Tolerance of 5-fluorodeoxyuridine resistant human thymidylate synthases to alterations in active site residues

Nucleic Acids Research

Volumn 27, Issue 18, 1999, Pages 3702-3711

  Landis, Daniel M ^a   Gerlach, Jay L ^a   Adman, Elinor T ^a   Loeb, Lawrence A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLOXURIDINE; LEUCINE; THYMIDYLATE SYNTHASE; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; ESCHERICHIA COLI; GENETIC COMPLEMENTATION; GENETIC SELECTION; HUMAN; HUMAN CELL; HYDROPHOBICITY; MUTAGENESIS; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; ANTIMETABOLITES, ANTINEOPLASTIC; BINDING SITES; CATALYSIS; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; ESCHERICHIA COLI; FLOXURIDINE; GENE LIBRARY; GENETIC COMPLEMENTATION TEST; HUMANS; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; SELECTION (GENETICS); SEQUENCE ANALYSIS, DNA; STATISTICAL DISTRIBUTIONS; THYMIDYLATE SYNTHASE;

EID: 0033568505     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/27.18.3702     Document Type: Article

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