A highly efficient and selective synthesis of lissoclinolide featuring hydrogen transfer hydrozirconation, trans-selective Pd-catalyzed cross coupling of alkenylzirconiums with 1,1-dibromoalkenes and Ag-catalyzed lactonization providing (Z)-γ-alkylidenebutenolides

Tetrahedron Letters

Volumn 40, Issue 3, 1999, Pages 431-434

  Xu, Caiding ^a   Negishi, Ei ichi ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE DERIVATIVE; ANTIBIOTIC AGENT; BROMINE DERIVATIVE; LISSOCLINOLIDE; PALLADIUM; UNCLASSIFIED DRUG; ZIRCONIUM DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; DRUG ISOLATION; DRUG SYNTHESIS; GRAM NEGATIVE INFECTION; STEREOCHEMISTRY;

NEGIBACTERIA;

EID: 0033555262     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02394-6     Document Type: Article

References (24)

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24. Panek JS; Hu T. J. Org. Chem. 1997; 62: 4912. Note added in proof: After submission of this manuscript a paper reporting a different but related synthesis of lissoclinolide was brought to our attention [Rossi R, Bellina F, Biagetti M, Mannina L. Tetrahedron Lett. 1998; 39: 7799].