Comparison of clinical and demographic features between affected pairs of Italian Multiple Sclerosis multiplex families; relation to tumour necrosis factor genomic polymorphisms

Journal of the Neurological Sciences

Volumn 162, Issue 2, 1999, Pages 194-200

  Trojano, M ^a   Liguori, M ^a   De Robertis, F ^a   Stella, A ^a   Guanti, G ^a   Avolio, C ^a   Livrea, P ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Clinical features; Demographic features; Microsatellites; Multiple Sclerosis Multiplex Families; Tumor necrosis factor and loci

Indexed keywords

LYMPHOTOXIN; MICROSATELLITE DNA; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ALLELISM; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DEMOGRAPHY; DISEASE COURSE; DISEASE PREDISPOSITION; DNA POLYMORPHISM; ENVIRONMENTAL FACTOR; FEMALE; HAPLOTYPE; HEREDITY; HUMAN; ITALY; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; SIBLING;

ADULT; AGED; DEMOGRAPHY; FEMALE; GENOME, HUMAN; HUMANS; ITALY; MALE; MATCHED-PAIR ANALYSIS; MIDDLE AGED; MULTIPLE SCLEROSIS; PEDIGREE; POLYMORPHISM, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033556578     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(98)00328-1     Document Type: Article

References (50)

1. Bulman D.E., et al. Age of onset in siblings concordant for Multiple Sclerosis. Brain. 114:1991;937-950.
2. Confavreux C., et al. EDMUS, a European database for multiple sclerosis. J Neurol Neurosurg Psychiatry. 55:1992;671-676.
3. Doolittle T.H., et al. Multiple Sclerosis sibling pairs: clustered onset and familial predisposition. Neurology. 40:1990;1546-1552.
4. Droogan A.G., et al. T-cell receptor alpha, beta, gamma and delta chain microsatellites show no association with multiple sclerosis. Neurology. 47:1996;1049-1053.
5. Ebers G.C., et al. A genetic basis for familial aggregation in multiple sclerosis. Nature. 377:1995;150-151.
6. Ebers G.C. Genetic epidemiology of multiple sclerosis. Curr Opin Neurol. 9:1996;155-158.
7. Ebers G.C. A full genome search in multiple sclerosis. Nat Genet. 13:1996;472-476.
8. Eoli M., et al. Evidence of linkage between susceptibility to multiple sclerosis and HLA-class II loci in Italian Multiplex Families. Eur J Hum Genet. 3:1995;303-311.
9. Fodgell A., et al. Linkage analysis of HLA class II genes in Swedish multiplex families with multiple sclerosis. Neurology. 48:1997;758-762.
10. Fugger L., et al. Tumor necrosis factor alpha gene polymorphisms in multiple sclerosis and optic neuritis. J Neuroimmunol. 27:1990;85-88.
11. Graham C.A., et al. Lack of association between myelin basic protein gene microsatellites and Multiple Sclerosis. Lancet. 341:1993;1596.
12. Gusev E.I., et al. TNF gene polymorphisms: associations with multiple sclerosis susceptibility and severity. Abramsky O., Ovadia H. Frontiers in Multiple Sclerosis. Clinical Research and Therapy. 1997;35-41 Martin Dunitz Ltd.
13. Harper, P.S., Myotonic dystrophy, in: Saunders WB (Ed.), Philadelphia, 1979, 219-23.
14. Hashimoto L.L., et al. Immunoglobulin heavy chain variable region polymorphisms in Multiple Sclerosis susceptibility. J Neuroimmunol. 44:1993;77-83.
15. He B., et al. Tumor necrosis factor α 308 in multiple sclerosis and optic neuritis. J Neuroimmunol. 63:1995;143-147.
16. Kirk C.W., et al. Tumor necrosis factor microsatellites show association with multiple sclerosis. J Neurol Sci. 147:1997;21-25.
17. Koch-Henrikson N. An epidemiological study of multiple sclerosis. Acta Neurol Scand. 80:(suppl):1989;12-23.
18. Kurtzke J.F. Epidemiological contribution to MS: an overview. Neurology. 30:1980;61-79.
19. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 33:1983;1444-1452.
20. Maimone D., et al. Cytokyne levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. J Neuroimmunol. 32:1991;67-74.
21. Marrosu M.G., et al. HLA-DQB1 genotype in Sardinian multiple sclerosis: evidence for a key role of DQB1*0201 and*0302 alleles. Neurology. 42:1992;883-886.
22. Mumford C.J., et al. Multiple sclerosis in the Cambridge Health Authority. J Neurol Neurosurg Psychiatry. 55:1992;877-882.
23. Mumford C.J., et al. The British Isles survey of multiple sclerosis in twins. Neurology. 44:1994;5-11.
24. Nedospasov S.A., et al. Tandem arrangement of genes coding for tumor necrosis Factor (TNF-α) and Lymphotoxin (TNF-β) in the human genome. Cold Spring Harbor Symp Quant Biol. 51:1986;611-625.
25. Poser C.M., et al. New diagnostic criteria for multiple sclerosis: guide-lines for research protocols. Ann Neurol. 13:1983;227-231.
26. Powell M.B., et al. Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int Immunol. 2:1990;540-544.
27. Rice-Oxley M., et al. A prevalent survey of multiple sclerosis in Sussex. J Neurol Neurosurg Psychiatry. 58:1995;27-30.
28. Robertson N.P., et al. Clinical concordance in sibling pairs with multiple sclerosis. Neurology. 47:1996;347-352.
29. Robertson N., et al. Age-adjusted recurrence risks for relatives of patients with multiple sclerosis. Brain. 119:1996;449-455.
30. Rose J., et al. Genetic susceptibility in familial multiple sclerosis not linked to the myelin basic protein gene. Lancet. 341:1993;1596.
31. Roth M.P., et al. Tumor necrosis factor polymorphisms in multiple sclerosis: no additional association independent of HLA. J Neuroimmunol. 51:1994;93-99.
32. Sadovnick A.D., et al. Multiple sclerosis: updated risks for relatives. Am J Med Genet. 29:1988;533-541.
33. Sadovnick A.D., et al. Heterogeneity in Multiple Sclerosis: comparison of clinical manifestations in relatives. Can J Neurol Sci. 17:1990;387-390.
34. Sadovnick A.D., et al. The influence of gender on the susceptibility to multiple sclerosis in sibship. Arch Neurol. 48:1991;586-588.
35. Sadovnick A.D., et al. Evidence for genetic basis of multiple sclerosis. Lancet. 347:1996;1728-1730.
36. Sandberg-Wollheim M., et al. An evaluation of tumor necrosis factor microsatellites in genetic susceptibility of multiple sclerosis. Multiple Sclerosis. 1:1995;181-185.
37. Sawcer S., et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet. 13:1996;464-468.
38. Selmaj K., et al. Identification of Lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest. 87:1991;949-954.
39. Spurkland A., et al. HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis. Hum Immunol. 30:1991;69-75.
40. The Multiple Sclerosis Genetics Group (USA). A complete genomic screen for multiple sclerosis underscores a role for the major Histocompatibility complex, Nat Genet 1996 469-71.
41. Tienari P.J., et al. Genetic susceptibility to Multiple Sclerosis is linked to the myelin basic protein gene. Lancet. 340:1992;987-991.
42. Tienari P.G., et al. Reappraisal of HLA in multiple sclerosis: Close linkage in multiplex families. Eur J Hum Genet. 1993;257-268.
43. Trojano M., et al. Multivariate analysis of predictive factors of multiple sclerosis course with a validated method to assess clinical events. J Neurol Neurosurg Psychiatry. 58:1995;300-306.
44. Udalova I.A., et al. Highly informative typing of the human TNF locus using six adjacent polymorphic markers. Genomics. 16:1993;180-186.
45. Wei S., et al. Human T-cell receptor Vβ gene polymorphism and multiple sclerosis. Am J Hum Gen. 56:1995;963-969.
46. Weinshenker B.G., et al. A comparison of sporadic and familial multiple sclerosis. Neurology. 40:1990;1354-1358.
47. Weinshenker B.G., et al. Genetic variation in the tumor necrosis factor alpha gene and the outcome of multiple sclerosis. Neurology. 49:1997;378-385.
48. Weitkamp L.R. Multiple sclerosis susceptibility: interaction between sex and HLA. Arch Neurol. 40:1983;399-401.
49. Wood N.W., et al. A susceptibility gene for multiple sclerosis linked to the immunoglobulin heavy chain variable region. J Neurol. 242:1994;677-682.
50. Wood N.W., et al. No linkage or association between multiple sclerosis and myelin basic protein gene in affected sibling pairs. J Neurol Neurosurg Psychiatry. 57:1994;1191-1194.