1H/15N HSQC NMR studies of ligand carboxylate group interactions with arginine residues in complexes of brodimoprim analogues and Lactobacillus casei dihydrofolate reductase

Biochemistry

Volumn 38, Issue 7, 1999, Pages 2127-2134

  Morgan, William D ^a   Birdsall, Berry ^a   Nieto, Pedro M ^a   Gargaro, Angelo R ^a   Feeney, James ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BRODIMOPRIM; CARBOXYLIC ACID DERIVATIVE; DIHYDROFOLATE REDUCTASE; CARBOXYLIC ACID; DRUG DERIVATIVE; ENZYME INHIBITOR; FOLIC ACID ANTAGONIST; LIGAND; NITROGEN; PROTON; TRIMETHOPRIM;

ARTICLE; BINDING SITE; COMPLEX FORMATION; COMPUTER MODEL; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; ENZYME BINDING; HYDROGEN BOND; LACTOBACILLUS CASEI; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME; STRUCTURE ACTIVITY RELATION; TEMPERATURE DEPENDENCE; CHEMISTRY; ENZYMOLOGY; MACROMOLECULE; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

ARGININE; CARBOXYLIC ACIDS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; LACTOBACILLUS CASEI; LIGANDS; MACROMOLECULAR SUBSTANCES; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTONS; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM;

EID: 0033573796     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982359u     Document Type: Article

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