Inhaled nitric oxide in cardiology practice

Cardiovascular Research

Volumn 43, Issue 3, 1999, Pages 628-638

  Hayward, Christopher S ^a   Kelly, Raymond P ^b   MacDonald, Peter S ^b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ST VINCENT S HOSPITAL   (Australia)

Author keywords

Nitric oxide; Pulmonary circulation

Indexed keywords

NITRIC OXIDE;

CARDIOLOGY; CARDIOVASCULAR SYSTEM; CELL ADHESION; CLINICAL PRACTICE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MECHANISM; DRUG MONITORING; DRUG SAFETY; DRUG SELECTIVITY; HEART VENTRICLE FUNCTION; HUMAN; LEUKOCYTE; LUNG CIRCULATION; LUNG INJURY; LUNG TRANSPLANTATION; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REVIEW; THROMBOCYTE; TREATMENT PLANNING; VASODILATATION;

CELL ADHESION; ENDOTHELIUM, VASCULAR; HEART DISEASES; HEART FAILURE, CONGESTIVE; HUMANS; HYPERTENSION, PULMONARY; LEUKOCYTES; NITRIC OXIDE; PLATELET AGGREGATION; POSTOPERATIVE COMPLICATIONS; VASODILATION; VENTRICULAR FUNCTION;

EID: 0033566865     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(99)00114-5     Document Type: Review

References (136)

1. 2: oxidant air pollutants and more. Environ Health Perspect. 102:(Suppl 10):1994;179-184.
2. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 43:1991;109-143.
3. Frostell C., Fratacci M.D., Wain J.C., Jones R., Zapol W.M. Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation. 83:(6):1991;2038-2047.
4. Pepke-Zaba J., Higenbottam T.W., Dinh-Xuan A.T., Stone D., Wallwork J. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet. 338:(8776):1991;1173-1174.
5. Roberts J.D., Polaner D.M., Lang P., Zapol W.M. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 340:(8823):1992;818-819.
6. Kinsella J.P., Neish S.R., Shaffer E., Abman S.H. Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 340:(8823):1992;819-820.
7. Rossaint R., Pison U., Gerlach H., Falke K.J. Inhaled nitric oxide: its effects on pulmonary circulation and airway smooth muscle cells. Eur Heart J. 14:(Suppl I):1993;133-140.
8. Hogman M., Frostell C.G., Hedenstrom H., Hedenstierna G. Inhalation of nitric oxide modulates adult human bronchial tone. Am Rev Respir Dis. 148:(6 Pt 1):1993;1474-1478.
9. Germann P., Ziesche R., Leitner C., et al. Addition of nitric oxide to oxygen improves cardiopulmonary function in patients with severe COPD. Chest. 114:(1):1998;29-35.
10. Takahashi Y., Kobayashi H., Tanaka N., et al. Worsening of hypoxemia with nitric oxide inhalation during bronchospasm in humans. Respir Physiol. 112:(1):1998;113-119.
11. Gibson Q.H., Roughton F.J.W. The kinetics and equilibria of the reaction of nitric oxide with sheep haemoglobin. J Physiol. 136:1957;507-526.
12. Rimar S., Gillis C.N. Selective pulmonary vasodilation by inhaled nitric oxide is due to hemoglobin inactivation. Circulation. 88:(6):1993;2884-2887.
13. Finkel M.S., Oddis C.V., Jacob T.D., et al. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science. 257:1992;387-389.
14. Mohan P., Brutsaert D.L., Sys S.U. Myocardial performance is modulated by interaction of cardiac endothelium derived nitric oxide and prostaglandins. Cardiovasc Res. 29:1995;637-640.
15. Michel T., Smith T.W. Nitric oxide synthases and cardiovascular signalling. Am J Cardiol. 72:1993;33C-38C.
16. Balligand J.-L., Ungureanu D., Kelly R.A., et al. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. J Clin Invest. 91:1993;2314-2319.
17. Brady A.J.B., Warren J.B., Poole-Wilson P.A., Williams T.J., Harding S.E. Nitric oxide attenuates cardiac myocyte contraction. Am J Physiol. 265:1993;H176-H182.
18. de Belder A.J., Radomski M.W., Why H.J.F., et al. Nitric oxide synthase activities in human myocardium. Lancet. 341:1993;84-85.
19. Yang X., Chowdury N., Cai B., et al. Induction of myocardial nitric oxide synthase by cardiac allograft rejection. J Clin Invest. 94:1994;714-721.
20. Winlaw D.S., Schyvens C.G., Smythe G.A., et al. Selective inhibition of nitric oxide production during allograft rejection causes a small increase in graft survival. Transplant. 60:1995;77-82.
21. Hare J.M., Loh E., Creager M.A., Colucci W.S. Nitric oxide inhibits the positive inotropic response to b-adrenergic stimulation in humans with left ventricular dysfunction. Circulation. 92:1995;2198-2203.
22. Mohan P., Brutsaert D.L., Paulus W.J., Sys S.U. Myocardial contractile response to nitric oxide and cGMP. Circulation. 93:1996;1223-1229.
23. Preckel B., Kojda G., Schlack W., et al. Inotropic effects of glyceryl trinitrate and spontaneous NO donors in the dog heart. Circulation. 96:1997;2675-2682.
24. Kieler-Jensen N., Ricksten S.E., Stenqvist O., et al. Inhaled nitric oxide in the evaluation of heart transplant candidates with elevated pulmonary vascular resistance. J Heart Lung Transplant. 13:(3):1994;366-375.
25. Hayward C.S., Rogers P., Keogh A.M., et al. Inhaled nitric oxide in cardiac failure: vascular versus ventricular effects. J Cardiovasc Pharmacol. 27:(1):1996;80-85.
26. Fullerton D.A., Jones S.D., Jaggers J., et al. Effective control of pulmonary vascular resistance with inhaled nitric oxide after cardiac operation. J Thorac Cardiovasc Surg. 111:(4):1996;753-763.
27. Puybasset L., Rouby J.J., Mourgeon E., et al. Inhaled nitric oxide in acute respiratory failure: dose-response curves. Intensive Care Med. 20:(5):1994;319-327.
28. Lowson S.M., Rich G.F., McArdle P.A., Jaidev J., Morris G.N. The response to varying concentrations of inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesth Analg. 82:(3):1996;574-581.
29. Gerlach H., Pappert D., Lewandowski K., Rossaint R., Falke K.J. Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory distress syndrome. Intensive Care Med. 19:(8):1993;443-449.
30. Yoshida K., Kasama K. Biotransformation of nitric oxide. Environ Health Perspect. 73:1987;201-205.
31. Young J.D., Sear J.W., Valvini E.M. Kinetics of methaemoglobin and serum nitrogen oxide production during inhalation of nitric oxide in volunteers. Br J Anaesth. 76:(5):1996;652-656.
32. Nishimura M., Hess D., Kacmarek R.M., Ritz R., Hurford W.E. Nitrogen dioxide production during mechanical ventilation with nitric oxide in adults. Effects of ventilator internal volume, air versus nitrogen dilution, minute ventilation, and inspired oxygen fraction. Anesthesiology. 82:(5):1995;1246-1254.
33. Cuthbertson B.H., Dellinger P., Dyar O.J., et al. UK guidelines for the use of inhaled nitric oxide therapy in adult ICUs American-European Consensus Conference on ALI/ARDS. Intensive Care Med. 23:(12):1997;1212-1218.
34. Mourgeon E., Levesque E., Duveau C., et al. Factors influencing indoor concentrations of nitric oxide in a Parisian intensive care unit. Am J Respir Crit Care Med. 156:(5):1997;1692-1695.
35. Ignarro L.J., Lippton H., Edwards J.C., et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther. 218:1981;739-749.
36. Stamler J.S., Simon D.I., Osborne J.A., et al. S-Nitrosylation of proteins with nitric oxide: synthesis and characterisation of biologically active compounds. Proc Natl Acad Sci USA. 89:1992;444-448.
37. Kelm M., Schrader J. Control of coronary vascular tone by nitric oxide. Circ Res. 66:1990;1561-1575.
38. Collins P., Burman J., Chung H.-I., Fox K. Hemoglobin inhibits endothelium dependent relaxation to acetylcholine in human coronary arteries in vivo. Circulation. 87:1993;80-85.
39. Deliconstantinos G., Villiotou V., Stavrides J.C. Scavenging effects of hemoglobin and related heme containing compounds on nitric oxide, reactive oxidants and carcinogenic volatile nitrosocompounds of cigarette smoke. A new method for protection against the dangerous cigarette constituents. Anticancer Res. 14:(6B):1994;2717-2726.
40. Wennmalm A., Benthin G., Edlund A., et al. Metabolism and excretion of nitric oxide in humans. An experimental and clinical study. Circ Res. 73:(6):1993;1121-1127.
41. Jacob T.D., Nakayama D.K., Seki I., et al. Hemodynamic effects and metabolic fate of inhaled nitric oxide in hypoxic piglets. J Appl Physiol. 76:(4):1994;1794-1801.
42. Gaston B., Drazen J.M., Loscalzo J., Stamler J.S. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med. 149:(2 Pt 1):1994;538-551.
43. Westfelt U.N., Benthin G., Lundin S., Stenqvist O., Wennmalm A. Conversion of inhaled nitric oxide to nitrate in man. Br J Pharmacol. 114:(8):1995;1621-1624.
44. Stamler J.S., Jaraki O., Osborne J., et al. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci USA. 89:1992;7674-7677.
45. Kowaluk E.A., Fung H.L. Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols. J Pharmacol Exp Ther. 255:1990;1256-1264.
46. Szwarc R.S., Graves C.L., Flemming F., et al. Evidence for systemic effects of inhaled nitric oxide in the anesthetised minipig. Circulation. 92:1995;I-701.
47. Shiel F.O. Morbid anatomical changes in the lungs of dogs after inhalation of higher oxides of nitrogen during anaesthesia. Br J Anaesth. 39:(5):1967;413-424.
48. Eiserich J.P., Vossen V., Ca O.N., et al. Molecular mechanisms of damage by excess nitrogen oxides: nitration of tyrosine by gas-phase cigarette smoke. FEBS Lett. 353:(1):1994;53-56.
49. Storme L., Zerimech F., Riou Y., et al. Inhaled nitric oxide neither alters oxidative stress parameters nor induces lung inflammation in premature lambs with moderate hyaline membrane disease. Biol Neonate. 73:(3):1998;172-181.
50. Rossaint R., Falke K.J., Lopez F., et al. Inhaled nitric oxide for the adult respiratory distress syndrome. New Engl J Med. 328:(6):1993;399-405.
51. Snell G.I., Salamonsen R.F., Bergin P., et al. Inhaled nitric oxide used as a bridge to heart-lung transplantation in a patient with end-stage pulmonary hypertension. Am J Respir Crit Care Med. 151:(4):1995;1263-1266.
52. Luhr O.R., Frostell C.G., Heywood R., Riley S., Lonnqvist P. Induction of chromosome aberrations in peripheral blood lymphocytes after short time inhalation of nitric oxide. Mutat Res. 414:(1-3):1998;107-115.
53. Halliwell B., Hu M.L., Louie S., et al. Interaction of nitrogen dioxide with human plasma. Antioxidant depletion and oxidative damage. FEBS Lett. 313:(1):1992;62-66.
54. Girard C., Durand P.G., Vedrinne C., et al. Case 4-1993. Inhaled nitric oxide for right ventricular failure after heart transplantation. J Cardiothorac Vasc Anesth. 7:(4):1993;481-485.
55. Young J.D., Dyar O., Xiong L., Howell S. Methaemoglobin production in normal adults inhaling low concentrations of nitric oxide. Intensive Care Med. 20:(8):1994;581-584.
56. Miller O.I., Tang S.F., Keech A., Celermajer D.S. Rebound pulmonary hypertension on withdrawal from inhaled nitric oxide. Lancet. 346:(8966):1995;51-52.
57. Atz A.M., Adatia I., Wessel D.L. Rebound pulmonary hypertension after inhalation of nitric oxide. Ann Thorac Surg. 62:(6):1996;1759-1764.
58. Cueto E., Lopez-Herce J., Sanchez A., Carrillo A. Life-threatening effects of discontinuing inhaled nitric oxide in children. Acta Paediatr. 86:(12):1997;1337-1339.
59. Oka M., Ohnishi M., Takahashi H., et al. Altered vasoreactivity in lungs isolated from rats exposed to nitric oxide gas. Am J Physiol. 271:(3 Pt 1):1996;L419-L424.
60. Buga G.M., Griscavage J.M., Rogers N.E., Ignarro L.J. Negative feedback regulation of endothelial cell function by nitric oxide. Circ Res. 73:(5):1993;808-812.
61. Roos C.M., Frank D.U., Xue C., Johns R.A., Rich G.F. Chronic inhaled nitric oxide: effects on pulmonary vascular endothelial function and pathology in rats. J Appl Physiol. 80:(1):1996;252-260.
62. Frank D.U., Horstman D.J., Morris G.N., Johns R.A., Rich G.F. Regulation of the endogenous NO pathway by prolonged inhaled NO in rats. J Appl Physiol. 85:(3):1998;1070-1078.
63. Sheehy A.M., Burson M.A., Black S.M. Nitric oxide exposure inhibits endothelial NOS activity but not gene expression: a role for superoxide. Am J Physiol. 274:(5 Pt 1):1998;L833-L841.
64. Troncy E., Collet J.P., Shapiro S., et al. Inhaled Nitric Oxide in Acute Respiratory Distress Syndrome. A pilot randomized controlled study. Am J Respir Crit Care Med. 157:(5):1997;1483-1488.
65. Michael J.R., Barton R.G., Saffle J.R., et al. Inhaled nitric oxide versus conventional therapy: effect on oxygenation in ARDS. Am J Respir Crit Care Med. 157:(5 Pt 1):1998;1372-1380.
66. Lindberg L., Larsson A., Steen S., Olsson S.G., Nordstrom L. Nitric oxide gives maximal response after coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 8:(2):1994;182-187.
67. Carmona M.J., Auler J.O. Jr. Effects of inhaled nitric oxide on respiratory system mechanics, hemodynamics, and gas exchange after cardiac surgery. J Cardiothorac Vasc Anesth. 12:(2):1998;157-161.
68. Downing S.W., Edmunds L.H. Jr. Release of vasoactive substances during cardiopulmonary bypass. Ann Thorac Surg. 54:(6):1992;1236-1243.
69. Snow D.J., Gray S.J., Ghosh S., et al. Inhaled nitric oxide in patients with normal and increased pulmonary vascular resistance after cardiac surgery. Br J Anaesth. 72:(2):1994;185-189.
70. Rich G.F., Murphy G.D. Jr., Roos C.M., Johns R.A. Inhaled nitric oxide. Selective pulmonary vasodilation in cardiac surgical patients. Anesthesiology. 78:(6):1993;1028-1035.
71. Wessel D.L., Adatia I., Giglia T.M., Thompson J.E., Kulik T.J. Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass. Circulation. 88:(5 Pt 1):1993;2128-2138.
72. Beghetti M., Silkoff P.E., Caramori M., et al. Decreased exhaled nitric oxide may be a marker of cardiopulmonary bypass-induced injury. Ann Thorac Surg. 66:(2):1998;532-534.
73. Miller O.I., Celermajer D.S., Deanfield J.E., Macrae D.J. Very-low-dose inhaled nitric oxide: a selective pulmonary vasodilator after operations for congenital heart disease. J Thorac Cardiovasc Surg. 108:(3):1994;487-494.
74. Matsui J., Yahagi N., Kumon K., et al. Effects of inhaled nitric oxide on postoperative pulmonary circulation in patients with congenital heart disease. Artif Organs. 21:(1):1997;17-20.
75. Roberts J.D. Jr., Lang P., Bigatello L.M., Vlahakes G.J., Zapol W.M. Inhaled nitric oxide in congenital heart disease. Circulation. 87:(2):1993;447-453.
76. Journois D., Pouard P., Mauriat P., et al. Inhaled nitric oxide as a therapy for pulmonary hypertension after operations for congenital heart defects. J Thorac Cardiovasc Surg. 107:(4):1994;1129-1135.
77. Girard C., Lehot J.J., Pannetier J.C., et al. Inhaled nitric oxide after mitral valve replacement in patients with chronic pulmonary artery hypertension. Anesthesiology. 77:(5):1992;880-883.
78. Fullerton D.A., Jaggers J., Wollmering M.M., et al. Variable response to inhaled nitric oxide after cardiac surgery. Ann Thorac Surg. 63:(5):1997;1251-1256.
79. Adatia I., Perry S., Landzberg M., et al. Inhaled nitric oxide and hemodynamic evaluation of patients with pulmonary hypertension before transplantation. J Am Coll Cardiol. 25:(7):1995;1656-1664.
80. Williamson D.J., Hayward C., Rogers P., et al. Acute hemodynamic responses to inhaled nitric oxide in patients with limited scleroderma and isolated pulmonary hypertension. Circulation. 94:(3):1996;477-482.
81. Foubert L., Latimer R., Oduro A., et al. Use of inhaled nitric oxide to reduce pulmonary hypertension after heart transplantation. J Cardiothorac Vasc Anesth. 7:(5):1993;640-641.
82. Auler Jr J.O., Carmona M.J., Bocchi E.A., et al. Low doses of inhaled nitric oxide in heart transplant recipients. J Heart Lung Transplant. 15:(5):1996;443-450.
83. Kieler-Jensen N., Lundin S., Ricksten S.E. Vasodilator therapy after heart transplantation: effects of inhaled nitric oxide and intravenous prostacyclin, prostaglandin E1, and sodium nitroprusside. J Heart Lung Transplant. 14:(3):1995;436-443.
84. Frazier O.H., Rose E.A., Macmanus Q., et al. Multicenter clinical evaluation of the HeartMate 1000 IP left ventricular assist device. Ann Thorac Surg. 53:(6):1992;1080-1090.
85. Yahagi N., Kumon K., Nakatani T., et al. Inhaled nitric oxide for the management of acute right ventricular failure in patients with a left ventricular assist system. Artif Organs. 19:(6):1995;557-558.
86. Macdonald P.S., Keogh A., Mundy J., et al. Adjunctive use of inhaled nitric oxide during implantation of a left ventricular assist device. J Heart Lung Transplant. 17:(3):1998;312-3136.
87. Chang J.C., Sawa Y., Ohtake S., et al. Hemodynamic effect of inhaled nitric oxide in dilated cardiomyopathy patients on LVAD support. Asaio J. 43:(5):1997;M418-M421.
88. Argenziano M., Choudhri A.F., Moazami N., et al. Randomized, double-blind trial of inhaled nitric oxide in LVAD recipients with pulmonary hypertension. Ann Thorac Surg. 65:(2):1998;340-345.
89. Kirklin J.K., Naftel D.C., Kirklin J.W., et al. Pulmonary vascular resistance and the risk of heart transplantation. J Heart Transplant. 7:(5):1988;331-336.
90. Bocchi E.A., Bacal F., Auler Junior J.O., et al. Inhaled nitric oxide leading to pulmonary edema in stable severe heart failure. Am J Cardiol. 74:(1):1994;70-72.
91. Loh E., Stamler J.S., Hare J.M., Loscalzo J., Colucci W.S. Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. Circulation. 90:1994;2780-2785.
92. Semigran M.J., Cockrill B.A., Kacmarek R., et al. Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol. 24:(4):1994;982-988.
93. Hayward C.S., Kalnins W.V., Rogers P., et al. Ventricular effects of inhaled nitric oxide in patients with impaired ventricular function. Circulation. 94:1996;I-548.
94. Hayward C.S., Kalnins W.V., Rogers P., et al. Effect of inhaled nitric oxide on normal human left ventricular function. J Am Coll Cardiol. 30:(1):1997;49-56.
95. Goldstein D.J., Dean D.A., Smerling A., et al. Inhaled nitric oxide is not a negative inotropic agent in a porcine model of pulmonary hypertension. J Thorac Cardiovasc Surg. 114:(3):1997;461-466.
96. Argenziano M., Dean D.A., Moazami N., et al. Inhaled nitric oxide is not a myocardial depressant in a porcine model of heart failure. J Thorac Cardiovasc Surg. 115:(3):1998;700-708.
97. Dickstein M.L., Burkhoff D. A theoretic analysis of the effect of pulmonary vasodilation on pulmonary venous pressure: implications for inhaled nitric oxide therapy. J Heart Lung Transplant. 15:(7):1996;715-721.
98. Hare J.M., Shernan S.K., Body S.C., et al. Influence of inhaled nitric oxide on systemic flow and ventricular filling pressure in patients receiving mechanical circulatory assistance. Circulation. 95:(9):1997;2250-2253.
99. Beghetti M., Berner M., Rimensberger P.C. Inhaled nitric oxide can cause severe systemic hypotension. J Pediatr. 130:(5):1997;844.
100. Girard C., Fargnoli J.M., Godin-Ribuot D., et al. Inhaled nitric oxide: effects on hemodynamics, myocardial contractility, and regional blood flow in dogs with mechanically induced pulmonary artery hypertension. J Heart Lung Transplant. 15:(7):1996;700-708.
101. Sitbon O., Humbert M., Jagot J.L., et al. Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension [In Process Citation]. Eur Respir J. 12:(2):1998;265-270.
102. Ricciardi M.J., Knight B.P., Martinez F.J., Rubenfire M. Inhaled nitric oxide in primary pulmonary hypertension: a safe and effective agent for predicting response to nifedipine. J Am Coll Cardiol. 32:(4):1998;1068-1073.
103. Sitbon O., Brenot F., Denjean A., et al. Inhaled nitric oxide as a screening vasodilator agent in primary pulmonary hypertension. A dose-response study and comparison with prostacyclin. Am J Respir Crit Care Med. 151:(2 Pt 1):1995;384-389.
104. Parsons S., Celermajer D., Savidis E., Miller O., Young I. The effect of inhaled nitric oxide on 6-minute walk distance in patients with pulmonary hypertension. Chest. 114:(1 Suppl):1998;70S-72S.
105. Cheifetz I.M., Craig D.M., Kern F.H., et al. Nitric oxide improves transpulmonary vascular mechanics but does not change intrinsic right ventricular contractility in an acute respiratory distress syndrome model with permissive hypercapnia. Crit Care Med. 24:(9):1996;1554-1561.
106. Hillman N.D., Cheifetz I.M., Craig D.M., et al. Inhaled nitric oxide, right ventricular efficiency, and pulmonary vascular mechanics: selective vasodilation of small pulmonary vessels during hypoxic pulmonary vasoconstriction. J Thorac Cardiovasc Surg. 113:(6):1997;1006-1013.
107. Chen E.P., Bittner H.B., Davis R.D., VanTrigt P. Hemodynamic and inotropic effects of nitric oxide in pulmonary hypertension. J Surg Res. 69:(2):1997;288-294.
108. Offner P.J., Ogura H., Jordan B.S., Pruitt B.A. Jr., Cioffi W.G. Effects of inhaled nitric oxide on right ventricular function in endotoxin shock. J Trauma. 39:(2):1995;179-186.
109. Koelling T.M., Kirmse M., Di Salvo T.G., et al. Inhaled nitric oxide improves exercise capacity in patients with severe heart failure and right ventricular dysfunction. Am J Cardiol. 81:(12):1998;1494-1497.
110. Matsumoto A., Momomura S., Hirata Y., et al. Inhaled nitric oxide and exercise capacity in congestive heart failure. Lancet. 349:(9057):1997;999-1000.
111. Speziale G., De Biase L., De Vincentis G., et al. Inhaled nitric oxide in patients with severe heart failure: changes in lung perfusion and ventilation detected using scintigraphy. Thorac Cardiovasc Surg. 44:(1):1996;35-39.
112. Matsumoto A., Momomura S., Sugiura S., et al. Effect of inhaled nitric oxide on gas exchange in patients with congestive heart failure. A randomized, controlled trial. Ann Intern Med. 130:(1):1999;40-44.
113. Radomski M.W., Palmer R.M., Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. 2:(8567):1987;1057-1058.
114. Hogman M., Frostell C., Arnberg H., Hedenstierna G. aG. Bleeding time prolongation and NO inhalation. Lancet. 341:(8861):1993;1664-1665.
115. Albert J., Wallen N.H., Broijersen A., Frostell C., Hjemdahl P. Effects of inhaled nitric oxide compared with aspirin on platelet function in vivo in healthy subjects. Clin Sci (Colch). 91:(2):1996;225-231.
116. George T.N., Johnson K.J., Bates J.N., Segar J.L. The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates. J Pediatr. 132:(4):1998;731-734.
117. Gries A., Bode C., Peter K., et al. Inhaled nitric oxide inhibits human platelet aggregation. P-selectin expression, and fibrinogen binding in vitro and in vivo. Circulation. 97:(15):1998;1481-1487.
118. Samama C.M., Diaby M., Fellahi J.L., et al. Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology. 83:(1):1995;56-65.
119. Gries A., Bottiger B.W., Dorsam J., et al. Inhaled nitric oxide inhibits platelet aggregation after pulmonary embolism in pigs. Anesthesiology. 86:(2):1997;387-393.
120. Joannidis M., Buratti T., Pechlaner C., Wiedermann C. Inhaled nitric oxide. Lancet. 348:(9039):1996;1448-1449.
121. Adrie C., Bloch K.D., Moreno P.R., et al. Inhaled nitric oxide increases coronary artery patency after thrombolysis. Circulation. 94:(8):1996;1919-1926.
122. Moro M.A., Darley-Usmar V.M., Goodwin D.A., et al. Paradoxical fate and biological action of peroxynitrite on human platelets. Proc Natl Acad Sci USA. 91:(14):1994;6702-6706.
123. Lee J.S., Adrie C., Jacob H.J., et al. Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. Circ Res. 78:(2):1996;337-342.
124. Nong Z., Hoylaerts M., VanPelt N., Collen D., Janssens S. Nitric oxide inhalation inhibits platelet aggregation and platelet- mediated pulmonary thrombosis in rats. Circ Res. 81:(5):1997;865-869.
125. Freedman J.E., Ting B., Hankin B., et al. Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes. Circulation. 98:(15):1998;1481-1486.
126. Niu X.F., Smith C.W., Kubes P. Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Circ Res. 74:(6):1994;1133-1140.
127. Fox-Robichaud A., Payne D., Hasan S.U., et al. Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds. J Clin Invest. 101:(11):1998;2497-2505.
128. Macdonald P., Mundy J., Rogers P., et al. Successful treatment of life-threatening acute reperfusion injury after lung transplantation with inhaled nitric oxide. J Thorac Cardiovasc Surg. 110:(3):1995;861-863.
129. Lindberg L., Kimblad P.O., Sjoberg T., Ingemansson R., Steen S. Inhaled nitric oxide reveals and attenuates endothelial dysfunction after lung transplantation. Ann Thorac Surg. 62:(6):1996;1639-1643.
130. Murakami S., Bacha E.A., Herve P. Prevention of reperfusion injury by inhaled nitric oxide in lungs harvested from non-heart-beating donors. Ann Thorac Surg. 62:(6):1996;1632-1638.
131. Brilli R.J., Krafte-Jacobs B., Smith D.J., et al. Aerosolization of novel nitric oxide donors selectively reduce pulmonary hypertension. Crit Care Med. 26:(8):1998;1390-1396.
132. al-Alaiyan S., al-Omran A., Dyer D. The use of phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide. Intensive Care Med. 22:(10):1996;1093-1095.
133. Ichinose F., Adrie C., Hurford W.E., Bloch K.D., Zapol W.M. Selective pulmonary vasodilation induced by aerosolized zaprinast. Anesthesiology. 88:(2):1998;410-416.
134. Lawson C.A., Smerling A.J., Naka Y., et al. Selective reduction of PVR by inhalation of a cGMP analogue in a porcine model of pulmonary hypertension. Am J Physiol. 268:(5 Pt 2):1995;H2056-H2062.
135. Haraldsson A., Kieler-Jensen N., Ricksten S.E. Inhaled prostacyclin for treatment of pulmonary hypertension after cardiac surgery or heart transplantation: a pharmacodynamic study. J Cardiothorac Vasc Anesth. 10:(7):1996;864-868.
136. Welte M., Zwissler B., Habazettl H., Messmer K. PGI2 aerosol versus nitric oxide for selective pulmonary vasodilation in hypoxic pulmonary vasoconstriction. Eur Surg Res. 25:(5):1993;329-340.