A mechanism of resistance to HIV-1 entry: Inefficient interactions of CXCR4 with CD4 and gp120 in macrophages

Virology

Volumn 259, Issue 1, 1999, Pages 1-6

  Dimitrov, Dimiter S ^a   Norwood, David ^a   Stantchev, Tzanko S ^b   Feng, Yanru ^a   Xiao, Xiaodong ^a   Broder, Christopher C ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

CD4; Chemokine receptors; Coreceptors; CXCR4; Envelope glycoprotein; HIV 1; Membrane fusion

Indexed keywords

CD4 ANTIGEN; GLYCOPROTEIN GP 120; VIRUS RECEPTOR;

ARTICLE; CELL FUSION; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTE; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; VACCINIA VIRUS; VIRUS RESISTANCE;

EID: 0033587321     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1999.9747     Document Type: Article

References (38)

1. Dimitrov D. S., Broder C. C. HIV and Membrane Receptors. 1997;Landes Biosciences, Austin.
2. Schmidtmayerova H., Alfano M., Nuovo G., Bukrinsky M. Human immunodeficiency virus type 1 T-lymphotropic strains enter macrophages via a CD4- and CXCR4-mediated pathway: Replication is restricted at a postentry level. J. Virol. 72:1998;4633-4642.
3. Broder C. C., Berger E. A. Fusogenic selectivity of the envelope glycoprotein is a major determinant of human immunodeficiency virus type 1 tropism for CD4+ T-cell lines vs. primary macrophages. Proc. Natl. Acad. Sci. USA. 92:1995;9004-9008.
4. Lapham C. K., Ouyang J., Chandrasekhar B., Nguyen N. Y., Dimitrov D. S., Golding H. Evidence for cell-surface association between fusin and the CD4- gp120 complex in human cell lines. Science. 274:1996;602-605.
5. Dimitrov D. S., Xiao X., Chabot D. J., Broder C. C. HIV Coreceptors. J. Membr. Biol. 166:1998;75-90.
6. Broder C. C., Dimitrov D. S. HIV and the 7-transmbembrane domain receptors. Pathobiology. 64:1996;171-179.
7. Berger E. A., Doms R. W., Fenyo E. M., Korber B. T., Littman D. R., Moore J. P., Sattentau Q. J., Schuitemaker H., Sodroski J., Weiss R. A. A new classification for HIV-1. Nature. 391:1998;240.
8. Golding H., Dimitrov D. S., Manischewitz J., Broder C. C., Robinson J., Fabian S., Littman D. R., Lapham C. K. Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules. J. Virol. 69:1995;6140-6148.
9. Dimitrov D. S. Fusin - A place for HIV-1 and T4 cells to meet. Identifying the coreceptor mediating HIV-1 entry raises new hopes in the treatment of AIDS. Nature Med. 2:1996;640-641.
10. Wu L., Gerard N. P., Wyatt R., Choe H., Parolin C., Ruffing N., Borsetti A., Cardoso A. A., Desjardin E., Newman W., Gerard C., Sodroski J. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. Nature. 384:1996;179-183.
11. Trkola A., Dragic T., Arthos J., Binley J. M., Olson W. C., Allaway G. P., Cheng-Mayer C., Robinson J., Maddon P. J., Moore J. P. CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature. 384:1996;184-187.
12. Lapham C. K., Zaitseva M. B., Lee S., Romanstseva T., Golding H. Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5. Nature Med. 5:1999;303-308.
13. Platt E. J., Wehrly K., Kuhmann S. E., Chesebro B., Kabat D. Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1. J. Virol. 72:1998;2855-2864.
14. Kozak S. L., Platt E. J., Madani N., Ferro F. E. Jr., Peden K., Kabat D. CD4, CXCR-4, and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type 1. J. Virol. 71:1997;873-882.
15. Dimitrov D. S. How do viruses enter cells? The HIV-1 coreceptors teach us a lesson of complexity. Cell. 91:1997;721-730.
16. Moriuchi H., Moriuchi M., Arthos J., Hoxie J., Fauci A. S. Promonocytic U937 subclones expressing CD4 and CXCR4 are resistant to infection with and cell-to-cell fusion by T-cell-tropic human immunodeficiency virus type 1. J. Virol. 71:1997;9664-9671.
17. McKnight A., Wilkinson D., Simmons G., Talbot S., Picard L., Ahuja M., Marsh M., Hoxie J. A., Clapham P. R. Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent. J. Virol. 71:1997;1692-1696.
18. Dittmar M. T., McKnight A., Simmons G., Clapham P. R., Weiss R. A., Simmonds P. HIV-1 tropism and co-receptor use. Nature. 385:1997;495-496.
19. LaCasse R. A., Follis K. E., Trahey M., Scarborough J. D., Littman D. R., Nunberg J. H. Fusion-competent vaccines: Broad neutralization of primary isolates of HIV. Science. 283:1999;357-362.
20. Montefiori D., Moore J. HIV vaccines. Magic of the occult. Science. 283:1999;336-337.
21. Simmons G., Reeves J. D., McKnight A., Dejucq N., Hibbitts S., Power C. A., Aarons E., Schols D., De Clercq E., Proudfoot A. E., Clapham P. R. CXCR4 as a functional coreceptor for human immunodeficiency virus type 1 infection of primary macrophages. J. Virol. 72:1998;8453-8457.
22. Verani A., Pesenti E., Polo S., Tresoldi E., Scarlatti G., Lusso P., Siccardi A. G., Vercelli D. CXCR4 is a functional coreceptor for infection of human macrophages by CXCR4-dependent primary HIV-1 isolates. J. Immunol. 161:1998;2084-2088.
23. Yi Y., Rana S., Turner J. D., Gaddis N., Collman R. G. CXCR-4 is expressed by primary macrophages and supports CCR5-independent infection by dual-tropic but not T-tropic isolates of human immunodeficiency virus type 1. J. Virol. 72:1998;772-777.
24. Michael N. L., Nelson J. A., Kewalramani V. N., Chang G., O'Brien S. J., Mascola J. R., Volsky B., Louder M., White G. C., Littman D. R., Swanstrom R., O'Brien T. R. Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32. J. Virol. 72:1998;6040-6047.
25. Di Marzio P., Tse J., Landau N. R. Chemokine receptor regulation and HIV type 1 tropism in monocyte-macrophages. AIDS Res. Hum. Retroviruses. 14:1998;129-138.
26. Sozzani S., Ghezzi S., Iannolo G., Luini W., Borsatti A., Polentarutti N., Sica A., Locati M., Mackay C., Wells T. N., Biswas P., Vicenzi E., Poli G., Mantovani A. Interleukin 10 increases CCR5 expression and HIV infection in human monocytes. J. Exp. Med. 187:1998;439-444.
27. Herbein G., Doyle A. G., Montaner L. J., Gordon S. Lipopolysaccharide (LPS) down-regulates CD4 expression in primary human macrophages through induction of endogenous tumour necrosis factor (TNF) and IL-1 beta. Clin. Exp. Immunol. 102:1995;430-437.
28. Moriuchi M., Moriuchi H., Turner W., Fauci A. S. Exposure to bacterial products renders macrophages highly susceptible to T-tropic HIV-1. J. Clin. Invest. 102:1998;1540-1550.
29. Richman D. D., Bozzette S. A. The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progression. J. Infect. Dis. 169:1994;968-974.
30. Graziosi C., Pantaleo G. The multi-faceted personality of HIV. Nature Med. 3:1997;1318-1320.
31. Broder C. C., Kennedy P. E., Michaels F., Berger E. A. Expression of foreign genes in cultured human primary macrophages using recombinant vaccinia virus vectors. Gene. 142:1994;167-174.
32. Broder C. C., Dimitrov D. S., Blumenthal R., Berger E. A. The block to HIV-1 envelope glycoprotein-mediated membrane fusion in animal cells expressing human CD4 can be overcome by human cell components. Virology. 193:1993;483-491.
33. Feng Y., Broder C. C., Kennedy P. E., Berger E. A. HIV-1 entry cofactor: Functional cDNA cloning of a seven- transmembrane, G protein-coupled receptor. Science. 272:1996;872-877.
34. Carroll, M. W. 1993, Expression, analysis and immunogenicity of human immunodeficiency type Ienvelope glycoprotein in vaccinia virus. PhD. dissertation, University of Manchester, UK.
35. Fuerst T. R., Niles E. G., Studier F. W., Moss B. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA. 83:1986;8122-8126.
36. Earl P. L., Broder C. C., Long D., Lee S. A., Peterson J., Chakrabarti S., Doms R. W., Moss B. Native oligomeric human immunodeficiency virus type 1 envelope glycoprotein elicits diverse monoclonal antibody reactivities. J. Virol. 68:1994;3015-3026.
37. Nussbaum O., Broder C. C., Berger E. A. Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation. J. Virol. 68:1994;5411-5422.
38. Xiao X., Wu L., Stantchev T., Feng Y.-R., Ugolini S., Chen H., Chabot D., Shen Z., Riley J. L., Broder C. C., Sattentau Q. J., Dimitrov D. S. Constitutive cell surface association between CD4 and CCR5. Proc. Natl. Acad. Sci. USA. 1999.