Cytochrome P450-dependent desaturation of lauric acid: Isoform selectivity and mechanism of formation of 11-dodecenoic acid

Chemico-Biological Interactions

Volumn 110, Issue 1-2, 1998, Pages 103-121

  Guan, Xiangming ^a   Fisher, Michael B ^a   Lang, Dieter H ^a   Zheng, Yi Min ^a   Koop, Dennis R ^b   Rettie, Allan E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cytochrome P450; Dehydrogenation; Isotope effect; Lauric acid; Mechanism; Rabbit liver

Indexed keywords

CYTOCHROME P450; HEMOPROTEIN; ISOTOPE; LAURIC ACID; VALPROIC ACID;

ANIMAL CELL; ARTICLE; DEALKYLATION; DRUG EFFECT; DRUG MECHANISM; DRUG METABOLISM; ENZYME SUBSTRATE; FATTY ACID DESATURATION; HYDROGENATION; LIVER TOXICITY; NONHUMAN; RABBIT;

ACETONE; ANIMALS; AROCLOR 1254; AROCLORS; ARYL HYDROCARBON HYDROXYLASES; CARCINOGENS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FATTY ACIDS, MONOUNSATURATED; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; ISOENZYMES; LAURIC ACIDS; MICROSOMES, LIVER; NADP; PHENOBARBITAL; RABBITS; RIFAMPIN; STEREOISOMERISM;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0031918678     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(97)00145-2     Document Type: Article

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