Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives

Anti-Cancer Drug Design

Volumn 13, Issue 8, 1998, Pages 837-855

  Searcey, Mark ^a,c   McClean, Siobhán ^a,d   Madden, Bernie ^a   McGown, Alan T ^b   Wakelin, Laurence P G ^a,e  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d ELAN PHARMACEUTICALS   (United States)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

9 Anilinoacridine; Chelidamic acid; Cytotoxicity; DNA cleaving agent; DNA threading agent; Footprinting agent; Sequence selectivity

Indexed keywords

9 ANILINOACRIDINE DERIVATIVE; ACRIDINE; AMIDE; CHELIDAMIC ACID DERIVATIVE; FERROUS ION; FREE RADICAL; FTP1; FTP2; HYDROGEN; INTERCALATING AGENT; N,N DIMETHYLAMINOETHYL 4 CARBOXAMIDE; SUGAR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL STRUCTURE; CHROMATOPHORE; CONTROLLED STUDY; CYTOTOXICITY; DISSOCIATION; DNA CLEAVAGE; DNA FOOTPRINTING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IRON BINDING CAPACITY; MULTIDRUG RESISTANCE; OVARY CANCER; PHENOTYPE; PRIORITY JOURNAL;

ACRIDINES; AMSACRINE; ANTINEOPLASTIC AGENTS; DNA; DNA FOOTPRINTING; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; INTERCALATING AGENTS; PICOLINIC ACIDS; PYRIDONES; TUMOR CELLS, CULTURED;

EID: 0032424160     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

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