Gender differences in the relation between comorbidity and mortality of patients with Alzheimer's disease

Neurology

Volumn 53, Issue 3, 1999, Pages 508-516

  Gambassi, Giovanni ^a,b,c   Lapane, K L ^b,c   Landi, F ^a   Sgadari, A ^a   Mor, V ^b,c   Bernabei, R ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b BROWN UNIVERSITY   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; COGNITIVE DEFECT; COMORBIDITY; DAILY LIFE ACTIVITY; DEMENTIA; FEMALE; GEOGRAPHIC DISTRIBUTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PHYSICAL DISABILITY; PREVALENCE; PRIORITY JOURNAL; SEX DIFFERENCE;

EID: 0033546634     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.53.3.508     Document Type: Article

References (47)

1. Fratiglioni L, Viitanen M, von-Strauss E, Tontodonati V, Herlitz A, Winblad B. Very old women at highest risk of dementia and Alzheimer's disease: incidence data from the Kungsholmen Project, Stockholm. Neurology 1997;48:132-138.
2. Bachman DL, Wolf PA, Linn R, et al. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology 1992;42:115-119.
3. Rocca WA, Hofman A, Brayne C, et al. Frequency and distribution of Alzheimer's disease in Europe: a collaborative study of 1980-1990 prevalence findings. The EURODEM Prevalence Research Group. Ann Neurol 1991;30:381-390.
4. Mortel KF, Meyer JS, Herod B, Thornby J. Education and occupation as risk factors for dementias of the Alzheimer and ischemic vascular types. Dementia 1995;6:55-62.
5. Payami H, Zareparsi S, Montee KR, et al. Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women. Am J Hum Genet 1996;58:803-811.
6. Siegel BV Jr, Shihabuddin L, Buchsbaum MS, Starr A, Haier RJ, Valladares-Neto DC. Gender differences in cortical glucose metabolism in Alzheimer's disease and normal aging. J Neuropsychiatr Clin Neurosci 1996;8:211-214.
7. Schultz C, Braak H, Braak E. A sex difference in neurodegeneration of the human hypothalamus. Neurosci Lett 1996;212: 103-106.
8. Henderson VW, Buckwalter JG. Cognitive deficits of men and women with Alzheimer's disease. Neurology 1994;44:90-96.
9. Ripich DN, Petrill SA, Whitehouse PJ, Ziol EW. Gender differences in language of AD patients: a longitudinal study. Neurology 1995;45:299-302.
10. Doraiswamy PM, Bieber F, Kaiser L, Krishnan KR, Reuning-Scherer J, Gulanski B. The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials. Neurology 1997;48:1511-1517.
11. Farlow MR, Lahiri DK, Poirier J, Davignon J, Schneider L, Hui SL. Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease. Neurology 1998;50:669-677.
12. Bowen JD, Malter AD, Sheppard L, et al. Predictors of mortality in patients diagnosed with probable Alzheimer's disease. Neurology 1996;47:433-439.
13. Heyman A, Peterson B, Fillenbaum G, Pieper C. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part XIV: Demographic and clinical predictors of survival in patients with Alzheimer's disease. Neurology 1996; 46:656-660.
14. Stern Y, Tang MX, Albert MS, et al. Predicting time to nursing home care and death in individuals with Alzheimer disease. JAMA 1997;277:806-812.
15. Mayeux R. Understanding Alzheimer's disease: expect more genes and other things. Ann Neurol 1996;39:689-690.
16. McEwen BS, Alves SE, Bullock K, Weiland NG. Ovarian steroids and the brain: implications for cognition and aging. Neurology 1997;48:S8-S15.
17. Landi F, Gambassi G, Lapane KL, Sgadari A, Mor V, Bernabei R. Impact of type and severity of dementia on hospitalization and survival of elderly people. Dement Geriatr Cogn Disord 1999;10:121-129.
18. Walsh JS, Welch HG, Larson EB. Survival of outpatients with Alzheimer-type dementia. Ann Intern Med 1990;113:429-434.
19. Bernabei R, Gambassi G, Mor V. The SAGE database: introducing functional outcomes in geriatric pharmacoepidemiology. J Am Geriatr Soc 1997;45:250-251.
20. Bernabei R, Gambassi G, Lapane K, et al. Characteristics of the SAGE database: a new resource for research on outcomes in long-term care. J Gerontol Med Sci 1999;54A:M25-M33.
21. Gambassi G, Landi F, Peng L, et al. Validity of diagnostic and drug data in standardized nursing home resident assessments: potential for geriatric pharmacoepidemiology. Med Care 1998;36:167-179.
22. Morris JN, Fries BE, Meher DR, et al. MDS Cognitive Performance Scale. J Gerontol 1994;49:M174-M82.
23. Mor V, Branco K, Fleishman J, et al. The structure of social engagement among nursing home residents. J Gerontol 1995; 50:P1-8.
24. Hartmaier SL, Sloane PD, Guess HA, Koch GC, Mitchell CM, Phillips CD. Validation of the Minimum Data Set Cognitive Performance Scale: agreement with the Mini-Mental State Examination. J Gerontol 1995;50:M128-M133.
25. Landi F, Gambassi G, Lapane K, et al. Comorbidity and drug use in cognitively impaired elderly living in long-term care. Dementia Geriatr Cogn Disord 1998;9:347-356.
26. Gambassi G, Landi F, Lapane K, Sgadari A, Mor V, Bernabei R. Predictors of mortality in patients with Alzheimer's disease living in nursing home. J Neurol Neurosurg Psychiatry 1999 (in press).
27. Gifford DR, Lapane KL, Gambassi G, Landi F, Mor V, Bernabei R. Tacrine use in nursing home. Implications for prescribing new cholinesterase inhibitors. Neurology 1999;52:238-244.
28. Gambassi G, Landi F, Lapane KL, Sgadari A, Mor V, Bernabei R. Is drug use by the elderly with cognitive impairment influenced by type of dementia? Pharmacotherapy 1999;19: 430-436.
29. Buckwalter JG, Sobel E, Dunn ME, Diz MM, Henderson VW. Gender differences on a brief measure of cognitive functioning in Alzheimer's disease. Arch Neurol 1993;50:757-760.
30. Ott BR, Tate CA, Gordon NM, Heindel WC. Gender differences in the behavioral manifestations of Alzheimer's disease. J Am Geriatr Soc 1996;44:583-587.
31. Ryden MB. Aggressive behavior in persons with dementia who live in the community. Alzheimer Dis Assoc Disord 1988; 2:342-355.
32. Aarsland D, Cummings JL, Yenner G, Miller B. Relationship of aggressive behavior to other neuropsychiatric symptoms in patients with Alzheimer's disease. Am J Psychiatry 1996;153: 243-247.
33. Moritz DJ, Fox PJ, Luscombe FA, Kraemer HC. Neurological and psychiatric predictors of mortality in patients with Alzheimer disease in California. Arch Neurol 1997;54:878-885.
34. McGlone J. Sex differences in human asymmetry: a critical survey. Behav Brain Sci 1980;3:215-263.
35. Jost BC, Grossberg GT. The natural history of Alzheimer's disease: a brain bank study. J Am Geriatr Soc 1995;43:1248-1255.
36. Coffey CE, Lucke JF, Saxton JA, et al. Sex differences in brain aging: a quantitative magnetic resonance imaging study. Arch Neurol 1998;55:169-179.
37. Small GW, Kuhl DE, Riege WH, et al. Cerebral glucose metabolic patterns in Alzheimer's disease. Effect of gender and age at dementia onset. Arch Gen Psychiatry 1989;46:527-532.
38. Oxenkrug GF, Gurevich D, Siegel B, Dumlao MS, Gershon S. Correlation between brain-adrenal axis activation and cognitive impairment in Alzheimer's disease: is there a gender effect? Psychiatry Res 1989;29:169-175.
39. Xu H, Gouras GK, Greenfield JP, et al. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med 1998;4:447-451.
40. Lautenschlager NT, Cupples LA, Rao VS, et al. Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study. What is in store for the oldest old? Neurology 1996;46:641-650.
41. Wolf-Klein GP, Silverstone FA, Brod MS, et al. Are Alzheimer patients healthier? J Am Geriatr Soc 1988;36:219-224.
42. Renner EA, Engle VF, Graney MJ. Prevalence and predictors of regularly scheduled prescription medications of newly admitted nursing home residents. J Am Geriatr Soc 1992;40: 232-236.
43. Semla TP, Cohen D, Paveza G, et al. Drug use patterns of persons with Alzheimer's disease and related disorders living in the community. J Am Geriatr Soc 1993;41:408-413.
44. Castle NG, Mor V. Hospitalization of nursing home residents: a review of the literature, 1980-1995. Med Care Res Rev 1996;53:123-148.
45. Fried TR, Mor V. Frailty and hospitalization of long-term stay nursing home residents. J Am Geriatr Soc 1997;45:265-269.
46. Magaziner J, Zimmerman SI, German Ps, et al. Ascertaining dementia by expert panel in epidemiologic studies of nursing home residents. Ann Epidemiol 1996;6:431-437.
47. Bowler JV, Munoz DG, Merskey H, Hachinski V. Fallacies in the pathological confirmation of the diagnosis of Alzheimer's disease. J Neurol Neurosurg Psychiatry 1998;64:18-24.