Highly efficient and selective procedures for the synthesis of γ-alkylidenebutenolides via palladium-catalyzed ene-yne coupling and palladium- or silver-catalyzed lactonization of (Z)-2-en-4-ynoic acids. Synthesis of rubrolides A, C, D, and E

Synthesis

Volumn , Issue 1, 1997, Pages 121-128

  Kotora, Matin ^a,f,g,h   Negishi, Ei Ichi ^a,b,c,d,e  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c TEIJIN LTD   (Japan)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e SYRACUSE UNIVERSITY   (United States)

^f CHARLES UNIVERSITY   (Czech Republic)

^g INSTITUTE OF CHEMICAL PROCESS FUNDAMENTALS   (Czech Republic)

^h INSTITUTE FOR MOLECULAR SCIENCE   (Japan)

Author keywords

(Z) halopropenoic acids; oxypalladation; palladium catalyzed cross coupling lactonization; rubrolides A, C, D, and E; alkylidenebutenolides

Indexed keywords

ANTIBIOTIC AGENT; BUTENOLIDE; RUBROLIDE A; RUBROLIDE C; RUBROLIDE D; RUBROLIDE E; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; IN VITRO STUDY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

EID: 0031057305     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1997-1513     Document Type: Article

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