A potential vulnerability locus for schizophrenia on chromosome 6p24–22: Evidence for genetic heterogeneity

Nature Genetics

Volumn 11, Issue 3, 1995, Pages 287-293

  Straub, Richard E ^a   MacLean, Charles J ^a   O'Neill, F Anthony ^b   Burke, John ^c,d   Murphy, Bernadette ^c   Duke, Fiona ^b   Shinkwin, Rosemarie ^c   Webb, Bradley T ^a   Zhang, Jie ^a   Walsh, Dermot ^c   Kendler, Kenneth S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c HEALTH RESEARCH BOARD   (Ireland)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 6P; CHROMOSOME MARKER; FAMILY STUDY; GENE LOCUS; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; IRELAND; MAJOR CLINICAL STUDY; PEDIGREE; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA;

CHROMOSOMES, HUMAN, PAIR 6; GENETIC HETEROGENEITY; GENETIC MARKERS; HUMAN; LINKAGE (GENETICS); LOD SCORE; MODELS, GENETIC; PEDIGREE; SCHIZOPHRENIA; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028820161     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1195-287     Document Type: Article

References (59)

1. Gottesman, I.I. & Shields, J. Schizophrenia: The Epigenetic Puzzle. (Cambridge University Press, New York, 1982).
2. Kendler, K.S. The genetics of schizophrenia: an overview. In Handbook of Schizophrenia: Vol. 3: Nosology, Epidemiology, and Genetics. (eds Tsuang, M.T. & Simpson, J.C.) 437 (Elsevier Science Publishers, Amsterdam, The Netherlands, 1988).
3. Kendler, K.S. & Diehl, S.R. The genetics of schizophrenia: A current, genetic-epidemtologic perspective. Schizophr. Bull. 19, 261-285 (1993).
4. O'Rourke, D.H., Gottesman, I.I., Suarez, B.K., Rice, J. & Reich, T. Refutation of the general single-locus model for the etiology of schizophrenia. Am. J. hum. Genet. 34, 630-649 (1982).
5. Prescott, C.A. & Gottesman, I.I. Genetically mediated vulnerability to schizophrenia. [Review]. Psych. Clin. N. Am. 16, 245-267 (1993).
6. Cloninger, C.R. Turning point in the design of linkage studies of schizophrenia. Am. J. med. Genet. 54, 83-92 (1994).
7. O'Donovan, M.C. & Owen, M.J. Advances and retreats in the molecular genetics of major mental illness. Ann. Med. 24, 171-177 (1992).
8. Elston, R.C. P Values, Power, and Pitfalls in the Linkage Analysis of Psychiatric Disorders. InGenetic Approaches to Mental Disorders (ed. Gershon, E.S. & Cloninger, C.R.) 3 (American Psychiatric Press, Inc. Washington, DC, 1994).
9. Risch, N.J. Mapping Genes for Psychiatric Disorders. In Genetic Approaches to Mental Disorders. (eds Gershon, E.S. & Cloninger, C.R.) 47 (American Psychiatric Press Inc., Washington, DC, 1994).
10. Suarez, B.K., Hampe, C.L. & Van Eerdewegh, P. Problems of Replicating Linkage Claims in Psychiatry. In Genetic Approaches to Mental Disorders. (eds Gershon, E.S. and Cloninger, C.R.) 23 (American Psychiatric Press, Washington, DC, 1994).
11. Ott, J. Cutting a Gordian knot in the linkage analysis of complex human traits. Am. J. hum. Genet. 46, 219-221 (1990).
12. Risch, N. Linkage strategies for genetically complex traits. I. Multilocus models. Am. J. hum. Genet. 46, 222-228 (1990).
13. Risch, N. Genetic linkage and complex diseases, with special reference to psychiatric disorders. Genet. Epidemiol. 7, 3-16 (1990).
14. Baron, M. Genetic linkage in mental illness. Nature 346, 618 (1990).
15. Martinez, M.M. & Goldin, L.R. The detection of linkage and heterogeneity in nuclear families for complex disorders: One versus two marker loci. Am. J. hum. Genet. 44, 552-559 (1989).
16. Martinez, M. & Goldin, L.R. Power of the linkage test for a heterogeneous disorder due to two independent inherited causes: a simulation study. Genet. Epidemiol. 7, 219-230 (1990).
17. Chen, W.J., Faraone, S.V. & Tsuang, M.T. Linkage studies of schizophrenia: a simulation study of statistical power. Genet. Epidemiol. 9, 123-139 (1992).
18. Davies, J.L. et al. A genome-wide search for human type 1 diabetes susceptibility genes.Nature 371, 130-136 (1994).
19. Hashimoto, L. et al. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 371, 161-164 (1994).
20. Tanzi, R. et al. Genetic heterogeneity of gene defects responsible for familial Alzheimer disease. Genetica 91, 255-263 (1993).
21. Easton, D.F. et al. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. Am. J. hum. Genet 52, 678-701 (1993).
22. Chromosome 16 Tuberous Sclerosis Consortium. Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75, 1305-1315 (1993).
23. Wang, S. et al. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-6p22. Nature Genet. 10, 41-46 (1995).
24. Kendler, K.K., O'Neill, F.A., Burke, J., Murphy, B., Duke, F., Straub, R.E., Shinkwin, R., NiNuallain, M., MacLean, C.J. & Walsh, D. Irish study of highdensity schizophrenia families: field methods and power to detect linkage. Am. J. med. Genet. (in the press).
25. Kendler, K.S., McGuire, M., Gruenberg, A.M. & Walsh, D. An epidemiologic, clinical, and family study of simple schizophrenia in County Roscommon, Ireland. Am. J. Psych. 151, 27-34 (1994).
26. Kendler, K.S., McGuire, M., Gruenberg, A.M., O'Hare, A., Spellman, M. & Walsh, D. Roscommon family study: I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Archs. gen. Psychiatry 50, 527-540 (1993).
27. Kendler, K.S., McGuire, M., Gruenberg, A.M., Spellman, M., O'Hare, A. & Walsh, D. The Roscommon family study: II. The risk of nonschizophrenic nonaffective psychoses in relatives. Archs. gen. Psychiatry 50, 645-652 (1993).
28. Kendler, K.S., McGuire, M., Gruenberg, A.M., O'Hare, A., Spellman, M. & Walsh, D. The Roscommon family study: III. Schizophrenia-related personality disorders in relatives.Archs. gen. Psychiatry 50, 781-788 (1993).
29. MacLean, C.J., Ploughman, L.M., Diehl, S.R. & Kendler, K.S. A new test for linkage in the presence of locus heterogeneity. Am. J. hum. Genet. 50, 1259-1266 (1992).
30. Volz, A., Boyle, J.M., Cann, H.M., Cottingham, R.W., Orr, H.T. & Ziegler, A. Report of the second international workshop on human chromosome 6. Genomics 21, 464-472 (1994).
31. Martin, M., Mann, D. & Carrington, M. Recombination rates across the HLA complex: use of microsatelHtes as a rapid screen for recombinant chromosomes. Hum. mol. Genet. 4, 423-428 (1995).
32. Smith, C.A.B. Testing for heterogeneity of recombination fraction values in human genetics. Ann. hum. Genet. 27, 175-182 (1963).
33. Lange, K., Weeks, D. & Boehnke, M. Programs for pedigree analysis: MENDEL, FISHER, and dGENE. Genet. Epidemiol. 5, 471-472 (1988).
34. Sandkuijl, L.A. Analysis of affected sib pairs using information from extended families. Prog. clin. Biol. Res. 329, 117-122 (1989).
35. Lander, E.S. & Schork, N.J. Genetic dissection of complex traits. Science 265, 2037-2048 (1994).
36. Baron, M. et al. Genetic linkage between X-chromosome markers and bipolar affective illness. Nature 326, 289-292 (1987).
37. Sherrington, R. et al. Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336, 164-167 (1988).
38. Clerget-Darpoux, F., Bonaiti-Pellie, C. & Hochez, J. Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42, 393-399 (1986).
39. Weeks, D.E., Lehner, T., Squires-Wheeler, E., Kaufmann, C. & Ott, J. Measuring the inflation of the lod score due to its maximization over model parameter values in human linkage analysis. Genet. Epidemiol. 7, 237-243 (1990).
40. Clerget-Darpoux, F., Babron, M.-C. & Bonaïti-Pellié, C. Assessing the effect of multiple linkage tests in complex diseases. Genet. Epidemiol. 7, 245-253 (1990).
41. Risch, N. A note on multiple testing procedures in linkage analysis. Am. J. hum. Genet. 48, 1058-1064 (1991).
42. Hodge, S.E. & Greenberg, D.A. Sensitivity of lod scores to changes in diagnostic status.Am. J. hum. Genet. 50, 1053-1066 (1992).
43. Goldin, L.R., DeLisi, L.E. & Gershon, E.S. Relationship of HLA to schizophrenia in 10 nuclear families. Psychiatry. Res. 20, 69-77 (1987).
44. Wright, P., Gill, M. & Murray, R.M. Schizophrenia: genetics and the maternal immune response to viral infection. Am. J. med. Genet. 48, 40-46 (1993).
45. Risch, N. & Giuffra, L. Model misspecification and multipoint linkage analysis. Hum. Hered.42, 77-92 (1992).
46. Vieland, V.J., Hodge, S.E. & Greenberg, D.A. Adequacy of single-locus approximations for linkage analysis of oligogenic traits. Genet. Epidemiol. 9, 45-59 (1992).
47. Antonarakis, S.E. et al. Follow-up of potential vulnerability locus for schizophrenia on chromosome 6p24-p22. Nature. Genet. 11, 235-236 (1995).
48. Schwab, S.G. et al. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nature Genet. 11, 325-327 (1995).
49. Moises, H.W. et al. An international Two-stage genome wide search for schizophrenia susceptibility genes. Nature Genet. 11, 321-324 (1995).
50. Mowry, B.J. et al. Lack of support for a schizophrenia susceptibility locus on chromosome 6p24-22 Nature Genet. 11, 233-234 (1995).
51. Gurling, H. et al. Negative linkage results for schizophrenia with D6S296 and D6S285.Nature Genet. 11, 234-235 (1995).
52. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised, (The American Psychiatric Association, USA, 1987).
53. Kendler, K.S., McGuire, M., Gruenberg, A.M. & Waish, D. Examining the validity of DSM-III-R schizoaffective disorder and its putative subtypes in the Roscommon family study.Am. J. Psychiatry 152, 755-764 (1995).
54. Spitzer, R.L., Williams, J.B.W., Gibbon, M. & First, M.B. The structured clinical interview forDSM-III-R(SCID): I: History, rationale, and description. Arch. Gen. Psychiatry 49, 624-629 (1992).
55. Kendler, K.S., Lieberman, J.A. & Walsh, D. The structured interview for schizotypy (SIS): a preliminary report. Schizophr. Bull. 15, 559-571 (1989).
56. Straub, R.E. et al. A microsatellite genetic linkage map of human chromosome 18.Genomics 15, 48-56 (1993).
57. Kendler, K.S.andWalsh, D. Gender and schizophrenia: results of an epidemiologically based family study. Br. J. Psych. 167, 184-192 (1995).
58. MacLean, C.J., Sham, P.C., Ploughman, L.M., Diehl, S.R. & Kendler, K.S. Testing for linkage under heterogeneity: A test versus C test. Am. J. hum. Genet. 54, 564-567 (1994).
59. Donis-Keller, H. et al. A genetic linkage map of the human genome. Cell 51, 319-337 (1987).