Potentiation of ara-C-induced apoptosis by the protein kinase C activator bryostatin 1 in human leukemia cells (HL-60) involves a process dependent upon c-Myc

Biochemical Pharmacology

Volumn 54, Issue 5, 1997, Pages 563-573

  Chelliah, Jeyananthan ^a   Freemerman, Alex J ^a   Wu Pong, Susanna ^a   Jarvis, W David ^a   Grant, Steven ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antisense oligonucleotides; Apoptosis; ara C; Bryostatin 1; c myc

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BRYOSTATIN 1; CALCIMYCIN; CYTARABINE; MEZEREIN; PROTEIN KINASE C ACTIVATOR;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG POTENTIATION; GENE EXPRESSION; HUMAN; HUMAN CELL; ONCOGENE C MYC; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CYTARABINE; DITERPENES; DNA FRAGMENTATION; DRUG SYNERGISM; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; KINETICS; LACTONES; MACROLIDES; OLIGONUCLEOTIDES, ANTISENSE; PHORBOL 12,13-DIBUTYRATE; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-MYC; TERPENES; TETRADECANOYLPHORBOL ACETATE; THIONUCLEOTIDES;

EID: 0030870605     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00212-8     Document Type: Article

References (57)

1. Kato GJ and Dang CV, Function of the c-Myc oncoprotein. FASEB J 6: 3065-3072, 1992.
2. Iguchi-Ariga SM, Itani T, Kiji Y and Ariga H, Possible function of the c-myc product: Promotion of cellular DNA replication. EMBO J 6: 2365-2371, 1987.
3. Filmus J and Buick RN, Relationship of c-myc expression to differentiation and proliferation of HL-60 cells. Cancer Res 45: 822-825, 1985.
4. DePinho RA, Schreiber-Agus N and Alt FW, myc Family oncogenes in the development of normal and neoplastic cells. Adv Cancer Res 5: 1-38, 1991.
5. Kelly K, Cochran BH, Stiles CD and Leder P, Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35: 603-610, 1983.
6. Westin EH, Wong-Staal F, Gelmann EP, Dalla Favera R, Papas TS, Lautenberger JA, Eva A, Reddy EP, Tronick SR, Aaronson SA and Gallo RC, Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. Proc Natl Acad Sci USA 79: 2490-2494, 1982.
7. Wyllie AH, Glucocorticoid-induced apoptosis is associated with endonuclease activation. Nature 284: 555-556, 1980.
8. Harrington EA, Bennett MR, Fanidi A and Evan GI, c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J 13: 3286-3295, 1994.
9. Askew DS, Ashmun RA, Simmons BC and Cleveland JL, Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6: 1915-1922, 1991.
10. Shi Y, Glynn JM, Guilbert LJ, Cotter TG, Bissonnette RP and Green DR, Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257: 212-214, 1992.
11. Fanidi A, Harrington EA and Evan GI, Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature 359: 554-556, 1992.
12. Cayre Y, Raynal M-C, Darzynkiewicz Z and Dorner MH, Model for intermediate steps in monocytic differentiation: c-myc, C-fms, and ferritin as markers. Proc Natl Acad Sci USA 84: 7619-7623, 1987.
13. Solary E, Bertrand R, Kohn K and Pommier Y, Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors. Blood 81: 1359-1368, 1993.
14. Del Bino G, Li X, Traganos F and Darzynkiewicz Z, Altered susceptibility of differentiating HL-60 cells to apoptosis induced by antitumor drugs. Leukemia 8: 281-288, 1994.
15. Kraft AS, William F, Pettit GR and Lilly MB, Varied differentiation responses of human leukemias to bryostatin 1. Cancer Res 49: 1287-1293, 1989.
16. Grant S, Jarvis WD, Swerdlow PS, Turner AJ, Traylor RS, Wallace HJ, Lin P-S, Pettit GR and Gewirtz DA, Potentiation of the activity of 1-β-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells. Association with enhanced fragmentation of mature DNA. Cancer Res 52: 6270-6278, 1992.
17. Jarvis WD, Povirk LF, Turner AJ, Traylor RS, Gewirtz DA, Pettit GR and Grant S, Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[β-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells. Biochem Pharmacol 47: 839-852, 1994.
18. Grant S, McCrady C, Boise L, Westin EH and Pettit GR, Effects of bryostatin 1 on the metabolism and cytotoxicity of 1-β-D-arabinofuranosylcytosine in human leukemia cells. Biochem Pharmacol 42: 853-867, 1991.
19. Kraft AS, Baker VV and May WS, Bryostatin 1 induces changes in protein kinase C location and activity without altering c-myc expression in human promyelocytic leukemia cells (HL-60). Oncogene 1: 111-118, 1987.
20. Gallegher R, Collins S, Trujillo J, McCredie K, Ahearn M, Tsai S, Metzgar R, Aulakh G, Ting R, Ruscetti F and Gallo R, Characterization of the continuous differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia. Blood 54: 713-734, 1979.
21. Jarvis DW, Kolesnick RW, Fornari FA, Traylor RS, Gewirtz DA and Grant S, Activation of the sphingomyelinase pathway initiates apoptosis in a variety of mammalian cell lines. Proc Natl Acad Sci USA 91: 73-77, 1994.
22. Gavrieli Y, Sherman Y and Ben-Sasson SA, Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501, 1992.
23. Jarvis WD, Turner AJ, Povirk LF, Traylor RS and Grant S, Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res 54: 1707-1714, 1994.
24. Kraft AS, Smith JB and Berkow RL, Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60. Proc Natl Acad Sci USA 83: 1334-1338, 1986.
25. Grant S, Rao A, Freemerman AJ, Turner A, Kornstein M, Chelliah J and Jarvis WD, Divergent effects of calcium ionophore (A23187) on bryostatin 1-related differentiation and apoptosis in human promyelocytic leukemia cells. Mol Cell Differ 3: 337-359, 1995.
26. Wickstrom EL, Bacon TA, Gonzalez A, Freeman DL, Lyman GH and Wickstrom E, Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA. Proc Natl Acad Sci USA 85: 1028-1032, 1988.
27. Crowther PJ, Cooper IA and Woodcock DM, Biology of cell killing by 1-β-D-arabinofuranosylcytosine and its relevance to molecular mechanisms of cytotoxictty. Cancer Res 45: 4291-4300, 1985.
28. Kimura S, Maekawa T, Hirakawa K, Murakami A and Abe T, Alterations of c-myc expression by antisense oligodeoxynucleotides enhance the induction of apoptosis in HL-60 cells. Cancer Res 55: 1379-1384, 1995.
29. Hunter T and Pines J, Cyclins and cancer II: Cyclin D and DCK inhibitors come of age. Cell 79: 573-582, 1994.
30. Ishida S, Shudo K, Takada S and Koike K, A direct role of transcription factor E2F in c-myc gene expression during granulocytic and macrophage-like differentiation of HL-60 cells. Cell Growth Differ 6: 229-237, 1993.
31. Beere HM, Hickman JA, Morimoto RI, Parrnar R, Newbould R and Waters CM, Changes in HSC70 and c-myc in HL-60 cells engaging differentiation or apoptosis. Mol Cell Differ 1: 323-343, 1993.
32. Wood AC, Elvin P and Hickman JA, Induction of apoptosis by anti-cancer drugs with disparate modes ot action: Kinetics of cell death and changes in c-myc expression. Br J Cancer 71: 937-941, 1995.
33. Niimi S, Nakagawa K, Yokota J, Tsunokawa Y, Nishio K, Terashima Y, Shibuya M, Terada M and Saijo N, Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and or c-H-ras genes. Br J Cancer 63: 237-241, 1991.
34. Griep AE and Westphal H, Antisense myc sequences induce differentiation of F9 cells. Proc NadtlAcad Sci USA 85: 6806-6810, 1988.
35. Yokoyama K and Imamoto F, Transcriptional control of the endogenous MYC protooncogene by antisense RNA. Proc Natl Acad Sci USA 84: 7363-7367, 1987.
36. Holt JT, Redner RL and Nienhaus AW, An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation. Mol Cell Biol 8: 963-973, 1988.
37. Wickstrom EL, Bacon TA, Gonzalez A, Lyman GH and Wickstrom E, Anti-c-myc DNA increases differentiation and decreases colony formation by HL-60 cells. In Vitro Cell Dev Biol 25: 297-302, 1989.
38. Ben-Baruch N, Reinhold WC, Alexandrova N, Ichinose I, Blake M, Trepel JB and Zajac-Kaye M, c-myc Down-regulation in suramin-treated HL60 cells precedes growth inhibition but does not trigger differentiation. Mol Pharmacol 46: 73-78, 1994.
39. Zhang W, Grasso L, McClain CD, Gambel AM, Cha Y, Travali S, Deisseroth AB and Mercer WE, p53-Independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res 55: 668-674, 1995.
40. Gu W, Schneider JW, Condorelli G, Kaushai S, Mahdavi V and Nadal-Ginard R, Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72: 309-324, 1993.
41. Kraft AS and Berkow RL, Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor. Biochem Biophys Res Commun 131: 1109-1116, 1985.
42. Isakov N, Galron D, Mustelin T, Pettit GR and Altman A, Inhibition of phorbol ester-induced T cell proliferation by bryostatin 1 is associated with rapid degradation of protein kinase C. J Immunol 150: 1195-1204, 1993.
43. Stone RM, Sariban E, Pettit GR and Kufe DW, Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells. Blood 72: 208-213, 1988.
44. Asiedu C, Biggs J, Lilly M and Kraft AS, Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2. Cancer Res 55: 3716-3720, 1995.
45. Rao A, Freemerman A, Jarvis WD, Chelliah J, Bear HD and Grant S, Effect of AS101 on bryostatin 1-mediated differentiation induction, cell cycle arrest, and modulation of 1-β-D-arabinofuranosylcytosine-related apoptosis in human myeloid leukemia cells. Leukemia 10: 1150-1158, 1996.
46. 1. Mol Cell Biol 8: 1614-1624, 1988.
47. Hoffman B and Liebermann DA, Molecular controls of apoptosis: Differentiation/growth arrest primary response genes, proto-oncogenes, and tumor suppressor genes as positive & negative modulators. Oncogene 9: 1807-1812, 1994.
48. Packham G and Cleveland JL, c-Myc and apoptosis. Biochim Biophys Acta 1242: 11-28, 1995.
49. Evan G and Littlewood TD, The role of c-myc in cell growth. Curr Opin Genet Dev 3: 44-49, 1994.
50. Lotem J, Cragoe EJ and Sachs L, Rescue from programmed cell death in leukemia and normal cells. Blood 78: 953-960, 1991.
51. Bernstein SH, Kharbanda SM, Sherman ML, Stone RM and Kufe DW, Inhibition of protein kinase C is associated with a decrease in c-myc expression in human myeloid leukemia cells. FEBS Lett 294: 73-76, 1991.
52. Wolf D and Rotter V, Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells. Proc Natl Acad Sci USA 82: 790-794, 1985.
53. Selvakumaran M, Liebermann D and Hoffman B, The protooncogene c-myc blocks myeloid differentiation independently of its target gene ornithine decarboxylase. Blood 88: 1248-1255, 1996.
54. Galaktionov K, Chen X and Beach D, Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382: 511-517, 1996.
55. Hermeking H and Eick D, Mediation of c-Myc-induced apoptosis by p53. Science 265: 2091-2093, 1994.
56. Collins S and Groudine M, Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line. Nature 298: 679-681, 1982.
57. 1. inhibits ara-C-induced CPP32/ Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells. Cancer Res 56: 4743-4748, 1996.