Histidine77, glutamic acid81, glutamic acid123, threonine126, asparagine194, and tryptophan197 of the human emopamil binding protein are required for in vivo sterol Δ8-Δ7 isomerization

Biochemistry

Volumn 38, Issue 3, 1999, Pages 1119-1127

  Moebius, Fabian F ^a,b   Soellner, Kristina E M ^a   Fiechtner, Birgit ^a   Huck, Christian W ^a   Bonn, Günther ^a   Glossmann, Hartmut ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; BINDING PROTEIN; EMOPAMIL; GLUTAMIC ACID; HISTIDINE; IFENPRODIL; ISOMERASE; STEROL; THREONINE; TRYPTOPHAN; ALANINE; AMINO ACID; CARRIER PROTEIN; DELTA(8) DELTA(7) STEROL ISOMERASE; DELTA(8)-DELTA(7)-STEROL ISOMERASE; EBP PROTEIN, HUMAN; ISOENZYME; LATHOSTEROL DELTA 5 DEHYDROGENASE; LATHOSTEROL DELTA-5-DEHYDROGENASE; OXIDOREDUCTASE; PEPTIDE FRAGMENT; PIPERIDINE DERIVATIVE; STEROID DELTA ISOMERASE; STEROL DELTA 5 DESATURASE; STEROL DELTA-5 DESATURASE;

ALPHA HELIX; ARTICLE; CATALYSIS; ISOMERISM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS; STEROL SYNTHESIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BIOSYNTHESIS; CELL MEMBRANE; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO ACIDS; ASPARAGINE; CARRIER PROTEINS; CELL MEMBRANE; GLUTAMIC ACID; HISTIDINE; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PEPTIDE FRAGMENTS; PIPERIDINES; SACCHAROMYCES CEREVISIAE; STEROID ISOMERASES; THREONINE; TRYPTOPHAN;

EID: 0033579697     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981804i     Document Type: Article

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