Solid-phase strategies for the assembly of template-based protein mimetics

Journal of Organic Chemistry

Volumn 64, Issue 19, 1999, Pages 7114-7120

  Peluso, Stéphane ^a   Dumy, Pascal ^a   Nkubana, Céline ^a   Yokokawa, Yoshihiro ^a   Mutter, Manfred ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; MOLECULAR MODEL; PEPTIDE SYNTHESIS; PROTEIN ASSEMBLY; PROTEIN FOLDING; REACTION ANALYSIS; STEREOCHEMISTRY; TECHNIQUE;

EID: 0033578951     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo990669s     Document Type: Article

References (68)

1. Abbreviations: AAA, amino acid analysis; Alloc, allyloxycarbonyl; Dde, 1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl; DIEA, N,N-diisopropylethylamine; ES-MS, electrospray mass spectroscopy; Fmoc, 9-(fluorenylmethyloxycarbonyl); HATU, O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; HBTU, O-(benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; NMM, N-methylmorpholine; PAL, 5-(4-(aminomethyl)-3,5-dimethoxyphenoxy) valeric acid; PEG-PS, poly(ethylene glycol)-polystyrene graft resin support; pNZ, p-nitrobenzyloxycarbonyl; PS, polystyrene resin support; PyAOP, (7-azabenzotriazol-1-yloxy)tris(pyrrolidino)phosphonium hexafluorophosphate; PyBOP, (benzotriazol-1-yloxy)tris (pyrrolidino)phosphonium hexafluorophosphate; RAFT, regioselectively addressable functionalized template; RP-HPLC, reversed-phase high performance liquid chromatography; SASRIN, 2-methoxy-4-alkoxybenzyl alcohol resin; SPPS, solid-phase peptide synthesis; Suc, succinyl; TASP, template-assembled synthetic protein; Trt, triphenylmethyl (trityl); XAL, 9-amino-xanthen-3-yloxymethyl; Xaa, Xbb, amino acid. Amino acid symbols denote the L-configuration.
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