Human thymocytes express CCR-3 and are activated by eotaxin

Blood

Volumn 93, Issue 10, 1999, Pages 3233-3240

  Franz Bacon, Karin ^a   Dairaghi, Daniel J ^b   Boehme, Stefen A ^b   Sullivan, Susan K ^b   Schall, Thomas J ^b   Conlon, Paul J ^b   Taylor, Naomi ^b   Bacon, Kevin B ^b  

^a NEUROCRINE BIOSCIENCES INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR3; EOTAXIN; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; LEUKOCYTE MIGRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; RECEPTOR BINDING; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS; TISSUE DISTRIBUTION;

EID: 0033562346     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.10.3233.410k33_3233_3240     Document Type: Article

References (33)

1. Griffiths-Johnson DA, Collins PD, Rossi AG, Jose PJ, Williams TJ: The chemokine eotaxin activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo. Biochem Biophys Res Commun 197:1167, 1993
2. Jose PJ, Griffiths JD, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ: Eotaxin: A potent eosinophil chemoattractant cytokine detected in a guinea-pig model of allergic airways inflammation. J Exp Med 179:881, 1994
3. Jose PJ, Adcock IM, Grifiths-Johnson DA, Berkman N, Wells TN, Williams TJ, Power CA: Eotaxin: Cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergenchallenged guinea-pig lungs. Biochem Biophys Res Commun 205:788, 1994
4. Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo J-A, Newman W, Gutierrez-Ramos J-C, Mackay CR: Cloning of the human eosinophil chemoattractant eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest 97:604, 1996
5. Ying S, Robinson DS, Meng Q, Rottman J, Kennedy R, Ringler DJ, Mackay CR, Daugherty BL, Springer MS, Durham SR, Williams TJ, Kay AB: Enhanced expression of eotaxin and CCR-3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol 27:3507, 1997
6. Lamkhioued B, Renzi PM, Abi-Younes S, Garcia-Zepada EA, Allakhverdi Z, Ghaffar O, Rothenberg MD, Luster AD, Hamid Q: Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation. J Immunol 159:4593, 1997
7. Rothenberg ME, Luster AD, Lilly CM, Drazen JM, Leder P: Constitutive and allergen-induced expression of eotaxin mRNA in the guinea-pig lung. J Exp Med 181:1211, 1995
8. Rothenberg ME, Luster AD, Leder P: Murine eotaxin: An eosinophil chemoattractant inducible in endothelial cells and in IL-4-induced tumor supression. Proc Natl Acad Sci USA 92:8960, 1995
9. Gonzalo J-A, Jia G-Q, Aguirre V, Coyle A, Jenkins N, Katz H, Lichtman A, Copeland N, Kopf M, Gutierrez-Ramos JC: Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammatory reactions but is not restricted to a Th2-type response. Immunity 4:1, 1996
10. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD: Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med 2:449, 1996
11. Collins PD, Marleau S, Griffiths-Johnson DA, Jose PJ, Williams TJ: Cooperation betweem interleukin 5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med 182:1169, 1995
12. Daugherty BL, Siciliano SJ, De Martino JA, Malkowitz L, Sirotina A, Springer MS: Cloning, expression and characterization of the human eosinophil eotaxin receptor. J Exp Med 183:2349, 1996
13. Ponath PD, Qin S, Post TW, Wang J. Wu L, Gerard NP, Newman W, Gerard C, Mackay CR: Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med 183:2437, 1996
14. Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O: Molecular cloning of human eotaxin, an eosinophil selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J Biol Chem 271:7725, 1996
15. Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ: Molecular cloning, functional characterization and signaling characteristics of a CC chemokine receptor. Cell 72:415, 1993
16. He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S, Busciglio J, Yang X, Hoffmann W, Newman W, Mackay CR, Sodroski J, Gabuzda D: CCR-3 and CCR-5 are co-receptors for HIV-I infection of microglia. Nature 385:645, 1997
17. Sallusto F, Mackay CR, Lanzavecchia A: Selective expression of the eotaxin receptor CCR-3 by human T helper 2 cells. Science 277:2005, 1997
18. Gerber BO, Zanni MP, Uguccioni M, Loetscher M, Mackay CR, Pichler WJ, Yawalkar N, Baggiolini M, Moser B: Functional expression of the eotaxin receptor CCR-3 in T lymphocytes co-localizing with eosinophils. Curr Biol 7:836, 1997
19. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J: The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135, 1996
20. Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW: A dual-tropic primary HIV-1 isolate that uses fusin and the b-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion co-factors. Cell 85:1149, 1996
21. Rothenberg ME, MacLean JA, Pearlman E, Luster AD, Leder P: Targeted disruption of the chemokine eotaxin partially reduces antigeninduced tissue eosinophilia. J Exp Med 4:785, 1997
22. Bacon KB, Camp RDR, Cunningham FM, Woollard PM: Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid. Br J Pharmacol 95:966, 1988
23. Bacon KB, Premack B, Gardner P, Schall T: Activation of dual T cell signaling pathways by the chemokine RANTES. Science 269:1727, 1995
24. Heath H, Qin SX, Rao P, Wu LJ, LaRosa G, Kassam N, Ponath PD, Mackay CR: Chemokine receptor useage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest 99:178, 1997
25. Dairaghi DJ, Oldham ER, Bacon KB, Schall TJ: Chemokine receptor CCR3 function is highly dependent on local pH and ionic strength. J Biol Chem 272:28206, 1997
26. Zhang I, He T, Talal A, Wang G, Frankel SS, Ho DD: In vivo distribution of the human immunodeficiency virus simian immunodeficiency virus co-receptors: CXCR4, CCR3 and CCR5. J Virol 72:5035, 1998
27. Dairaghi DJ, Franz-Bacon K, Callas E, Cupp J, Schall TJ, Tamraz SA, Boehme SA, Taylor N, Bacon KB: Macrophage inflammatory protein-1β induces migration and activation of human thymocytes. Blood 91:2905, 1998
28. Baggiolini M, Dewald B, Moser M: Interleukin-8 and related chemotctic cytokines - CXC and CC chemokines. Adv Immunol 55:97, 1994
29. Bacon KB, Schall TJ: Chemokines as mediators of allergic inflammation. Int Arch Allergy Immunol 109:97, 1996
30. Rollins BJ: Chemokines. Blood 90:909, 1997
31. Kim JJ, Nottingham LK, Sin JI, Tsai A, Morrison L, Oh J, Dang K, Hu Y, Kazahaya K, Bennett M, Dentchev T, Wilson DM, Chalian AA, Boyer JD, Agadjanyan MG, Weiner DB: CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. J Clin Invest 102:1112, 1998
32. D'Ambrosio D, Iellem A, Bonecchi R, Mazzeo D, Sozzani S, Mantovani A, Sinigaglia F: Selective upregulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J Immunol 161:5111, 1998
33. Weng, W, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA: Binding and functional properties of recombinant and exogenous CXCR3 chemokine receptors. J Biol Chem 272:18288, 1998