Alloantibody-mediated class I signal transduction in endothelial cells and smooth muscle cells: Enhancement IFN-γ and TNF-α

Journal of Immunology

Volumn 163, Issue 2, 1999, Pages 1010-1018

  Bian, Hong ^a   Reed, Elaine F ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIBODY; GAMMA INTERFERON; HLA ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ALLOGRAFT; ANTIGEN BINDING; ARTICLE; ATHEROSCLEROSIS; CELL PROLIFERATION; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ADJUVANTS, IMMUNOLOGIC; AORTA; CELL DIVISION; DRUG SYNERGISM; ENDOTHELIUM, VASCULAR; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; INTERFERON TYPE II; ISOANTIBODIES; LIGANDS; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; RECEPTORS, FIBROBLAST GROWTH FACTOR; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

EID: 0033565857     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (77)

1. Tilney, N. L., W. D. Whitley, J. R. Diamond, J. W. Kupiec-Weglinski, and D. H. Adams. 1991. Chronic rejection: an undefined conundrum. Transplantation 52:389.
2. Azuma, H., and N. L. Tilney. 1994. Chronic graft rejection. Curr. Opin. Immunol. 6:770.
3. Paul, L. C., and B. Fellstrom. 1992. Chronic vascular rejection of the heart and the kidney: have rational treatment options emerged? Transplantation 53:1169.
4. Fellstrom, B., L. Klareskog, C. H. Heldin, E. Larsson, L. Ronnstrand, L. Terracio, G. Tufveson, J. Wahlberg, and K. Rubin. 1989. Platelet-derived growth factor receptors in the kidney: upregulated expression in inflammation. Kidney Int. 36: 1099.
5. Zhao, X. M., T. K. Yeoh, W. H. Frist, D. L. Porterfield, and G. G. Miller. 1994. Induction of acidic fibroblast growth factor and full-length platelet-derived growth factor expression in human cardiac allografts: analysis by PCR, in situ hybridization, and immunohistochemistry. Circulation 90:677.
6. Zhao, X. M., W. H. Frist, T. K. Yeoh, and G. G. Miller. 1994. Modification of alternative messenger RNA splicing of fibroblast growth factor receptors in human cardiac allografts during rejection. J. Clin. Invest. 94:992.
7. Kerby, J. D., D. J. Verran, K. L. Luo, Q. Ding, Y. Tagouri, G. A. Herrera, A. G. Diethelm, and J. A. Thompson. 1996. Immunolocalization of FGF-1 and receptors in glomerular lesions associated with chronic human renal allograft rejection. Transplantation 62:190.
8. McCarthy, J. F., D. J. Cook, M. G. Massad, Y. Sano, K. J. O'Malley, N. R. Ratliff, R. W. Stewart, N. G. Smedira, R. C. Starling, J. B. Young, and P. M. McCarthy. 1998. Vascular rejection post heart transplantation is associated with positive flow cytometric cross-matching. Eur. J. Cardiothorac. Surg. 14: 197.
9. Itescu, S., T. C. Tung, E. M. Burke, A. D. Weinberg, D. Mancini, R. E. Michler, N. M. Suciu-Foca, and E. A. Rose. 1998. An immunological algorithm to predict risk of high-grade rejection in cardiac transplant recipients. Lancet 352:263.
10. Kerman, R. H., B. Susskind, D. H. Kerman, M. Lam, K. Gerolami, J. Williams, R. Kalish, M. Campbell, S. M. Katz, C. T. Van Buren, and B. D. Kahan. 1997. Anti-HLA antibodies detected in posttransplant renal allograft recipient sera correlate with chronic rejection. Transplant. Proc. 29:1515.
11. Costa, A. N., M. P. Scolari, S. Iannelli, A. Buscaroli, G. L. D'Arcangelo, B. Brando, F. Indiveri, M. Savi, L. C. Borgnino, L. B. DeSanctis, S. Stefoni, and V. Bonomini. 1997. The presence of posttransplant HLA-specific IgG antibodies detected by enzyme-linked immunosorbent assay correlates with specific rejection pathologies. Transplantation 63:167.
12. Barr, M. L., D. J. Cohen, A. I. Benvenisty, M. Hardy, K. Reemtsma, E. A. Rose, C. C. Marboe, V. D'Agati, N. Suciu-Foca, and E. Reed. 1993. Effect of anti-HLA antibodies on the long-term survival of heart and kidney allografts. Transplant. Proc. 25:262.
13. Smith, J. D., A. J. Danskine, M. L. Rose, and M. H. Yacoub. 1992. Specificity of lymphocytotoxic antibodies formed after cardiac transplantation and correlation with rejection episodes. Transplantation 53:1358.
14. Ende, N., E. V. Orsi, N. Z. Baturay, and T. L. Britten. 1979. Properties of a cytotoxic kidney antibody associated with human renal transplantation. Am. J. Clin. Pathol. 71:543.
15. Duijvestijn, A. M., and P. J. van Breda Vriesman. 1991. Chronic renal allograft rejection: selective involvement of the glomerular endothelium in humoral immune reactivity and intravascular coagulation. Transplantation 52:195.
16. Reed, E., E. Ho, D. J. Cohen, W. Ramey, C. Marboe, V. D'Agati, E. A. Rose, M. Hardy, and N. Suciu-Foca. 1993. Anti-idiotypic antibodies specific for HLA in heart and kidney allograft recipients. Immunol. Res. 12:1.
17. Suciu-Foca, N., E. Reed, C. Marboe, P. Harris, P. X. Yu, Y. K. Sun, E. Ho, E. Rose, K. Reemtsma, and D. W. King. 1991. The role of anti-HLA antibodies in heart transplantation. Transplantation 51:716.
18. Suciu-Foca, N., E. Reed, V. D. D'Agati, E. Ho, D. J. Cohen, A. I. Benvenisty, R. McCabe, J. M. Brensilver, D. W. King, and M. A. Hardy. 1991. Soluble HLA antigens, anti-HLA antibodies, and antiidiotypic antibodies in the circulation of renal transplant recipients. Transplantation 51:593.
19. Schulman, L. L., E. K. Ho. E. F. Reed, C. McGregor, C. R. Smith, E. A. Rose, and N. M. Suciu-Foca. 1996. Immunologic monitoring in lung allograft recipients. Transplantation 61:252.
20. Reed, E. F., B. Hong, E. Ho, P. E. Harris, J. Weinberger, and N. Suciu-Foca. 1996. Monitoring of soluble HLA alloantigens and anti-HLA antibodies identifies heart allograft recipients at risk of transplant-associated coronary artery disease. Transplantation 61:566.
21. Reed, E., D. J. Cohen, M. L. Barr, E. Ho, C. C. Marboe, E. A. Rose, M. Hardy, and N. Suciu-Foca. 1992. Effect of anti-HLA and anti-idiotypic antibodies on the long-term survival of heart and kidney allografts. Transplant. Proc. 24:2494.
22. Fisher, P. E., N. Suciu-Foca, E. Ho, R. E. Michler, E. A. Rose, and D. Mancini. 1995. Additive value of immunologic monitoring to histologic grading of heart allograft biopsy specimens: implications for therapy. J. Heart Lung Transplant. 14:1156.
23. Fenoglio, J., E. Ho, E. Reed, E. Rose, C. Smith, K. Reemstma, C. Marboe, and N. Suciu-Foca. 1989. Anti-HLA antibodies and heart allograft survival. Transplant. Proc. 21:807.
24. Cherry, R., H. Nielsen, E. Reed, K. Reemtsma, N. Suciu-Foca, and C. C. Marboe. 1992. Vascular (humoral) rejection in human cardiac allograft biopsies: relation to circulating anti-HLA antibodies. J. Heart Lung Transplant. 11:24.
25. Russell, P. S., C. M. Chase, H. J. Winn, and R. B. Colvin. 1994. Coronary atherosclerosis in transplanted mouse hearts. I. Time course and immunogenetic and immunopathological considerations. Am. J. Pathol. 144:260.
26. Russell, P. S., C. M. Chase, H. J. Winn, and R. B. Colvin. 1994. Coronary atherosclerosis in transplanted mouse hearts. II. Importance of humoral immunity. J. Immunol. 152:5135.
27. O'Connell, T. X., and J. F. Mowbray. 1973. Arterial intimal thickening produced by alloantibody and xenoantibody. Transplantation 15:262.
28. Shi, C., W. S. Lee, Q. He, D. Zhang, D. L. Fletcher, Jr., J. B. Newell, and E. Haber. 1996. Immunologic basis of transplant-associated arteriosclerosis. Proc. Natl. Acad. Sci. USA 93:4051.
29. Haber, E., and C. Shi. 1997. The role of specific genes in transplant arteriosclerosis: studies in mutant mice. Transplant. Immunol. 5:293.
30. Russell, P. S., C. M. Chase, and R. B. Colvin. 1997. Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis: lack of progression to sclerotic lesions in B cell-deficient mice. Transplantation 64:1531.
31. Skov, S., M. Nielsen, S. Bregenholt, N. Odum, and M. H. Claesson. 1998. Activation of Stat-3 is involved in the induction of apoptosis after ligation of major histocompatibility complex class I molecules on human Jurkat T cells. Blood 91:3566.
32. Genestier, L., A. F. Prigent, R. Paillot, L. Quemeneur, I. Durand, J. Banchereau, J. P. Revillard, and N. Bonnefoy-Berard. 1998. Caspase-dependent ceramide production in Fas- and HLA class I-mediated peripheral T cell apoptosis. J Biol. Chem. 273:5060.
33. Genestier, L., R. Paillot, N. Bonnefoy-Berard, G. Meffre, M. Flacher, D. Fevre, Y. J. Liu, P. Le Bouteiller, H. Waldmann, V. H. Engelhard, J. Banchereau, and J. P. Revillard. 1997. Fas-independent apoptosis of activated T cells induced by antibodies to the HLA class I α1 domain. Blood 90:3629.
34. Woodle, E. S., D. M. Smith, J. A. Bluestone, W. M. Kirkman, 3rd, D. R. Green, and E. W. Skowronski. 1997. Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway. J. Immunol. 158:2156.
35. Gilliland, L. K., N. A. Norris, L. S. Grosmaire, S. Ferrone, P. Gladstone, and J. A. Ledbetter. 1989. Signal transduction in lymphocyte activation through crosslinking of HLA class I molecules. Hum. Immunol. 25:269.
36. Wacholtz, M. C., S. S. Patel, and P. E. Lipsky. 1989. Patterns of costimulation of T cell clones by cross-linking CD3, CD4/CD8, and class I MHC molecules. J Immunol. 142:4201.
37. Geppert, T. D., M. C. Wacholtz, S. S. Patel, E. Lightfoot, and P. E. Lipsky. 1989. Activation of human T cell clones and Jurkat cells by cross-linking class I MHC molecules. J. Immunol. 142:3763.
38. Dissing, S., C. Geisler, B. Rubin, T. Plesner, and M. H. Claesson. 1990. T cell activation. II. Activation of human T lymphoma cells by cross-linking of their MHC class I antigens. Cell. Immunol. 126:196.
39. Geppert, T. D., H. Nguyen, and P. E. Lipsky. 1992. Engagement of class I major histocompatibility complex molecules by cell surface CD8 delivers an activation signal. Eur. J. Immunol. 22:1379.
40. Reed, E., M. Hardy, A. Benvenisty, C. Lattes, J. Brensilver, R. McCabe, K. Reemstma, D. W. King, and N. Suciu-Foca. 1987. Effect of antiidiotypic antibodies to HLA on graft survival in renal-allograft recipients. N. Engl. J. Med. 316:1450.
41. Reed, E., V. Bonagura, P. Kung, D. W. King, and N. Suciu-Foca. 1983. Anti-idiotypic antibodies to HLA-DR4 and DR2. J. Immunol. 131:2890.
42. Bian, H., P. E. Harris, and E. F. Reed. 1998. Ligation of HLA class I molecules on smooth muscle cells with anti-HLA antibodies induces tyrosine phosphorylation, fibroblast growth factor receptor expression and cell proliferation. Int. Immunol. 10:1315.
43. Bian, H., P. E. Harris, A. Mulder, and E. F. Reed. 1997. Anti-HLA antibody ligation to HLA class I molecules expressed by endothelial cells stimulates tyrosine phosphorylation, inositol phosphate generation, and proliferation. Hum. Immunol. 53:90.
44. Smith, J. D., M. H. Yacoub, and M. L. Rose. 1998. Endothelial cell activation by sera containing HLA antibodies is mediated by interleukin-1. Transplantation 66:1229.
45. Nickerson, P., J. Steiger, X. X. Zheng, A. W. Steele, W. Steurer, P. Roy-Chaudhury, and T. B. Strom. 1997. Manipulation of cytokine networks in transplantation: false hope or realistic opportunity for tolerance? Transplantation 63:489.
46. Salom, R. N., J. A. Maguire, and W. W. Hancock. 1998. Endothelial activation and cytokine expression in human acute cardiac allograft rejection. Pathology 30:24.
47. Flach, R., N. Speidel, S. Flohe, J. Borgermann, I. G. Dresen, J. Erhard, and F. U. Schade. 1998. Analysis of intragraft cytokine expression during early reperfusion after liver transplantation using semi-quantitative RT-PCR. Cytokine 10: 445.
48. Josien, R., M. Muschen, E. Gilbert, P. Douillard, J. M. Heslan, J. P. Soulillou, and M. C. Cuturi. 1998. Fas ligand, tumor necrosis factor-α expression, and apoptosis during allograft rejection and tolerance. Transplantation 66:887.
49. Horie, Y., R. P. Chervenak, R. Wolf, M. E. Gerritsen, D. C. Anderson, S. Komatsu, and D. N. Granger. 1997. Lymphocytes mediate TNF-α-induced endothelial cell adhesion molecule expression: studies on SCID and RAG-1 mutant mice. J. Immunol. 159:5053.
50. Sterpetti, A. V., A. Cucina, S. Lepidi, B. Randone, V. Corvino, L. S. D'Angelo, and A. Cavallaro. 1998. Formation of myointimal hyperplasia and cytokine production in experimental vein grafts. Surgery 123:461.
51. Stricter, R. M., S. L. Kunkel, and R. C. Bone. 1993. Role of tumor necrosis factor-α in disease states and inflammation. Crit. Care Med. 21:S447.
52. Gobin, S. J., A. Peijnenburg, V. Keijsers, and P. J. van den Elsen. 1997. Site α is crucial for two routes of IFN γ-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA. Immunity 6:601.
53. Gur, H., M. C. Wacholtz, W. R. Lie, P. E. Lipsky, and T. D. Geppert. 1992. Comparison of the capacity of murine and human class I MHC molecules to stimulate T cell activation. Cell. Immunol. 144:392.
54. Gur, H., F. el-Zaatari, T. D. Geppert, M. C. Wacholtz, J. D. Taurog, and P. E. Lipsky. 1990. Analysis of T cell signaling by class I MHC molecules: the cytoplasmic domain is not required for signal transduction. J. Exp. Med. 172: 1267.
55. Wagner, N., P. Engel, M. Vega, and T. F. Tedder. 1994. Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes. J Immunol. 152:5275.
56. Hansen, N. Q., T. Tscherning, and M. H. Claesson. 1991. T-cell activation. IV. Evidence for a functional linkage between MHC class I, interleukin-2 receptor, and interleukin-4 receptor molecules. Cytokine 3:35.
57. Tscherning, T., and M. H. Claesson. 1994. Signal transduction via MHC class-I molecules in T cells [editorial]. Scand. J. Immunol. 39:117.
58. Claesson, M. H., B. Endel, J. Ulrik, L. O. Pedersen, S. Skov, and S. Buus. 1994. Antibodies directed against monomorphic and evolutionary conserved self epitopes may be generated in "knock-out" mice: development of monoclonal antibodies directed against monomorphic MHC class I determinants. Scand. J. Immunol. 40:257.
59. Skov, S., N. Odum, and M. H. Claesson. 1995. MHC class I signaling in T cells leads to tyrosine kinase activity and PLC-γI phosphorylation. J. Immunol. 154: 1167.
60. Bregenholt, S., M. Ropke, S. Skov, and M. H. Claesson. 1996. Ligation of MHC class I molecules on peripheral blood T lymphocytes induces new phenotypes and functions. J. Immunol. 157:993.
61. Nissen, M. H., S. Bregenholt, J. A. Nording, and M. H. Claesson. 1998. Cl-esterase inhibitor blocks T lymphocyte proliferation and cytotoxic T lymphocyte generation in vitro. Int. Immunol. 10:167.
62. lck tyrosine kinases, leads to an alternative phenotype of the TCR/CD3 ζ-chain, and induces apoptosis. J. Immunol. 158:3189.
63. Pedersen, A. E., B. F. Jacoby, S. Skov, and M. H. Claesson. 1996. MHC class I is functionally associated with antigen receptors in human T and B lymphomas. Cell. Immunol. 173:295.
64. Dasgupta, J. D., E. Egea, V. Relias, A. Iglesias, P. Gladstone, and E. J. Yunis. 1990. Involvement of major histocompatibility complex class I antigens in T cell activation. Eur. J. Immunol. 20:1553.
65. Geppert, T. D., M. C. Wacholtz, L. S. Davis, and P. E. Lipsky. 1988. Activation of human T4 cells by cross-linking class I MHC molecules. J. Immunol. 140: 2155.
66. De Felice, M., M. C. Turco, F. Costanzo, L. Corbo, S. Ferrone, and S. Venuta. 1990. Inhibition by anti-HLA class I mAb of IL-2 and IL-2 receptor synthesis in lymphocytes stimulated with PHA-P. Cell. Immunol. 126:420.
67. Taylor, D. S., P. C. Nowell, and J. Kornbluth. 1986. Functional role of HLA class I cell-surface molecules in human T-lymphocyte activation and proliferation. Proc. Natl. Acad. Sci. USA 83:4446.
68. Taylor, D. S., P. C. Nowell, and J. Kornbluth. 1987. Anti-HLA class I antibodies inhibit the T cell-independent proliferation of human B lymphocytes. J. Immunol. 139:1792.
69. Harris, P. E., H. Bian, and E. F. Reed. 1997. Induction of high affinity fibroblast growth factor receptor expression and proliferation in human endothelial cells by anti-HLA antibodies: a possible mechanism for transplant atherosclerosis. J. Immunol. 159:5697.
70. Strom, T. B., P. Roy-Chaudhury, R. Manfro, X. X. Zheng, P. W. Nickerson, K. Wood, and A. Bushell. 1996. The Th1/Th2 paradigm and the allograft response. Curr. Opin. Immunol. 8:688.
71. Shi, E., M. Kan, J. Xu, F. Wang, J. Hou, and W. L. McKeehan. 1993. Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants. Mol. Cell. Biol. 13:3907.
72. Wang, F., M. Kan, G. Van, J. Xu, and W. L. McKeehan. 1995. Alternately spliced NH2-terminal immunoglobulin-like Loop I in the ectodomain of the fibroblast growth factor (FGF) receptor 1 lowers affinity for both heparin and FGF-1. J. Biol. Chem. 270:10231.
73. Mohammadi, M., C. A. Dionne, W. Li, N. Li, T. Spivak, A. M. Honegger, M. Jaye, and J. Schlessinger. 1992. Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature 358:681.
74. Kouhara, H., Y. R. Hadari, T. Spivak-Kroizman, J. Schilling, D. Bar-Sagi, I. Lax, and J. Schlessinger. 1997. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 89:693.
75. Huang, J., M. Mohammadi, G. A. Rodrigues, and J. Schlessinger. 1995. Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis. J. Biol. Chem. 270:5065.
76. Nath, N., H. Bian, E. F. Reed, and S. P. Chellappan. 1999. HLA class I-mediated induction of cell proliferation involves cyclin E-mediated inactivation of Rb function and induction of E2F activity. J. Immunol. 162:5351.
77. Mohammadi, M., I. Dikic, A. Sorokin, W. H. Burgess, M. Jaye, and J. Schlessinger. 1996. Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol. Cell. Biol. 16:977.