apoptosis and death in Jurkat cells. AIDS Res Hum Retroviruses 11:443, 1995
54. Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin K-M, Krammer PH: Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 375:497, 1995
55. Banda NK, Bernier J, Kurahara DK, Kurrle R, Haigwood N, Sekaly R-P, Finkel TH: Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J Exp Med 176:1099, 1992
56. Aldrovandi G, Feuer G, Gao L, Jamieson B, Kristeva M, Chen ISY, Zack JA: The SCID-hu mouse as a model for HIV-1 infection. Nature 363:732, 1993
57. Bonyhadi ML, Rabin L, Salimi S, Brown DA, Kosek J, McCune JM, Kaneshima H: HIV induces thymus depletion in vivo. Nature 363:728, 1993
58. Ameisen JC, Capron A: Cell dysfunction and depletion in AIDS: The programmed cell death hypothesis. Immunol Today 12:102, 1991
59. Tewari M, Dixit VM: Fas-and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem 270:3255, 1995