Growth suppression by an E2F-binding defective retinoblastoma protein (RB): Contribution from the RB C pocket

Molecular and Cellular Biology

Volumn 18, Issue 7, 1998, Pages 4032-4042

  Whitaker, Laura L ^a   Su, Heyun ^a   Baskaran, Rajasekaran ^a   Knudsen, Erik S ^a   Wang, Jean Y J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; GENE CONTROL; GENE MUTATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

EID: 0031862730     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.7.4032     Document Type: Article

References (37)

1. Baskaran, R., G. Chiang, T. Mysliwiec, G. Krul, and J. Y. J. Wang. 1997. Tyrosine phosphorylation of RNA polymerase II carboxyl-terminal domain by Abl-related gene (Arg) encoded tyrosine kinase. J. Biol. Chem. 272: 18905-18909.
2. Baskaran, R., G. G. Chiang, and J. Y. J. Wang. 1996. Identification of a binding site in c-Abl tyrosine kinase for the C-terminal repeated domain of RNA polymerase II. Mol. Cell. Biol. 16:3361-3369.
3. Brehm, A., E. Miska, D. McCane, J. Reid, A. Bannister, and T. Kouzarides. 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597-601.
4. Duyster, J., R. Baskaran, and J. Y. J. Wang. 1995. Src homology 2 domain as a specificity determinant in the c-Abl mediated tyrosine phosphorylation of the RNA polymerase II carboxyl-terminal repeated domain. Proc. Natl. Acad. Sci. USA 92:1555-1559.
5. Hiebert, S. W. 1993. Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression. Mol. Cell. Biol. 13:3384-3391.
6. Hinds, P. W., S. Mittnacht, V. Dulic, A. Arnold, S. I. Reed, and R. A. Weinberg. 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70:993-1006.
7. Hurford, R. K., D. Cobrinik, M.-H. Lee, and N. Dyson. 1997. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11:1447-1463.
8. Janicke, R. U., P. A. Walker, X. Y. Lin, and A. G. Porter. 1996. Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J. 15:6969-6978.
9. Knudsen, E. S., and J. Y. J. Wang. 1996. Differential regulation of retinoblastoma protein function by specific cdk phosphorylation sites. J. Biol. Chem. 271:8313-8320.
10. Kratzke, R. A., G. A. Otterson, A. Hogg, A. B. Coxon, J. Geradts, J. K. Cowell, and F. J. Kaye. 1994. Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors. Oncogene 9:1321-1326.
11. Lee, J.-O., A. Russo, and N. Pavletich. 1998. Structure of the retinoblastoma tumor suppressor pocket domain bound to a peptide from HPV E7. Nature 391:859-865.
12. Lees, E., B. Faha, V. Dulic, S. I. Reed, and E. Harlow. 1992. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev. 6:1874-1885.
13. Lohmann, D., B. Brandt, W. Hooping, E. Passarge, and B. Horsthemke. 1994. Distinct Rb1 gene mutations with low penetrance in hereditary retinoblastoma. Hum. Genet. 94:349-354.
14. Luo, R., A. Postigo, and D. Dean. 1998. RB interacts with histone deacetylase to repress transcription. Cell 92:463-473.
15. Magnaghi-Jaulin, L., R. Groisman, I. Maguibneva, P. Robin, S. Lorain, J. L. Villain, F. Troalen, D. Trouche, and A. Harel-Bellan. 1998. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601-605.
16. Mudryj, M., S. H. Devoto, S. W. Hiebert, T. Hunter, J. Pines, and J. R. Nevins. 1991. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell 65:1243-1253.
17. Qin, X.-Q., T. Chittenden, D. M. Livingston, and W. G. Kaelin, Jr. 1992. Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev. 6:953-964.
18. Scheffner, M., K. Munger, J. Byrne, and P. Howley. 1991. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc. Natl. Acad. Sci. USA 88:5523-5527.
19. Sellers, W., B. Novitch, S. Miyake, A. Heith, G. Otterson, F. Kaye, A. Lassar, and W. G. Kaelin, Jr. 1998. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation and suppress tumor cell growth. Genes Dev. 12:95-106.
20. Sellers, W. R., and W. G. Kaelin, Jr. 1996. RB as a modulator of transcription. Biochim. Biophys. Acta 1288:1-5.
21. Sellers, W. R., J. W. Rodgers, and W. G. Kaelin, Jr. 1995. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc. Natl. Acad. Sci. USA 92:11544-11548.
22. Sherr, C. 1996. Cancer cell cycles. Science 274:1672-1677.
23. Slanksy, J. E., and P. J. Farnham. 1996. Introduction to the E2F family: protein structure and gene regulation. Curr. Top. Microbiol. Immunol. 208: 1-30.
24. Tan, X.-Q., H. Su, and J. Y. J. Wang. Unpublished data.
25. Tan, X.-Q., and J. Y. J. Wang. 1998. The caspase-RB connection in cell death. Trends Cell Biol. 8:116-120.
26. Templeton, D. J., S. H. Park, L. Lanier, and R. A. Weinberg. 1991. Non-functional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering. Proc. Natl. Acad. Sci. USA 88:3033-3037.
27. Wang, J. Y. J. 1997. Retinoblastoma protein in growth suppression and death protection. Curr. Opin. Genet. Dev. 7:39-45.
28. Wang, J. Y. J., E. S. Knudsen, and P. J. Welch. 1994. The retinoblastoma tumor suppressor protein. Adv. Cancer Res. 64:25-85.
29. Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
30. Weintraub, S. J., K. N. B. Chow, R. X. Luo, S. H. Zhang, S. He, and D. C. Dean. 1995. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375:812-815.
31. Welch, P. J., and J. Y. J. Wang. 1995. Abrogation of retinoblastoma protein function by c-Abl through ryrosine kinase-dependent and -independent mechanisms. Mol. Cell. Biol. 15:5542-5551.
32. Welch, P. J., and J. Y. J. Wang. 1993. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 75:779-790.
33. Welch, P. J., and J. Y. J. Wang. 1995. Disruption of retinoblastoma protein function by coexpression of its C pocket fragment. Genes Dev. 9:31-46.
34. Welch, P. J., and J. Y. J. Wang. Unpublished data.
35. Xiao, Z.-X., J. Chen, A. Levine, N. Modjtahedi, J. Xing, W. R. Sellers, and D. M. Livingston. 1995. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375:694-698.
36. Zacksenhaus, E., Z. Jiang, D. Chung, J. D. Marth, R. A. Phillips, and B. L. Gallie. 1996. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev. 10:3051-3064.
37. Zhu, L., S. van den Heuvel, K. Helin, A. Fattaey, M. Ewen, D. Livingston, N. Dyson, and E. Harlow. 1993. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 7:1111-1125.