The yeast Cryptococcus neoformans uses 'mammalian' enhancer sites in the regulation of the virulence gene, CNLAC1

Gene

Volumn 227, Issue 2, 1999, Pages 231-240

  Zhang, Shirong ^a   Varma, Ashou ^b   Williamson, Peter R ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Sect Clin and Exp Neuropsychol   (United States)

Author keywords

AIDS; Cryptococcosis; Laccase; Regulation; Transcription; Virulence

Indexed keywords

LACCASE; MESSENGER RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DNA BINDING; ENHANCER REGION; GENETIC TRANSCRIPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPPORTUNISTIC INFECTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRULENCE;

ANIMALS; CRYPTOCOCCUS NEOFORMANS; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; LACCASE; MAMMALS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; OXIDOREDUCTASES; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; VIRULENCE;

ANIMALIA; EUKARYOTA; FILOBASIDIELLA NEOFORMANS; FUNGI; MAMMALIA; PLANTAE;

EID: 0033580279     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(98)00590-3     Document Type: Article

References (39)

1. Alic M., Akileswaran L., Gold M.H. Characterization of the gene encoding manganese peroxidase isozyme 3 from Phanerochaete chrysosporium. Biochim. Biophys. Acta. 1338:1997;1-7.
2. Alspaugh J.A., Perfect J.R., Heitman J. Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes Dev. 11:1997;3206-3217.
3. Bourbonnais R., Paice M.G. Oxidation of non-phenolic substrates. An expanded role for laccase in lignin biodegradation. FEBS Lett. 267:1990;99-102.
4. Chasakes S., Tyndall R.L. Pigment production by Cryptococcus neoformans from para- and ortho-di-phenols: effect of the nitrogen source. J. Clin. Microbiol. 1:1975;509-514.
5. Cochran M.D., Weissmann C. Modular structure of the beta-globin and the TK promoters. EMBO J. 3:1984;2453-2459.
6. Courey A.J., Tjian R. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell. 55:1988;887-898.
7. Edman J.C., Kwon-Chung K.J. Isolation of the URA5 gene from Cryptococcus neoformans var. neoformans and its use as a selective marker for transformation. Mol. Cell. Biol. 10:1990;4538-4544.
8. Godfrey B.J., Akileswaran L., Gold M.H. A reporter gene construct for studying the regulation of manganese peroxidase gene expression. Appl. Environ. Microbiol. 60:1994;1353-1358.
9. Jacobson E.S., Emery H.S. Temperature regulation of the cryptococcal phenoloxidase. J. Med. Vet. Mycol. 29:1991;121-124.
10. Kunzler M., Braus G.H., Geogiev O., Seipel K., Schaffner W. Functional differences between mammalian transcription activation domains at the yeast GAL1 promoter. EMBO J. 13:1994;641-645.
11. Kwon-Chung K.J. Fate of transformed DNA in pathogenic fungi. J. Med. Vet. Mycol.Suppl. 36(Suppl. 1):1998;38-44.
12. Kwon-Chung, K.J., Bennett, J.E., 1992. Cryptococcosis. Lea and Febiger, Philadelphia.
13. Kwon-Chung K.J., Rhodes J.C. Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans. Infect. Immun. 51:1986;218-223.
14. Kwon-Chung K.J., Polacheck I., Popkin T.J. Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice. J. Bacteriol. 150:1982;1414-1421.
15. Liu, L., Wakamatsu, K., Ito, S., Williamson, P.R., 1998. Role of laccase in the virulence of Cryptococcus neoformans, 98th general meeting of the American Society for Microbiology, Atlanta.
16. Lodge, J.K., 1998. Development of signature-tagged mutagenesis in Cryptococcus neoformans, 98th General Meeting, American Society for Microbiology. ASM, Atlanta.
17. Lopez-Rodriquez C., Botella L., Corbi A.L. CCAAT-enhancer-binding proteins (C/EBP) regulate the tissue specific activity of the CD11c integrin gene promoter through functional interactions with Sp1 proteins. J. Biol. Chem. 272:1997;29120-29126.
18. Lue N.F., Kornberg R.D. Accurate initiation at RNA polymerase II promoter in extracts from Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 84:1987;8839-8843.
19. Muller M.M., Gerster T., Schaffner W. Enhancer sequences and the regulation of gene transcription. Eur. J. Biochem. 176:1988;485-495.
20. Nasmyth K. At least 1400 base pairs of 5′-flanking DNA is required for the correct expression of the HO gene in yeast. Cell. 42:1985;213-223.
21. Nurudeen T.A., Ahearn D.G. Regulation of melanin production by Cryptococcus neoformans. J. Clin. Microbiol. 10:1979;724-729.
22. Perez de la Ossa P., Grana X., Ruiz-Lozano P., Climent F. Isolation and characterization of cofactor-independent phosphoglycerate mutase gene from maize. Biochem. Biophys. Res. Comm. 203:1994;1204-1209.
23. Pinner R.W., Hajjeh R.A., Powderly W.G. Prospects for preventing cryptococcosis in persons infected with human immunodeficiency virus. Clin. Infect. Dis. 21(Suppl. 1):1995;S103-S107.
24. Polacheck I., Kwon-Chung K.J. Melanogenesis in Cryptococcus neoformans. J. Gen. Microbiol. 134:1988;1037-1041.
25. Ponticelli A.S., Pardee T.S., Struhl K. The glutamine-rich activation domains of human Sp1 do not stimulate transcription in Saccharomyces cerevisiae. Mol. Cell Biol. 15:1995;983-988.
26. Remacle J.E., Albrecht G., Brys R., Braus G.H., Huylebroeck D. Three classes of mammalian transcription activation domain stimulate transcription in Schizosaccharomyces pombe. EMBO J. 16:1997;5722-5729.
27. Rhodes J.C., Polacheck I., Kwon-Chung K.J. Phenoloxidase activity and virulence in isogenic strains of Cryptococcus neoformans. Infect. Immun. 36:1982;1175-1184.
28. Salas S.D., Bennett J.E., Kwon-Chung K.J., Perfect J.R., Williamson P.R. Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans. J. Exp. Med. 184:1996;377-386.
29. Slansky J.E., Farnham P.J. Introduction to the E2F family: protein structure and gene regulation. Curr. Top. Microbiol. Immunol. 208:1996;1-30.
30. Spitzer E.D., Spitzer S.G., Freundlich L.F., Casadevall A. Persistence of initial infection in recurrent Cryptococcus neoformans meningitis. Lancet. 341:1993;595-596.
31. Staib F. Cryptococcus neoformans and Guizotia abyssinica (syn. G. oleifera DC.) (farbreadktion fur C. neoformans). Z. Hyg. 148:1962;466-475.
32. Struhl K. The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast. Nature. 332:1988;649-650.
33. Torres-Guererro H., Edman J.C. Melanin-deficient mutants of Cryptococcus neoformans. J. Med. Vet. Mycol. 32:1994;303-313.
34. Varma A., Kwon-Chung K.J. Rapid method to extract DNA from Cryptococcus neoformans. J. Clin. Microbiol. 29:1991;810-812.
35. Varma A., Kwon-Chung K.J. Construction of stable episomes in Cryptococcus neoformans. Curr. Genet. 34:1998;60-66.
36. Vemu S., Reichel R.R. Cell cycle regulation of a novel DNA binding complex in Saccharomyces cerevisiae with E2F-like properties. J. Biol. Chem. 270:1995;20724-20729.
37. Wade D.P., Puckey L.H., Knight B.L., Acquati F., Mihalich A., Taramelli R. Characterization of multiple enhancer regions upstream of the apolipoprotein(a) gene. J. Biol. Chem. 272:1997;30387-30399.
38. Wang K., Bohren K.M., Gabbay K.H. Characterization of the human aldose reductase gene promoter. J. Biol. Chem. 268:1993;16052-16058.
39. Williamson P.R. Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase. J. Bacteriol. 176:1994;656-664.