The molecular basis of IFNγ action

Growth Factors and Cytokines in Health and Disease

Volumn 2, Issue C, 1997, Pages 521-556

  Dighe, Anand S ^a   Bach, Erika A ^a   Greenlund, Andrew C ^a   Schreiber, Robert D ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0345318658     PISSN: 18745687     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1874-5687(97)80035-3     Document Type: Review

References (155)

1. Adams D.O., and Hamilton T.A. The cell biology of macrophage activation. Annu. Rev. Immunol. 2 (1984) 283-318
2. Aguet M., and Merlin G. Purification of human gamma interferon receptors by sequential affinity chromatography on immobilized monoclonal anti-receptor antibodies and human gamma interferon. J. Exp. Med. 165 (1987) 988-999
3. Aguet M., Dembic Z., and Merlin G. Molecular cloning and expression of the human interferon-γ receptor. Cell 55 (1988) 273-280
4. Allen P.M., and Unanue E.R. Antigen processing and presentation at a molecular level. Adv. Exp. Med. Biol. 225 (1987) 147-154
5. 125I-human interferon-gamma to high affinity receptors on human fibroblasts. J. Biol. Chem. 257 (1982) 11301-11304
6. Arakawa T., Hsu Y.R., Parker C.G., and Lai P.H. Role of polycationic C-terminal portion in the structure and activity of recombinant human interferon-gamma. J. Biol. Chem. 261 (1986) 8534-8539
7. Bach E.A., Tanner J.W., Marsters S.A., Ashkenazi A., Aguet M., Shaw A.S., and Schreiber R.D. Ligand induced assembly and activation of the gamma interferon receptor in intact cells. Mol. Cell. Biol. 16 (1996) 3214-3221
8. Bancroft G.J., Schreiber R.D., Bosma G.C., Bosma M.J., and Unanue E.R. A T cell-independent mechanism of macrophage activation by interferon-gamma. J. Immunol. 139 (1987) 1104-1107
9. Bancroft G.J., Sheehan K.C.F., Schreiber R.D., and Unanue E.R. Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice. J. Immunol. 143 (1989) 127-130
10. Bancroft G.J., Schreiber R.D., and Unanue E.R. Natural immunity: A T-cell-independent pathway of macrophage activation, defined in the SCID mouse. Immunol. Rev. 124 (1991) 5-24
11. Basham T.Y., and Merigan T.C. Recombinant interferon-gamma increases HLA-DR synthesis and expression. J. Immunol. 130 (1983) 1492-1494
12. Basham T.Y., Nickoloff B.J., Merigan T.C., and Morhenn V.B. Recombinant gamma interferon differentially regulates class II antigen expression and biosynthesis on cultured normal human keratinocytes. J. Interferon Res. 5 (1985) 23-32
13. Basu M., Pace J.L., Pinson D.M., Hayes M.P., Trotta P.P., and Russell S.W. Purification and partial characterization of a receptor protein for mouse interferon gamma. Proc. Natl. Acad. Sci. USA 85 (1988) 6282-6286
14. Bazan J.F. Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 87 (1990) 6934-6938
15. Beckerman K.P., Rogers H.W., Corbett J.A., Schreiber R.D., McDaniel M.L., and Unanue E.R. Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. J. Immunol. 150 (1993) 888-895
16. Benoist C., and Mathis D. Regulation of major histocompatibility complex class II genes: X, Y, and other letters of the alphabet. Annu. Rev. Immunol. 8 (1990) 681-716
17. Beutler B., and Cerami A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 320 (1986) 584-588
18. Beutler B., Tkacenko V., Milsark I., Krochin N., and Cerami A. Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lps-d (endotoxin resistance) phenotype. J. Exp. Med. 164 (1986) 1791-1796
19. Billiau A. Interferons and inflammation. J. Interferon Res. 7 (1987) 559-567
20. Billiau A. Gamma-interferon: The match that lights the fire?. Immunol. Today 9 (1988) 37-40
21. Billiau A., Heremans H., Vandekerckhove F., and Dillen C. Anti-interferon gamma antibody protects mice against the generalized Schwartzman reaction. Eur. J. Immunol. 17 (1987) 1851
22. Boss J.M., and Strominger J.L. Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts. Proc. Natl. Acad. Sci. USA 83 (1986) 9139-9143
23. Brunda M.J., Luistro L., Warrier R.R., Wright R.B., Hubbard B.R., Murphy M., Wolf S.F., and Gately M.K. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J. Exp. Med. 178 (1993) 1223-1230
24. Buchmeier N.A., and Schreiber R.D. Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection. Proc. Natl. Acad. Sci. USA 82 (1985) 7404-7408
25. Calderon J., Sheehan K.C.F., Chance C., Thomas M.L., and Schreiber R.D. Purification and characterization of the human interferon-gamma receptor from placenta. Proc. Natl. Acad. Sci. USA 85 (1988) 4837-4841
26. Chan S.H., Kobayashi M., Santoli D., Perussia B., and Trinchieri G. Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12): Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2. J. Immunol. 148 (1992) 92-98
27. Chang T.W., McKinney S., Liu V., Kung P.C., Vilcek J., and Le J. Use of monoclonal antibodies as sensitive and specific probes for biologically active human gamma-interferon. Proc. Natl. Acad. Sci. USA 81 (1984) 5219-5222
28. Cofano F., Moore S.K., Tanaka S., Yuhki N., Landolfo S., and Applella E. Affinity purification, peptide analysis, and cDNA sequence of the mouse interferon-γ receptor. J. Biol. Chem. 265 (1990) 4064-4071
29. Cook J.R., Jung V., Schwartz B., Wang P., and Pestka S. Structural analysis of the human interferon-gamma receptor: A small segment of the intracellular domain is specifically required for class I major histocompatibility complex antigen induction and antiviral activity. Proc. Natl. Acad. Sci. USA 89 (1992) 11317-11321
30. Corbett J.A., Lancaster Jr. J.R., Sweetland M.A., and McDaniel M.L. Interleukin-1β-induced formation of EPR-detectable iron-nitrosyl complexes in Islets of Langerhans. J. Biol. Chem. 266 (1991) 21351
31. (Abstr.). Dalton D.K., Pitts-meek S., Figari I.S.F., Keshar S., Bradley A., and Stewart T.A. Mice with a targeted mutation of the IFNγ gene: Multiple defects in immune cell function. J. Interferon Res. (1992)
32. Darnell Jr. J.E., Kerr I.M., and Stark G.R. JAK-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264 (1994) 1415-1421
33. David M., Petricoin III E., Bejamin C., Pine R., Weber M.J., and Larner A.C. Requirement of MAP kinase (ERK2) activity in interferon α- and interferon β-stimulated gene expression through STAT proteins. Science 269 (1995) 1721-1723
34. Davies P., Bailey P.J., and Goldenberg M.M. The role of arachidonic acid oxygenation products in pain and inflammation. Ann. Rev. Immunol. 2 (1984) 335-357
35. De Maeyer E. The interferon system and the immune system. In: Vilcek J., and De Mayer E. (Eds). Interferons and the Immune System (1984), Elsevier, New York 1-6
36. Derynck R., Leung D.W., Gray P.W., and Goeddel D.V. Human interferon gamma is encoded by a single class of mRNA. Nucleic Acids Res. 10 (1982) 3605-3615
37. Dighe A.S., Farrar M.A., and Schreiber R.D. Inhibition of cellular responsiveness to interferon-γ (IFNγ) induced by overexpression of inactive forms of the IFNγ receptor. J. Biol. Chem. 268 (1993) 10645-10653
38. Dighe A.S., Richards E., Old L.J., and Schreiber R.D. Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors. Immunity 1 (1994) 447-456
39. Dighe A.S., Campbell D., Hsieh C.-S., Clarke S., Greaves D.R., Gordon S., Murphy K.M., and Schreiber R.D. Tissue specific targeting of cytokine unresponsiveness in transgenic mice. Immunity 3 (1995) 657-666
40. Ding A.H., Nathan C.F., and Stuehr D.J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: Comparison of activating cytokines and evidence for independent production. J. Immunol. 141 (1988) 2407-2412
41. Ealick S.E., Cook W.J., Vijay-Kumar S., Carson M., Nagabhushan T.L., Trotta P.P., and Bugg C.E. Three-dimensional structure of recombinant human interferon-gamma. Science 252 (1991) 698-702
42. Erbe D.V., Collins J.E., Shen L., Graziano R.F., and Fanger M.W. The effect of cytokines on the expression and function of Fc receptors for IgG on human myeloid cells. Mol. Cell. Biol. 27 (1990) 57-67
43. Farber J.M. A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc. Natl. Acad. Sci. USA 87 (1990) 5238-5242
44. Farrar M.A., and Schreiber R.D. The molecular cell biology of interferon-γ and its receptor. Annu. Rev. Immunol. 11 (1993) 571-611
45. Farrar M.A., Fernandez-Luna J., and Schreiber R.D. Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function. J. Biol. Chem. 266 (1991) 19626-19635
46. Farrar M.A., Campbell J.D., and Schreiber R.D. A point mutational analysis of the intracellular domain of human IFNg receptor. J. Interferon Res. (1992)
47. Farrar M.A., Campbell J.D., and Schreiber R.D. Identification of a functionally important sequence motif in the carboxy terminus of the interferon-g receptor. Proc. Natl. Acad. Sci. USA 89 (1992) 11706-11710
48. Finbloom D.S., Hoover D.L., and Wahl L.M. The characteristics of binding of human recombinant interferon-gamma to its receptor on human monocytes and human monocyte-like cell lines. J. Immunol. 135 (1985) 300-305
49. Finkelman F.D., Holmes J., Katona I.M., Urban Jr. J.F., Beckmann M.P., Park L.S., Schooley K.A., Coffman R.L., Mosmann T.R., and Paul W.E. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8 (1990) 303-333
50. Fischer T., Rehm A., Aguet M., and Pfizenmaier K. Human chromosome 21 is necessary and sufficient to confer human IFNγ responsiveness to somatic cell hybrids expressing the cloned human IFNγ receptor gene. Cytokine 2 (1990) 157-161
51. Fischer T., Thoma B., Scheurich P., and Pfizenmaier K. Glycosylation of the human interferon-gamma receptor. N-linked carbohydrates contribute to structural heterogeneity and are required for ligand binding. J. Biol. Chem. 265 (1990) 1710-1717
52. Flesch I., Hess J.H., Huang S., Aguet M., Rothe J., Bluethmann H., and Kaufmann S.H.E. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α. J. Exp. Med. 181 (1995) 1615-1621
53. Fountoulakis M., Kania M., Ozmen L., Loetscher H.R., Garotta G., and van Loon A.P. Structure and membrane topology of the high-affinity receptor for human IFN-gamma: Requirements for binding IFN-gamma. One single 90-kilodalton IFN-gamma receptor can lead to multiple cross-linked products and isolated proteins. J. Immunol. 143 (1989) 3266-3276
54. Fountoulakis M., Zulauf M., Lustig A., and Garotta G. Stoichiometry of interaction between interferon-γ and its receptor. Eur. J. Biochem. 208 (1992) 781-787
55. Frohman E.M., Frohman T.C., Dustin M.L., Vayuvegula B., Choi B., Gupta A., van den Noort S., and Gupta S. The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma, tumor necrosis factor alpha, lymphotoxin, and interleukin-1: Relevance to intracerebral antigen presentation. J. Neuroimmunol. 23 (1989) 117-124
56. Gajewski T.F., and Fitch F.W. Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 140 (1988) 4245-4252
57. Gajewski T.F., Joyce J., and Fitch F.W. Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma. J. Immunol. 143 (1989) 15-22
58. Gajewski T.F., Schell S.R., Nau G., and Fitch F.W. Regulation of T-Cell Activation: Differences among T cell subsets. Immunol. Rev. 111 (1989) 79-110
59. Glimcher L.H., and Kara C.J. Sequences and factors: A guide to MHC class II transcription. Annu. Rev. Immunol. 10 (1992) 13-50
60. Grau G.E., Heremans H., Piguet P.F., Pointaire P., Lambert P.H., Billiau A., and Vassalli P. Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor. Proc. Natl. Acad. Sci. USA 86 (1989) 5572-5574
61. Gray P.W., and Goeddel D.V. Structure of the human immune interferon gene. Nature 298 (1982) 859-863
62. Gray P.W., and Goeddel D.V. Cloning and expression of murine immune interferon cDNA. Proc. Natl. Acad. Sci. USA 80 (1983) 5842-5846
63. Gray P.W., Leung D.W., Pennica D., Yelverton E., Najarian R., Simonsen C.C., Derynck R., Sherwood P.J., Wallace D.M., Berger S.L., Levinson A.D., and Goeddel D.V. Expression of human immune interferon cDNA in E. coli and monkey cells. Nature 295 (1982) 503-508
64. Gray P.W., Leong S., Fennie E.H., Farrar M.A., Pingel J.T., Fernandez-Luna J., and Schreiber R.D. Cloning and expression of the cDNA for the murine interferon gamma receptor. Proc. Natl. Acad. Sci. USA 86 (1989) 8497-8501
65. Green S.J., Crawford R.M., Hockmeyer J.T., Meltzer M.S., and Nacy C.A. Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha. J. Immunol. 145 (1990) 4290-4297
66. Greenlund A.C., Schreiber R.D., Goeddel D.V., and Pennica D. Interferon-γ induces receptor dimerization in solution and on cells. J. Biol. Chem. 268 (1993) 18103-18110
67. Greenlund A.C., Farrar M.A., Viviano B.L., and Schreiber R.D. Ligand induced IFNγ receptor phosphorylation couples the receptor to its signal transduction system (p91). EMBO J. 13 (1994) 1591-1600
68. Greenlund A.C., Morales M.O., Viviano B.L., Yan H., Krolewski J., and Schreiber R.D. Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process. Immunity 2 (1995) 677-687
69. Handa K., Suzuki R., Matsui H., Shimizu Y., and Kumagai K. Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production. J. Immunol. 130 (1983) 988-992
70. Heinzel F.P. The role of IFN-gamma in the pathology of experimental endotoxemia. J. Immunol. 145 (1990) 2920-2924
71. Hemmi S., Peghini P., Metzler M., Merlin G., Dembic Z., and Aguet M. Cloning of murine interferon gamma receptor cDNA: Expression in human cells mediates high-affinity binding but is not sufficient to confer sensitivity to murine interferon gamma. Proc. Natl. Acad. Sci. USA 86 (1989) 9901-9905
72. Hemmi S., Bohni R., Stark G., DiMarco F., and Aguet M. A novel member of the interferon receptor family complements functionality of the murine interferon-gamma receptor in human cells. Cell 76 (1994) 803-810
73. Heremans H., Dijkmans R., Sobis H., Vandekerckhove F., and Billiau A. Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide. J. Immunol. 138 (1987) 4175-4179
74. Heremans H., Van Damme J., Dillen C., Dijkmans R., and Billiau A. Interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice. J. Exp. Med. 171 (1990) 1853-1869
75. Hershey G.K., and Schreiber R.D. Biosynthetic analysis of the human interferon-gamma receptor. Identification of N-linked glycosylation intermediates. J. Biol. Chem. 264 (1989) 11981-11988
76. Hibbs Jr. J.B., Taintor R.R., Vavrin Z., Granger D.L., Drapier J.-C., Amber I.J., and Lancaster Jr. J.R. Synthesis of nitric oxide from a terminal guanidino nitrogen atom of L-arginine: A molecular mechanism regulating cellular proliferation that targets intracellular iron. In: Moncado S., and Higgs E.A. (Eds). Nitric Oxide from L-arginine: A Bioregulatory System (1990), Elsevier Science, Amsterdam 189-222
77. Hibino Y., Mariano T.M., Kumar C.S., Kozak C.A., and Pestka S. Expression and reconstitution of a biologically active mouse interferon gamma receptor in hamster cells. Chromosomal location of an accessory factor. J. Biol. Chem. 266 (1991) 6948-6951
78. Ho A.S.Y., Liu Y., Khan T.A., Hsu D.-H., Bazan J.F., and Moore K.W. A receptor for interleukin-10 is related to interferon receptors. Proc. Natl. Acad. Sci. USA 90 (1993) 11267-11271
79. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260 (1993) 547-549
80. + αβ-TCR transgenic T cells is macrophage dependent. Intl. Immunol. 5 (1993) 371-382
81. Huang S., Hendriks W., Althage A., Hemmi S., Bluethmann H., Kamijo R., Vilcek J., Zinkernagel R., and Aguet M. Immune response in mice that lack the interferon-γ receptor. Science 259 (1993) 1742-1745
82. Huang A.Y., Golumbek P., Ahmadzadeh M., Jaffee E., Pardoll D., and Levitsky H. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264 (1995) 961-965
83. Igarashi K., Garotta G., Ozmen L., Ziemiecki A., Wilks A.F., Harpur A.G., Larner A.C., and Finbloom D.S. Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor. J. Biol. Chem. 269 (1994) 14333-14336
84. Johnson K.P., and Panitch H.S. Effects of experimental recombinant interferons on multiple sclerosis. Trans. Am. Clin. Climatolog. Assoc. 100 (1988) 171-176
85. Jung V., Rashidbaigi A., Jones C., Tischfield J.A., Shows T.B., and Pestka S. Human chromosomes 6 and 21 are required for sensitivity to human interferon gamma. Proc. Natl. Acad. Sci. USA 84 (1987) 4151-4155
86. Jung V., Jones C., Kumar C.S., Stefanos S., O'Connell S., and Pestka S. Expression and reconstitution of a biologically active human IFNγ receptor in hamster cells. J. Biol. Chem. 265 (1990) 1827-1830
87. Kaplan D.K., Greenlund A.C., Tanner J.W., Shaw A.S., and Schreiber R.D. Identification of an interferon-γ receptor α chain sequence required for JAK-1 binding. J. Biol. Chem. 271 (1996) 9-12
88. Kotenko S., Izotova L., Pollack B., Mariano T., Donnelly R., Muthukumaran G., Cook J., Garrotta G., Silvennoinen O., Ihle J., and Pestka S. Interaction between the components of the interferon gamma receptor complex. J. Biol. Chem. 270 (1995) 20912-20915
89. Kumar C.S., Muthukumaran G., Frost L.J., Noe M., Ahn Y.H., Mariano T.M., and Pestka S. Molecular characterization of the murine interferon gamma receptor cDNA. J. Biol. Chem. 264 (1989) 17939-17946
90. Langer J.S., and Pestka S. Interferon receptors. Immunol. Today 9 (1988) 393-400
91. Le J., Chang T.W., Liu V., Yip Y.K., and Vilcek J. Monoclonal antibodies as structural probes for oligomeric human interferon-gamma. J. Interferon Res. 5 (1985) 445-453
92. Liew F.Y., Li Y., and Millott S. Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide. J. Immunol. 145 (1990) 4306-4310
93. Littman S.J., Faltynek C.R., and Baglioni C. Binding of human recombinant 125I-interferon gamma to receptors on human cells. J. Biol. Chem. 260 (1985) 1191-1195
94. Lorence R.M., Edwards C.K., Walter R.J., Kelley K.W., and Greager J.A. In vivo effects of recombinant interferon-gamma: Augmentation of endotoxin-induced necrosis of tumors and priming of macrophages for tumor necrosis factor-alpha production. Cancer Lett. 53 (1990) 223-229
95. Lowenstein C.J., and Snyder S.H. Nitric oxide, a novel biologic messenger. Cell 70 (1992) 705-707
96. Mantovani A., and Dejana E. Cytokines as communication signals between leukocytes and endothelial cells. Immunol. Today 10 (1989) 370-375
97. Mao C., Aguet M., and Merlin G. Molecular characterization of the human interferon-gamma receptor: Analysis of polymorphism and glycosylation. J. Interferon Res. 9 (1989) 659-669
98. Marsters S., Pennica D., Bach E., Schreiber R.D., and Ashkenazi A. Interferon γ signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain. Proc. Natl. Acad. Sci. USA 92 (1995) 5401-5405
99. Matsumura H., and Nakano M. Endotoxin-induced interferon-gamma production in culture cells derived from BCG-infected C3H/HeJ mice. J. Immunol. 140 (1988) 494-500
100. Miura O., Cleveland J.L., and Ihle J.N. Inactivation of erythropoietin receptor function by point mutation in a region having homology with other cytokine receptors. Mol. Cell. Biol. 13 (1993) 1788-1795
101. Mond J.J., Carman J., Sarma C., Ohara J., and Finkelman F.D. Interferon-gamma suppresses B cell stimulation factor (BSF-1) induction of class II MHC determinants on B cells. J. Immunol. 137 (1986) 3534-3537
102. Moore K.W., O'Garra A.O., de Waal Malefyt R., Vieira P., and Mosmann T.R. Interleukin-10. Ann. Rev. Immunol. 11 (1993) 165-190
103. Mosmann T.R., and Coffman R.L. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7 (1989) 145-173
104. Movat H.Z., Burrowes C.E., Cybulsky M.I., and Dinarello C.A. Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Synergistic action of the cytokines in the induction of inflammation and microvascular injury. Am. J. Pathol. 129 (1987) 463-476
105. Müller M., Briscoe J., Laxton C., Guschin D., Zlemleckl A., Silvennoinen O., Harpur A.G., Barbier G., Witthuhn B.A., Schindler C., Pellegrini S., Wilks A.F., Ihle J.N., Stark G.R., and Kerr I.M. The protein tyrosine kinase JAK1 complements a mutant cell line defective in the interferon-alpha/beta and -gamma signal transduction pathways. Nature 366 (1993) 129-135
106. Munro S., and Maniatis T. Expression and cloning of the murine interferon-γ receptor cDNA. Proc. Natl. Acad. Sci. USA 86 (1989) 9248-9252
107. Munro J.M., Pober J.S., and Cotran R.S. Tumor necrosis factor and interferon-gamma induce distinct patterns of endothelial activation and associated leukocyte accumulation in skin of papio anubis. Am. J. Pathol. 135 (1989) 121-131
108. Murakami M., Narazaki M., Hibi M., Yawata H., Yasukawa K., Hamaguchi M., and Kishimoto T. Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc. Natl. Acad. Sci. USA 88 (1991) 11349-11353
109. Nagata K., Izumi T., Kitagawa T., and Yoshida N. Oligomeric structure of recombinant human and murine immune interferons by means of sedimentation equilibrium. J. Interferon Res. 7 (1987) 313-320
110. Nastala C.L., Edington H.D., McKinney T.G., Tahara H., Nalesnik M.A., Brunda M.J., Gately M.K., Wolf S.F., Schreiber R.D., Storkus W.J., and Lotze M.T. Recombinant IL-12 administration induces tumor regression in association with IFN-γ production. J. Immunol. 153 (1994) 1697-1706
111. Naylor S.L., Sakaguchi A.Y., Shows T.B., Law M.L., Goeddel D.V., and Gray P.W. Human immune interferon gene is located on chromosome 12. J. Exp. Med. 157 (1983) 1020-1027
112. Naylor S.L., Gray P.W., and Lalley P.A. Mouse immune interferon (IFNγ) gene is on human chromosome 10. Somat. Cell. Mol. Genet. 10 (1984) 531-534
113. Novick D., Orchansky P., Revel M., and Rubinstein M. The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies. J. Biol. Chem. 262 (1987) 8483-8487
114. Old L.J. Tumor necrosis factor (TNF). Science 230 (1985) 630-632
115. Old L.J. Tumor necrosis factor. Scientific Am. 258 (1988) 59-75
116. Pace J.L., Russell S.W., LeBlanc P.A., and Murasko D.M. Comparative effects of various classes of mouse interferons on macrophage activation for tumor cell killing. J. Immunol. 134 (1985) 977-981
117. Pestka S., Langer J.A., Zoon K.C., and Samuel C.E. Interferons and their actions. Annu. Rev. Biochem. 56 (1987) 727-777
118. Pfizenmaier K., Wiegmann K., Scheurich P., Krönke M., Merlin G., Aguet M., Knowles B.B., and Ucer U. High affinity human IFN-gamma-binding capacity is encoded by a single receptor gene located in proximity to c-ros on human chromosome region 6q16 to 6q22. J. Immunol. 141 (1988) 856-860
119. Pfizenmaier K., Himmler A., Schutze S., Scheurich P., and Kronke M. TNF receptors and TNF signal transduction. In: Beutler B. (Ed). Tumor Necrosis Factors: The Molecules and Their Emerging Role in Medicine (1992), Raven Press, Ltd., Amsterdam 439-472
120. Pober J.S., Gimbrone Jr. M.A., Lapierre L.A., Mendrick D.L., Fiers W., Rothlein R., and Springer T.A. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J. Immunol. 137 (1986) 1893-1896
121. Sakatsume M., Igarashi K., Winestock K.D., Garotta G., Larner A.C., and Finbloom D.S. The Jak kinases differentially associate with the alpha and beta (Accessory Factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. J. Biol. Chem. 270 (1995) 17528-17534
122. Scahill S.J., Devos R., Van der Heyden J., and Fiers W. Expression and characterization of the product of a human immune interferon cDNA gene in Chinese hamster ovary cells. Proc. Natl. Acad. Sci. USA 80 (1983) 4654-4658
123. Schindler C., Shuai K., Prezioso V.R., and Darnell Jr. J.E. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257 (1992) 809-813
124. Schreiber R.D. Validation of a role for endogenously produced IFNγ in resolution of Listeria Monocytogenes infection in mice. In: Eisenstein T.K., Bullock W.E., and Hanna N. (Eds). Host Defenses and Immunomodulation to Intracellular Pathogens (1986), Plenum Publishing Co., New York
125. Schreiber R.D., and Celada A. Molecular characterization of interferon gamma as a macrophage activating factor. Lymphokines 11 (1985) 87-118
126. Schreiber R.D., and Aguet M. The interferon-γ receptor. Guidebook to Cytokines and Their Receptors (1994), Oxford University Press, Philadelphia 120-123
127. Schreiber R.D., Pace J.L., Russell S.W., Altman A., and Katz D.H. Macrophage-activating factor produced by a T cell hybridoma: Physiochemical and biosynthetic resemblance to gamma-interferon. J. Immunol. 131 (1983) 826-832
128. Schreiber R.D., and Sheehan K.C.F. The use of monoclonal antibodies to study the physiologic roles of murine cytokines. In: Baxter A., and Ross R. (Eds). Cytokine Interactions and Their Control (1991), John Wiley & Sons, New York 105-116
129. Schreiber R.D., Hicks L.J., Celada A., Buchmeier N.A., and Gray P.W. Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity. J. Immunol. 134 (1985) 1609-1618
130. Scott P. IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous Leishmaniasis. J. Immunol. 147 (1991) 3149-3155
131. Shuai K., Schindler C., Prezioso V.R., and Darnell Jr. J.E. Activation of transcription by IFN-γ. Tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258 (1992) 1808-1812
132. Snapper C.M., and Paul W.E. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236 (1987) 944-947
133. Soh J., Donnely R.O., Kotenko S., Mariano T.M., Cook J.R., Wang N., Emanuel S., Schwartz B., Miki T., and Pestka S. Identification and sequence of an accessory factor required for activation of the human IFN-gamma receptor. Cell 76 (1994) 793-802
134. Stefanos S., Ahn Y.H., and Pestka S. Characterization of human interferon-gamma receptor purified from placenta. J. Interferon Res. 9 (1989) 719-730
135. Stern A.S., Podlaski F.J., Hulmes J.D., Pan Y.E., Quinn P.M., Wolitzky A.G., Familletti P.C., Stremlo D.L., Truitt T., Chizzonite R., and Gately M.K. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87 (1990) 6808-6812
136. Stewart W.E. The Interferons (1979), Springer-Verlag, New York
137. Stone-Wolff D.S., Yip Y.K., Kelker H.C., Le J., Henriksen-DeStefano D., Rubin B.Y., Rinderknecht E., Aggarwal B.B., and Vilĉek J. Interrelationships of human interferon-gamma with lymphotoxin and monocyte cytotoxin. J. Exp. Med. 159 (1984) 828-843
138. Street N.E., Schumacher J.H., Fong T.A.T., Bass H., Fiorentino D.F., Leverah J.A., and Mosmann T.R. Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells. J. Immunol. 144 (1990) 1629-1639
139. Strunk R.C., Cole F.S., Perlmutter D.H., and Colten H.R. gamma-Interferon increases expression of class III complement genes C2 and factor B in human monocytes and in murine fibroblasts transfected with human C2 and factor B genes. J. Biol. Chem. 260 (1985) 15280-15285
140. Suzuki Y., Orellana M.A., Schreiber R.D., and Remington J.S. Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science 240 (1988) 516-518
141. Tracey K.J., Beutler B., Lowry S.F., Merryweather J., Wolpe S., Milsark J.W., Hariri R.J., Fahey T.J., Zentella A., Albert J.P., Shures G.T., and Cerami A. Shock and tissue injury induced by recombinant human cachectin. Science 234 (1986) 470-474
142. Trent J.M., Olson S., and Lawn R.M. Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization. Proc. Natl. Acad. Sci. USA 79 (1982) 7809-7813
143. Trinchieri G., and Perussia B. Immune interferon: A pleiotropic lymphokine with multiple effects. Immunol. Today 6 (1985) 131-136
144. Tripp C.S., Wolf S.F., and Unanue E.R. Interleukin-12 and tumor necrosis factor alpha are costimulators of interferon-gamma production by natural killer cells in severe combined immunodeficiency mice with Listeriosis, and interleukin-10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90 (1993) 3725-3729
145. Ucer U., Bartsch H., Scheurich P., Berkovic D., Ertel C., and Pfizenmaier K. Quantitation and characterization of gamma-interferon receptors on human tumor cells. Cancer Res. 46 (1986) 5339-5343
146. Van Loon A.P.G.M., Ozmen L., Fountoulakis M., Kania M., Haiker M., and Garotta G. High-affinity receptor for interferon-gamma (IFN-gamma), a ubiquitous protein occurring in different molecular forms on human cells: Blood monocytes and eleven different cell lines have the same IFN-gamma receptor protein. J. Leuko. Biol. 49 (1991) 462-473
147. Vilcek J., Gray P.W., Rinderknecht E., and Sevastopoulos C.G. Interferon gamma: a lymphokine for all seasons. Lymphokines 11 (1985) 1-32
148. Walter M.R., Windsor W.T., Nagabhushan T.L., Lundell D.J., Lunn C.A., Zauodny P.J., and Narula S.W. Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor. Nature 376 (1995) 230-235
149. Wang Z.-E., Reiner S.L., Zheng S., Dalton D.K., and Locksley R.M. CD4+ effector cells default to the Th2 pathway in interferon-gamma deficient mice infected with Leishmania major. J. Exp. Med. 179 (1994) 1367-1371
150. Watling D., Guschin D., Muller M., Silvennoinen O., Witthuhn B.A., Quelle F.W., Rogers N.C., Schindler C., Stark G.R., Ihle J.N., and Kerr I.M. Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Nature 366 (1993) 166-170
151. Wen Z., Zhong Z., and Darnell J.E. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82 (1995) 241-250
152. Wherry J.C., Schreiber R.D., and Unanue E.R. Regulation of gamma interferon production by natural killer cells in scid mice: Roles of tumor necrosis factor and bacterial stimuli. Infect. Immun. 59 (1991) 1709-1715
153. Wietzerbin J., Gaudelet C., Aguet M., and Falcoff E. Binding and cross-linking of recombinant mouse interferon-gamma to receptors in mouse leukemic L1210 cells; interferon-gamma internalization and receptor down-regulation. J. Immunol. 136 (1986) 2451-2455
154. Wolf S.F., Temple P.A., Kobayashi M., Young D., Dicig M., Lowe L., Dzialo R., Fitz L., Ferenz C., Hewick R.M., Kelleher K., Herrmann S.H., Clark S.C., Azzoni L., Chan S.H., Trinchieri G., and Perussia B. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146 (1991) 3074-3080
155. Yphantis D.A., and Arakawa T. Sedimentation equilibrium measurements of recombinant DNA derived human interferon gamma. Biochemistry 26 (1987) 5422-5427