Comparison of recombinant human PTH(1-34) (LY333334) with a C-terminally substituted analog of human PTH-related protein(1-34) (RS-66271): In vitro activity and in vivo pharmacological effects in rats

Journal of Bone and Mineral Research

Volumn 14, Issue 2, 1999, Pages 163-172

  Frolik, Charles A ^a   Cain, Ricky L ^a   Sato, Masahiko ^a   Harvey, Anita K ^a   Chandrasekhar, S ^a   Black, Elwood C ^a   Tashjian Jr , Armen H ^b   Hock, Janet M ^a  

^a ELI LILLY AND COMPANY   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE[1-34]; RS 66271; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BONE DENSITY; BONE MINERAL; CANCELLOUS BONE; CARBOXY TERMINAL SEQUENCE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; IN VIVO STUDY; LUMBAR SPINE; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; PEPTIDE SYNTHESIS; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TRABECULAR BONE;

ANIMALS; BINDING, COMPETITIVE; BONE DENSITY; BONE RESORPTION; CALCIUM; CATTLE; CELL LINE; HUMANS; MALE; MICE; ORGAN CULTURE TECHNIQUES; RATS; RATS, INBRED F344; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RECEPTORS, PARATHYROID HORMONE; SIGNAL TRANSDUCTION; TERIPARATIDE;

EID: 0032958426     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1999.14.2.163     Document Type: Article

References (46)

1. Hefti E, Trechsel U, Bonjour JP, Fleisch H, Schenk R 1982 Increase of whole-body calcium and skeletal mass in normal and osteoporotic adult rats treated with parathyroid hormone. Clin Sci 62:389-396.
2. Gunness-Hey M, Hock JM 1984 Increased trahecular bone mass in rats treated with human synthetic parathyroid hormone. Metab Bone Dis Rel Res 5:177-181.
3. Shen V, Dempster DW, Birchman R, Xu R, Lindsay R 1993 Loss of cancellous bone mass and connectivity in ovariectomized rats can be restored by combined treatment with parathyroid hormone and estradiol. J Clin Invest 91:2479-2487.
4. Shen V, Dempster DW, Mellish RW, Birchman R, Horbert W, Lindsay R 1992 Effects of combined and separate intermittent administration of low-dose human parathyroid hormone fragment (1-34) and 17 beta-estradiol on bone histomorphometry in ovariectomized rats with established osteopenia. Calcif Tissue Int 50:214-220.
5. Jerome CP, Johnson CS, Lees CJ 1995 Effect of treatment for 3 months with human parathyroid hormone 1-34 peptide in ovariectomized cynomolgus monkeys (macaca fasicularis). Bone 17 (Suppl 4):415S-420S.
6. Ejersted C, Andreassen TT, Oxlund H, Jorgensen PH, Bak B, Haggblad J, Torring O, Nilsson MHL 1993 Human parathyroid hormone (1-34) and (1-84) increase the mechanical strength and thickness of cortical bone in rats. J Bone Miner Res 8:1097-1101.
7. Kimmel DB, Bozzato RP, Kronis KA, Coble T, Sindrey D, Kwong P, Recker RR 1993 The effect of recombinant human (1-84) or synthetic human (1-34) parathyroid hormone on the skeleton of adult osteopenic ovariectomized rats. Endocrinology 132:1577-1584.
8. Hock JM, Fonseca J, Gunness-Hey M, Kemp BE, Martin TJ 1989 Comparison of the anabolic effects of synthetic parathyroid hormone-related protein (PTHrP) 1-34 and PTH 1-34 on bone in rats. Endocrinology 125:2022-2027.
9. Weir EC, Terwilliger G, Sartori L, Insogna KL 1992 Synthetic parathyroid hormone-like protein (1-74) is anabolic for bone in vivo. Calcif Tissue Int 51:30-34.
10. Suva LJ, Winslow GA. Wettenhall REH, Hammonds RG, Moseley JM, Diefenbach-Jagger H, Rodda CP, Kemp BE, Rodriguez H, Chen EY, Hudson PJ, Martin TJ, Wood WI 1987 A parathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression. Science 237:893-896.
11. Mangin M, Webb AC, Dreyer BE, Posillico JT, Ikeda K, Weir EC, Stewart AF, Bander NH, Milstone L, Barton DE, Francke U, Broadus AE 1988 Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proc Natl Acad Sci USA 85:597-601.
12. Juppner H, Abou-Samra A-B, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF Jr, Hock J, Potts JT Jr, Kronenberg HM, Segre GV 1991 A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024-1026.
13. Urena P, Kong X-F, Abou-Samra A-B, Juppner H, Kronenberg HM, Potts JT Jr, Segre GV 1993 Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues. Endocrinology 133:617-623.
14. Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF 1996 Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol Rev 76:127-173.
15. Massry SG, Fujita T (eds.) 1989 New Actions of Parathyroid Hormone. Plenum Press, New York, NY, U.S.A., pp. 474.
16. Cohen FE, Strewler GJ, Bradley MS, Carlquist M, Nilsson M, Ericsson M, Ciardelli TL, Nissenson RA 1991 Analogues of parathyroid hormone modified at positions 3 and 6: Effects on receptor binding and activation of adenyl cyclase in kidney and bone. J Biol Chem 266:1997-2004.
17. Lane NE, Kimmel DB, Nilsson MHL, Cohen FE, Newton S, Nissenson RA, Strewler GJ 1996 Bone-selective analogs of human PTH (1-34) increase bone formation in an ovariectomized rat model. J Bone Miner Res 11:614-625.
18. Garnse R, Bauer E, Cardinaux F, Feyen JHM, Gasser JA, Gombert FO, Seuwen K 1997 SDZ PTS 893: Pharmacological profile of a highly potent novel PTH analog. J Bone Miner Res 12 (Suppl 1):S317.
19. Gasser JA, Gombert FO, Cardinaux F 1997 SDZ PTS 893, a PTH-analog with improved therapeutic window in skeletally mature rats. J Bone Miner Res 12 (Suppl 1):S236.
20. Vickery BH, Avnur Z, Ho T, Krstenansky J 1993 RS-66271, a new agonist analogue of PTHrP, has increased bone formative potency in estrogen deplete rats. J Bone Miner Res 8 (Suppl 1):S141.
21. Vickery BH, Avnur Z, Cheng Y, Chiou S-S, Leaffer D, Caufield JP, Kimmel DB, Ho T, Krstenansky JL 1996 RS-66271, a C-terminally substituted analog of human parathyroid hormone-related protein (1-34). increases trabecular and cortical bone in ovariectomized, osteopenic rats. J Bone Miner Res 11:1943-1951.
22. Pellegrini M, Bisello A. Rosenblatt M, Chorev M, Mierke DF 1997 Conformational studies of RS-66271, an analog of parathyroid hormone-related protein with pronounced bone anabolic activity. J Med Chem 40:3025-3031.
23. Leaffer D, Sweeney M, Kellerman LA, Avnur Z, Krstenansky JL. Vickery BH, Caulfield JP 1995 Modulation of osteogenic cell ultrastructure by RS-23581, an analog of human parathyroid hormone (PTH)-related peptide-(1-34), and bovine PTH-(1-34). Endocrinology 136:3624-3631.
24. Yee JP, Monroe SE, Thiene K 1996 The effects of RS-66271, a novel hPTHrP (1-34) analog, on serum and urinary markers of PTH-like activity in health postmenopausal women. J Bone Miner Res 11 (Suppl 1):S454.
25. Yee J, Fine G, Scott L 1997 An injectable PTHrP (1-34) analog and postprandial effects on blood pressure and heart rate in postmenopausal women. J Bone Miner Res 12 (Suppl 1):S232.
26. Smith DP, Zhang X-Y, Frolik CA, Harvey A, Chandrasekhar S. Black EC, Hsiung HM 1996 Structure and functional expression of a complementary DNA for porcine parathyroid hormone/parathyroid hormone-related peptide receptor. Biochim Biophys Acta 1307:339-347.
27. Frolik CA, DeLarco JE 1987 Radioreceptor assays for transforming growth factors. Methods Enzymol 146:95-102.
28. Key JL, Wright DR, Tashjian AH Jr 1976 Bone resorption in organ culture: Inhibition by the divalent cation ionophores A23187 and X-537A. J Clin Invest 58:1327-1338.
29. Schelling SH, Wolfe HJ, Tashjian AH Jr 1980 Role of the osteoclast in prostaglandin E2-stimulated bone resorption: A correlative morphometric and biochemical analysis. Lab Invest 42:290-295.
30. Gunness-Hey M, Hock JM 1989 Loss of anabolic effect of parathyroid hormone on bone after discontinuation of hormone in rats. Bone 10:447-452.
31. Tsukazaki T, Ohtsuru A, Namba H, Oda J, Motomura K, Osaki M, Kiriyama T, Iwasaki K, Yamashita S 1996 Parathyroid hormone-related protein (PTHrP) action in rat articular chondrocytes: Comparison of PTH (1-34), PTHrP (1-34), PTHrP (1-141), PTHrP (100-114) and antisense oligonucleotides against PTHrP. J Endocrinol 150:359-368.
32. 1H NMR spectroscopy, distance geometry, and molecular dynamics calculations. Biochemistry 30:6936-6942.
33. Strickland LA, Bozzato RP, Kronis KA 1993 Structure of human parathyroid hormone (1-34) in the presence of solvents and micelles. Biochemistry 32:6050-6057.
34. 1H NMR spectroscopy and its biological implications. Biochemistry 33:1684-1693.
35. Barden JA, Cuthbertson RM 1993 Stabilized NMR structure of human parathyroid hormone (1-34). Eur J Biochem 215:315-321.
36. Neugebauer W, Barbier J-R, Sung WL, Whitfield JF, Willick GE 1995 Solution structure and adenylyl cyclase stimulating activities of C-terminal truncated human parathyroid hormone analogues. Biochemistry 34:8835-8842.
37. Willis KJ 1994 Interaction with model membrane systems induces secondary structure in amino-terminal fragments of parathyroid hormone related protein. Int J Pept Protein Res 43:23-28.
38. 26] (1-34) amide. Biochem Biophys Acta 1208:256-262.
39. Jobert A-S, Fernandes I, Turner G, Coureau C, Prie D, Nissenson RA, Friedlander G, Silve C 1996 Expression of alternatively spliced isoforms of the parathyroid hormone (PTH)/ PTH-related peptide receptor messenger RNA in human kidney and bone cells. Mol Endocrinol 10:1066-1076.
40. Finkelstein JS, Klibanski A, Schaefer EH, Hornstein MD, Schiff I, Neer RM 1994 Parathyroid hormone for the prevention of bone loss induced by estrogen deficiency. N Engl J Med 331:1618-1623.
41. Lindsay R, Nieves J, Formica C, Henneman E, Woelfert L, Shen V, Dempster D, Cosman F 1997 Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis. Lancet 350:550-555.
42. Fraher LJ, Klein K, Marier R, Freeman D, Hendy GN, Goltzman D, Hodsman AB 1995 Comparison of the pharmacokinetics of parental parathyroid hormone-(1-34) [PTH-(1-34) ] and PTH-related peptide-(1-34) in healthy young humans. J Clin Endocrinol Metab 80:60-64.
43. Wuthier RE, Register TC 1985 Role of alkaline phosphatase, a polyfunctional enzyme, in mineralizing tissues. In: Butler WT (ed.) The Chemistry and Biology of Mineralized Tissues. EBSCO Media, Birmingham, AL, U.S.A., pp. 113-124.
44. Fleet JC, Bruns E, Hock JM, Wood RJ 1994 Growth hormone and parathyroid hormone stimulate intestinal calcium absorption in aged female rats. Endocrinology 134:1755-1760.
45. Toromanoff A, Ammann P, Mosekilde L, Thomsen JS, Riond J-L 1997 Parathyroid hormone increases bone formation and improves mineral balance in vitamin D-deficient female rats. Endocrinology 138:2449-2457.
46. de Rouffignac C, Quamme G 1994 Renal magnesium handling and its hormonal control. Physiol Rev 74:305-322.