C1-esterase inhibitor blocks T lymphocyte proliferation and cytotoxic T lymphocyte generation in vitro

International Immunology

Volumn 10, Issue 2, 1998, Pages 167-173

  Nissen, Mogens Holst ^a   Bregenholt, Søren ^a   Nording, Jens A ^a   Claesson, Mogens H ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

2 microglobulin; Alloreactivity; C1 esterase inhibitor; Complement; MHC class I

Indexed keywords

BETA 2 MICROGLOBULIN; COMPLEMENT COMPONENT C1S INHIBITOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL CELL; ARTICLE; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MIXED LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; CELLS, CULTURED; COMPLEMENT C1 INACTIVATOR PROTEINS; COMPLEMENT C1S; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROTEASE INHIBITORS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0031908584     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.2.167     Document Type: Article

References (40)

1. Nissen, M. H., Roepstorff, P., Thim, L., Dunbar, B. and Fothergill, J. E. 1990. Limited proteolysis of beta 2-microglobulin at Lys-58 by complement component C1s. Eur. J. Biochem. 189:423.
2. Nissen, M. H., Thim, L. and Christensen, M. 1987. Purification and biochemical characterization of the complete structure of a proteolytically modified beta-2-microglobulin with biological activity. Eur. J. Biochem. 163:21.
3. Nissen, M. H. and Claesson, M. H. 1987. Proteolytically modified human beta 2-microglobulin augments the specific cytotoxic activity in murine mixed lymphocyte culture. J. Immunol. 139:1022.
4. Cooper, N. R. 1985. The classical complement pathway: activation and regulation of the first complement component. Adv. Immunol. 37:151.
5. Sim, R. B., Reboul, A., Chang, N. S., Boackle, R. J. and Leu, R. W. 1981. Preparation and properties of human C1 inhibitor. Characterization of C1 inhibitor binding to neutrophils. Methods Enzymol. 80:43.
6. Chang, N. S., Boackle, R. J. and Leu, R. W. 1991. Characterization of C1 inhibitor binding to neutrophils. Immunology 73:95.
7. Osther, K., Hojgaard, K. and Dybkjaer, E. 1974. Demonstration of a complement of inactivator on cultured cells from human malignant brain tumours. Acta Neurolog. Scand. 50:681.
8. Osther, K. and Linnemann, R. 1973. Immunofluorescence measurement of C1 inactivator (alpha 2 neuraminoglycoprotein) activity of the surface of human carcinoma cells. Acta Patholog. Microbiolog. Scand. B 81:365.
9. Osther, K., Linnemann, R., Hojgaard, K. and Dybkjaer, E. 1973. Measurement of C1 inactivator (alpha 2 neuraminoglycoprotein) on human blast cells in blast leukaemia. Demonstration of a complement of inactivator on cultured cells from human malignant brain tumours. Acta Patholog. Microbiolog. Scand. B 81:271.
10. Cole, F. S. and Cooper, N. R. 1987. Complement biosynthesis. In Rother, K. and Till, G. O., eds. The Complement System, p. 44. Springer, New York.
11. Harrison, R. A. 1983. Human C1 inhibitor: improved isolation and preliminary structural characterization. Biochemistry 22:5001.
12. Davis, A. E., Aulak, K. S. Zahedi, K. Bissler, J. J. and Harrison, R. A. 1993. C1 inhibitor. Methods Enzymol. 223:97.
13. van den Berg CW, Aerts, P. C. and van Dijk, D. H. 1992. C1-inhibitor prevents PEG fractionation-induced, EDTA-resistant activation of mouse complement. Mol. Immunol. 29:363.
14. Kam, C. M., Oglesby, T. J., Pangburn, M. K., Volanakis, J. E. and Powers, J. C. 1992. Substituted isocoumarins as inhibitors of complement serine proteases. J. Immunol. 149:163.
15. Levy, L. R. and Lepow, I. H. 1959. Assay and properties of serum inhibitor of C1-esterase. Proc. Soc. Exp. Biol. 608.
16. Donaldson, V. H. and Pensky, J. 1970. Some observations on the phylogeny of serum inhibitor of C1 esterase. J. Immunol. 104:1388.
17. Gigli, I. and Austen, K. F. 1971. Phylogeny and function of the complement system. Annu. Rev. Microbiol. 25:309.
18. Gulati, P., Lemercier, C., Guc, D., Lappin, D. and Whaley, K. 1993. Regulation of the synthesis of C1 subcomponents and C1-inhibitor. Behring Inst. Mitteil. 196.
19. Lappin, D. and Whaley, K. 1989. Regulation of C1-inhibitor synthesis by interferons and other agents. Behring Inst. Mitteil. 180.
20. Lappin, D. F., Guc, D., Hill, A., McShane, T. and Whaley, K. 1992. Effect of interferon-gamma on complement gene expression in different cell types. Biochem. J. 281:437.
21. Lotz, M. and Zuraw, B. L. 1987. Interferon-gamma is a major regulator of C1-inhibitor synthesis by human blood monocytes. J. Immunol. 139:3382.
22. Bjerrum, O. W., Nissen, M. H. and Borregaard, N. 1990. Neutrophil beta-2 microglobulin: an inflammatory mediator. Scand. J. Immunol. 32:233.
23. Yap, S. H., Moshage, H. J., Hazenberg, B. P., Roelofs, H. M., Bijzet, J., Limburg, P. C., Aarden, L. A. and van Rijswijk, R. M. 1991. Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and/ or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes. Biochim. Biophys. Acta 1091:405.
24. Majello, B., Arcone, R., Toniatti, C. and Ciliberto, G. 1990. Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. EMBO J. 9:457.
25. Kuta, A. E. and Baum, L. L. 1986. C-reactive protein is produced by a small number of normal human peripheral blood lymphocytes. J. Exp. Med. 164:321.
26. Jiang, H. X., Siegel, J. N. and Gewurz, H. 1991. Binding and complement activation by C-reactive protein via the collagen-like region of C1q and inhibition of these reactions by monoclonal antibodies to C-reactive protein and C1q. J. Immunol. 146:2324.
27. Berman, S., Gewurz, H. and Mold, C. 1986. Binding of C-reactive protein to nucleated cells leads to complement activation without cytolysis. J. Immunol. 136:1354.
28. Tscherning, T. and Claesson, M. H. 1994. Signal transduction via MHC class-I molecules in T cells [Editorial]. Scand. J. Immunol. 39:117.
29. Pedersen, A. E., Jacoby, B. F., Skov, S. and Claesson, M. H. 1996. MHC class I is functionally associated with antigen receptors in human T and B lymphomas. Cell. Immunol. 173:295.
30. Bregenholt, S., Ropke, M., Skov, S. and M. H. Claesson, 1996. Ligation of MHC class I molecules on peripheral blood T lymphocytes induces new phenotypes and functions. J. Immunol. 157:993.
31. lck tyrosine kinases, leads to an alternative phenotype of the TCR/CD3 zeta-chain, and induces apoptosis. J. Immunol. 158:3189.
32. Skov, S., Odum, N. and Claesson, M. H. 1995. MHC class I signaling in T cells leads to tyrosine kinase activity and PLC-gamma 1 phosphorylation. J. Immunol. 154:1167.
33. Geppert, T. D., Nguyen, H. and Lipsky, P. E. 1992. Engagement of class I major histocompatibility complex molecules by cell surface CDS delivers an activation signal. Eur. J. Immunol. 22:1379.
34. Geppert, T. D., Wacholtz, M. C., Davis, L. S. and Lipsky, P. E. 1988. Activation of human T4 cells by cross-linking class I MHC molecules. J. Immunol. 140:2155.
35. Geppert, T. D., Wacholtz, M. C., Patel, S. S. Lightfoot, E. and Lipsky, P. E. 1989. Activation of human T cell clones and Jurkat cells by cross-linking class I MHC molecules. J. Immunol. 142:3763.
36. Gur, H., Wacholtz, M. C., Lie, W. R., Lipsky, P. E. and Geppert, T. D. 1992. Comparison of the capacity of murine and human class I MHC molecules to stimulate T cell activation. Cell. Immunol. 144:392.
37. Steve Woodle, E., Smith, D. N., Bluestone, J. A., Kirkmann III, W. M., Green, D. R., and Skowronski, E. V. 1997. Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway. J. Immunol. 158:2156.
38. Shen, N. L., Fan, S. T., Pyati, J., Graft, R., LaPolla, R. J. and Edgington, T. S. 1993. The serine protease cofactor factor V is synthesized by lymphocytes. J. Immunol. 150:2992.
39. Aoki, Y., Hase, T., Oshimi, K. and Suzuki, K. 1992. Induction of activated killer cells from human lymphocytes by medullasin (a serine protease in bone marrow cells). Immunology 75:481.
40. Gregorek, H., Kokai, M., Hidvegi, T., Fust, G., Sabbouh, K. and Madalinski, K. 1991. Concentration of C1 inhibitor in sera of healthy blood donors as studied by immunoenzymatic assay. Complement & Inflammation 8:310.