Aminoethylprolyl peptide nucleic acids (aepPNA): Chiral PNA analogues that form highly stable DNA:aepPNA2 triplexes

Organic Letters

Volumn 1, Issue 10, 1999, Pages 1513-1516

  D'Costa, Moneesha ^a   Kumar, Vaijayanti A ^a   Ganesh, Krishna N ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; OLIGODEOXYRIBONUCLEOTIDE; PEPTIDE NUCLEIC ACID; TRIPLEX DNA;

ARTICLE; CHEMISTRY; CONFORMATION; SYNTHESIS;

DNA; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; PEPTIDE NUCLEIC ACIDS;

EID: 0033581785     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol990835i     Document Type: Article

References (24)

1. (a) Nielsen, P. E. Annu. Rev. Biophys. Biomol. Struct. 1995, 24, 167-183.
2. (b) Hyrup, B.; Nielsen, P. E. Bioorg. Med. Chem. Lett. 1996, 4, 5-23.
3. (c) Good, L.; Nielsen, P. E. Antisense Nucleic Acids Drug Develop. 1997, 7, 431-437
4. (d) Uhlmann, E.; Peyman, A.; Breipohl, G.; Will, D. W. Angew. Chem. Int. Ed. 1998, 37, 2796-2823.
5. Egholm, M.; Buchardt, O.; Christensen, L.; Behrens, C.; Freier, S. M.; Driver, D. A.; Berg, R. H.; Kim, S. K.; Norden, B.; Nielsen, P. E. Nature 1993, 365, 566-568.
6. Hanvey, J. C.; Peffer, N. J.; Bisi, J. E.; Thomson, S. A.; Cadilla, R.; Josey, J. A.; Ricca, D. J.; Hassman, F.; Bonham, M. A.; Au, K. G.; Carter, S. G.; Bruckenstein, D. A.; Boyd, A. L.; Noble, S. A.; Babiss, L. E. Science 1992, 258, 1481-1485.
7. Kim, S. H.; Nielsen, P. E.; Egholm, M.; Buchardt, O. J. Am. Chem. Soc. 1993, 115, 6477-6489.
8. Koch, T.; Naesby, M.; Wittung, P.; Jørgensen, M.; Larsson, C.; Buchardt, O.; Stanley, C. J.; Nordén, B.; Nielsen, P. E.; Ørum, H. Tetrahedron Lett. 1995, 36, 6933-6936.
9. (a) Petersen, K. H.; Jensen, D. K.; Nielsen, P. E.; Egholm, M.; Buchardt, O. Bioorg. Med. Chem. Lett. 1995, 5, 1119-1124.
10. (b) Bergmann, F.; Bannwarth, W.; Tam, S. Tetrahedron Lett. 1995, 36, 6823-6826.
11. Haaima, G.; Lohse, O.; Buchardt, O.; Nielsen, P. E. Angew. Chem., Int. Ed. Engl. 1996, 35, 1939-1941.
12. (a) Gangamani, B. P.; Kumar, V. A.; Ganesh, K. N. Tetrahedron 1996, 52, 15017-15030.
13. (b) Gangamani, B. P.; Kumar, V. A.; Ganesh, K. N. Tetrahedron 1999, 55, 177-192.
14. (c) Jordan, S.; Schwemler, C.; Winfried, K.; Kretschmer, A.; Schwenner, E.; Stropp, U.; Mielke, B. Bioorg. Med. Chem. Lett. 1997, 7, 681-686, 687-690.
15. Gangamani, B. P.; Kumar, V. A.; Ganesh, K. N. Biochem. Biophys. Res. Commun. 1997, 240, 778-782.
16. Hyrup, B.; Egholm, M.; Buchardt, O.; Nielsen, P. E. Bioorg. Med. Chem. Lett. 1996, 6, 1083-1088.
17. Lowe, G.; Vilaivan, T.; Westwell, M. S. Bioorg. Chem. 1997, 25, 321-329.
18. Lowe, G.; Vilaivan, T. J. Chem. Soc., Perkin Trans, 1 1997, 539-546.
19. 3OH).
20. 3OH).
21. Fields, G. B.; Fields, C. G. J. Am. Chem. Soc. 1991, 113, 4202-4207.
22. Gait, M. J. Oligonucleotide Synthesis, a Practical Approach; IRL Press Limited: Oxford, 1984.
23. Linkletter, B. A.; Szabo, I. E.; Bruice, T. C. J. Am. Chem. Soc. 1999, 121, 3888-3896.
24. Ishihara, T.; Corey, D. R. J. Am. Chem. Soc. 1999, 121, 2012-2020.