Ireland-Claisen rearrangement for the stereoselective formation of the C2-C3 bond in taxanes

Tetrahedron Letters

Volumn 40, Issue 25, 1999, Pages 4659-4662

  Magnus, Philip ^a   Westwood, Nicholas ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TAXANE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 0033581019     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00828-X     Document Type: Article

References (41)

1. 1. Paclitaxel is the generic name for Taxol, which is now a registered trademark. For the isolation and structure see: Wani, M. C.; Taylor, H. L.; Wall, M. E.; Coggon, P.; McPhail, A. T. J. Am. Chem. Soc. 1971, 93, 2327.
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41. 11. The absolute stereochemistry of 19 was deduced from an X-ray structure of its S-(-)-α-methylbenzylamide derivative.