TCR and IL-12 receptor signals cooperate to activate an individual response element in the IFN-γ promoter in effector Th cells

Journal of Immunology

Volumn 163, Issue 2, 1999, Pages 728-735

  Zhang, Feng ^a   Nakamura, Tetsuo ^b   Aune, Thomas M ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 12 RECEPTOR; LUCIFERASE;

ANIMAL CELL; ARTICLE; DNA PROTEIN COMPLEX; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD3; CELLS, CULTURED; IMMUNE SERA; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; MITOGENS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0033565581     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Boehm, U., T. Klamp, M. Groot, and J. Howard. 1997. Cellular responses to interferon. Annu. Rev. Immunol. 15:749.
2. Billiau, A. 1996. Interferon. Adv. Immunol. 62:61.
3. Trinchieri, G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008.
4. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
5. Scott, P. 1993. IL-12: initiation cytokine for cell-mediated immunity. Science 260:496.
6. Seder, R. A., and W. E. Paul. 1994. Acquisition of lymphokine-producing phenotype by CD4 T cells. Annu. Rev. Immunol. 12:635.
7. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
8. Okamura, H., H. Tsutsui, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, et al. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88.
9. + T lymphocytes. J. Immunol. 160:3642.
10. Robinson, D., K. Shibuya, A. Mui, F. Zonin, E. Murphy, T. Sana, S. B. Hartley, S. Menon, R. Kastelein, F. Bazan, and A. Ogarra. 1997. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NF-κB. Immunity 7:571.
11. Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, Jr., and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181:1755.
12. Chan, S. J., B. Perussia, J. W. Gupta, M. Kobayashi, M. Posisil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of interferon-γ production by natural killer stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869.
13. Murphy, E. E., G. Terres, S. E. Macatonia, C. -S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. M. Murphy, and A. O'Garra. 1994. B7 and interleukin 12 cooperate for proliferation and interferon-γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223.
14. Kubin, M., M. Kamoun, and G. Trinchieri. 1994. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180:211.
15. Penix, L., W. M. Weaver, Y. Pang, H. A. Young, and C. B. Wilson. 1993. Two essential regulatory elements in the human Interferon γ promoter confer activation specific expression in T cells. J. Exp. Med. 178:1483.
16. Cippitelli, M., A. Sica, V. Viggiano, J. Ye, P. Ghosh, M. J. Birrer, and H. A. Young. 1995. Negative transcriptional regulation of the interferon-γ (IFNγ) promoter by glucocorticoids and dominant-negative mutants of c-Jun. J. Biol. Chem. 270:12548.
17. Aune, T. M., L. A. Penix, M. R. Rincon, and R. A. Ravell. 1996. Differential transcription directed by discrete IFNγ promoter elements in naive and memory (effector) CD4 T cells, and CD8 T cells. Mol. Cell. Biol. 17:199.
18. Penix, L. A., M. T. Sweetser, W. M. Weaver, J. P. Hoeffler, T. K. Kerppola, and C .B. Wilson. 1996. The proximal regulatory element of the interferon-γ promoter mediates selective expression in T cells. J. Biol. Chem. 271:31964.
19. Zhang, F., D. Z. Wang, M. Boothby, L. Penix, R. A. Flavell, and T. M. Aune. 1998. Regulation of the activity of IFN-γ promoter elements during Th cell differentiation. J. Immunol. 161:6105.
20. Ye, J., P. Ghosh, M. Cippitelli, J. Subleski, K. J. Hardy, J. R. Ortaldo, and H. A. Young. 1994. Characterization of a silencer regulatory element in the human interferon-γ promoter J. Biol. Chem. 269:25728.
21. Ye, J., M. Cippitelli, L. Dorman, J. R. Ortaldo, and H. A. Young. 1996. The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhbition of AP1 binding and activation of a silencer element. Mol. Cel. Biol. 16:4744.
22. Sica, A., L. Dorman, V. Viggiano, M. Cippitelli, P. Ghosh, N. Rice, and H. A. Young. 1997. Interaction of NF-κB and NFAT with the interferon-γ promoter. J. Biol. Chem. 272:30412.
23. Xu, X., Y.-L. Sun, and T. Hoey. 1996. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 273:794.
24. Sweetser, M. T., T. Hoey, Y. -L. Sun, W. M. Weaver, G. A. Price, and C. B. Wilson. 1998. The roles of nuclear factor of activated T cells and Ying-Yang I in activation-induced expression of the interferon-y promoter in T cells. J. Biol. Chem. 273:34775.
25. De Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinska, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725.
26. Hogan, B., F. Costantini, and E. Lacy. 1986. Manipulating the Mouse Embryo, A Laboratory Manual. Cold Spring Harbor Laboratory Press, Plainview.
27. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341:746.
28. Thierfelder, W. E., J. M. van Deursen, K. Yamamoto, R. A. Tripp, S. R. Sarawar, R. R. Carson, M. Y. Sangster, D. A. A. Vignali, P. C. Doeherty, G. C. Grosveld, and J. N. Ihle. 1996. Requirement for Stat4 in interleukin-12 mediated responses of natural killer and T cells. Nature 382:171.
29. Schreiber, E., P. Mathias, M. Muller, and W. Sheffner. 1989. Rapid detection of octamer binding proteins with mini-extracts prepared from small numbers of cells. Nucleic Acids Res. 17:6419.
30. Tugures, A., M. A. Alonso, F. Sanchez-Madrid, and M. O. De Landazuri. 1992. Human T cell activation through the activation inducer molecule CD69 enhances the activity of transcription factor AP-1. J. Immunol. 148:2300.
31. Kaplan, M. K., Y. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174.
32. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727.
33. Karin, M., Z. -G. Liu, and E. Zandi. AP-I function and regulation. Curr. Opin. Cell Biol. 9:240.
34. Angel, P., and M. Karin. 1991. The role of jun, fos and the AP-1 complex in cell proliferation and transformation. Biochim. Biophys. Acta 107:129.
35. McBride, K., and M. Nemer. 1998. The C-terminal domain of c-fos is required for activation of an AP-1 site specific for jun-fos heterodimers. Mol. Cell. Biol. 18:5073.
36. Deng, T., and M. Karin. 1993. JunB differs from c-Jun in its DNA-binding and dimerization domains and represses c-Jun by formation of inactive heterodimers. Genes Dev. 7:479.
37. Lucibello, F.C., E. P. Slater, K. U. Jooss, M. Beato, and R. Muller. 1990. Mutual transrepression of fos and the glucocorticoid receptor: involvement of a functional domain in fos which is absent in fosb. EMBO J. 9:2827.
38. Suzuki, T., H. Okuno, T. Yoshida, T. Endo, H. Nishinal and H. Iba. 1991. Difference in transcriptional regulatory function between c-Fos and Fra-2. Nucleic Acids Res. 19:5537.
39. Claret, F. -X., M. Hibi, S. Dhut, T. Toda, and M. Karin. 1996. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature 383:453.