-
1
-
-
0030707656
-
Structural plasticity in a remodeled protein-protein interface
-
Atwell S., Ultsch M., De Vos A. M., Wells J. A. Structural plasticity in a remodeled protein-protein interface. Science. 278:1997;1125-1128.
-
(1997)
Science
, vol.278
, pp. 1125-1128
-
-
Atwell, S.1
Ultsch, M.2
De Vos, A.M.3
Wells, J.A.4
-
2
-
-
0032479179
-
Anatomy of hot spots in protein interfaces
-
Bogan A. A., Thorn K. S. Anatomy of hot spots in protein interfaces. J. Mol. Biol. 280:1998;1-9.
-
(1998)
J. Mol. Biol.
, vol.280
, pp. 1-9
-
-
Bogan, A.A.1
Thorn, K.S.2
-
3
-
-
0021504608
-
The use of double-mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)
-
Carter P. J., Winter G., Wilkinson A. J., Fersht A. R. The use of double-mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus). Cell. 38:1984;835-840.
-
(1984)
Cell
, vol.38
, pp. 835-840
-
-
Carter, P.J.1
Winter, G.2
Wilkinson, A.J.3
Fersht, A.R.4
-
4
-
-
0028916599
-
A hot spot of binding energy in a hormone-receptor interface
-
Clackson T., Wells J. A. A hot spot of binding energy in a hormone-receptor interface. Science. 267:1995;383-386.
-
(1995)
Science
, vol.267
, pp. 383-386
-
-
Clackson, T.1
Wells, J.A.2
-
5
-
-
0024527223
-
Modeling the polypeptide backbone with "spare parts" from known protein structures
-
Claessens M., Van Cutsem E., Lasters I., Wodak S. Modeling the polypeptide backbone with "spare parts" from known protein structures. Protein Eng. 2:1989;335-345.
-
(1989)
Protein Eng.
, vol.2
, pp. 335-345
-
-
Claessens, M.1
Van Cutsem, E.2
Lasters, I.3
Wodak, S.4
-
6
-
-
0028261051
-
Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?
-
Collen D., Lijnen H. R. Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential? Blood. 84:1994;680-686.
-
(1994)
Blood
, vol.84
, pp. 680-686
-
-
Collen, D.1
Lijnen, H.R.2
-
7
-
-
0027132013
-
Comparison of a structural and a functional epitope
-
Cunningham B. C., Wells J. A. Comparison of a structural and a functional epitope. J. Mol. Biol. 234:1993;554-563.
-
(1993)
J. Mol. Biol.
, vol.234
, pp. 554-563
-
-
Cunningham, B.C.1
Wells, J.A.2
-
8
-
-
0026589733
-
The dead-end elimination theorem and its use in protein side-chain positioning
-
Desmet J., De Maeyer M., Hazes B., Lasters I. The dead-end elimination theorem and its use in protein side-chain positioning. Nature. 356:1992;539-542.
-
(1992)
Nature
, vol.356
, pp. 539-542
-
-
Desmet, J.1
De Maeyer, M.2
Hazes, B.3
Lasters, I.4
-
9
-
-
0023645205
-
Non-additivity in protein-protein interactions
-
Horowitz A. Non-additivity in protein-protein interactions. J. Mol. Biol. 224:1987;733-740.
-
(1987)
J. Mol. Biol.
, vol.224
, pp. 733-740
-
-
Horowitz, A.1
-
10
-
-
0024556150
-
Engineering hybrid genes without the use of restriction enzymes: Gene splicing by overlap extension
-
Horton R. M., Hunt H. D., Ho S. N., Pullen J. K., Pease L. R. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene. 77:1989;61-68.
-
(1989)
Gene
, vol.77
, pp. 61-68
-
-
Horton, R.M.1
Hunt, H.D.2
Ho, S.N.3
Pullen, J.K.4
Pease, L.R.5
-
11
-
-
0024293878
-
Why ion pair reversal by protein engineering is unlikely to succeed
-
Hwang J.-K., Warshel A. Why ion pair reversal by protein engineering is unlikely to succeed. Nature. 334:1988;270-272.
-
(1988)
Nature
, vol.334
, pp. 270-272
-
-
Hwang, J.-K.1
Warshel, A.2
-
12
-
-
0032530751
-
High resolution mapping of the B cell epitopes of staphylokinase in humans using negative selection of a phage-displayed antigen library
-
Jenné S., Brepoels K., Collen D., Jespers L. High resolution mapping of the B cell epitopes of staphylokinase in humans using negative selection of a phage-displayed antigen library. J. Immunol. 161:1998;3161-3168.
-
(1998)
J. Immunol.
, vol.161
, pp. 3161-3168
-
-
Jenné, S.1
Brepoels, K.2
Collen, D.3
Jespers, L.4
-
13
-
-
0031588015
-
Epitope mapping by negative selection of randomized antigen libraries displayed on filamentous phage
-
Jespers L., Jenné S., Lasters I., Collen D. Epitope mapping by negative selection of randomized antigen libraries displayed on filamentous phage. J. Mol. Biol. 269:1997;704-718.
-
(1997)
J. Mol. Biol.
, vol.269
, pp. 704-718
-
-
Jespers, L.1
Jenné, S.2
Lasters, I.3
Collen, D.4
-
14
-
-
0032485885
-
Arginine 719 in human plasminogen mediates formation of the staphylokinase:plasmin activator complex
-
Jespers L., Van Herzeele N., Lijnen H. R., Van Hoef B., De Maeyer M., Collen D., Lasters I. Arginine 719 in human plasminogen mediates formation of the staphylokinase:plasmin activator complex. Biochemistry. 37:1998;6380-6386.
-
(1998)
Biochemistry
, vol.37
, pp. 6380-6386
-
-
Jespers, L.1
Van Herzeele, N.2
Lijnen, H.R.3
Van Hoef, B.4
De Maeyer, M.5
Collen, D.6
Lasters, I.7
-
15
-
-
0026675750
-
High resolution functional analysis of antibody-antigen interactions
-
Jin L., Fendly B. M., Wells J. A. High resolution functional analysis of antibody-antigen interactions. J. Mol. Biol. 226:1992;851-865.
-
(1992)
J. Mol. Biol.
, vol.226
, pp. 851-865
-
-
Jin, L.1
Fendly, B.M.2
Wells, J.A.3
-
16
-
-
0029863608
-
Protein-protein interaction: A genetic selection for compensating mutations at the barnase-barstar interface
-
Jucovic M., Hartley R. W. Protein-protein interaction: a genetic selection for compensating mutations at the barnase-barstar interface. Proc. Natl Acad. Sci. USA. 93:1996;2343-2347.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 2343-2347
-
-
Jucovic, M.1
Hartley, R.W.2
-
17
-
-
0029881007
-
MolMol: A program for display and analysis of macromolecular structures
-
Korasi R., Billeter M., Wuthrich K. MolMol: a program for display and analysis of macromolecular structures. J. Mol. Graph. 14:1996;51-55.
-
(1996)
J. Mol. Graph.
, vol.14
, pp. 51-55
-
-
Korasi, R.1
Billeter, M.2
Wuthrich, K.3
-
18
-
-
0029665065
-
The 2.3 Å crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator
-
Lamba D., Bauer M., Huber R., Fischer S., Rudolph R., Kohnert U., Bode W. The 2.3 Å crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator. J. Mol. Biol. 258:1996;117-135.
-
(1996)
J. Mol. Biol.
, vol.258
, pp. 117-135
-
-
Lamba, D.1
Bauer, M.2
Huber, R.3
Fischer, S.4
Rudolph, R.5
Kohnert, U.6
Bode, W.7
-
19
-
-
0029902763
-
Computational methods for biomolecular docking
-
Lengauer T., Rarey M. Computational methods for biomolecular docking. Curr. Opin. Struct. Biol. 6:1996;402-406.
-
(1996)
Curr. Opin. Struct. Biol.
, vol.6
, pp. 402-406
-
-
Lengauer, T.1
Rarey, M.2
-
20
-
-
0025262153
-
Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740Ala) and plasmin-resistant scu-PA (Lys158Glu)
-
Lijnen H. R., Van Hoef B., Nelles L., Collen D. Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740Ala) and plasmin-resistant scu-PA (Lys158Glu). J. Biol. Chem. 265:1990;5232-5236.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 5232-5236
-
-
Lijnen, H.R.1
Van Hoef, B.2
Nelles, L.3
Collen, D.4
-
21
-
-
0025949188
-
On the mechanism of fibrin-specific plasminogen activation by staphylokinase
-
Lijnen H. R., Van Hoef B., De Cock F., Okada K., Ueshima S., Matsuo O., Collen D. On the mechanism of fibrin-specific plasminogen activation by staphylokinase. J. Biol. Chem. 266:1991;11826-11832.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 11826-11832
-
-
Lijnen, H.R.1
Van Hoef, B.2
De Cock, F.3
Okada, K.4
Ueshima, S.5
Matsuo, O.6
Collen, D.7
-
22
-
-
0027982294
-
Characterization of the interaction between plasminogen and staphylokinase
-
Lijnen H. R., De Cock F., Van Hoef B., Schlott B., Collen D. Characterization of the interaction between plasminogen and staphylokinase. Eur. J. Biochem. 224:1994;143-149.
-
(1994)
Eur. J. Biochem.
, vol.224
, pp. 143-149
-
-
Lijnen, H.R.1
De Cock, F.2
Van Hoef, B.3
Schlott, B.4
Collen, D.5
-
23
-
-
0031172764
-
Screening panels of monoclonal antibodies using phage-displayed antigen
-
Lijnen H. R., Lasters I., Verstreken M., Collen D., Jespers L. Screening panels of monoclonal antibodies using phage-displayed antigen. Anal. Biochem. 248:1997;211-215.
-
(1997)
Anal. Biochem.
, vol.248
, pp. 211-215
-
-
Lijnen, H.R.1
Lasters, I.2
Verstreken, M.3
Collen, D.4
Jespers, L.5
-
25
-
-
0025597970
-
Restoration of serine protease inhibitor interaction by protein engineering
-
Madison E. L., Goldsmith E. J., Gething M. J., Sambrook J. F., Gerard R. D. Restoration of serine protease inhibitor interaction by protein engineering. J. Biol. Chem. 265:1990;21423-21426.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 21423-21426
-
-
Madison, E.L.1
Goldsmith, E.J.2
Gething, M.J.3
Sambrook, J.F.4
Gerard, R.D.5
-
26
-
-
0032530717
-
VEGF and the Fab fragment of a humanized neutralizing antibody: Crystal structure of the complex at 2.4 Å resolution and mutational analysis of the interface
-
Muller Y. A., Chen Y., Christinger H. W., Li B., Cunningham B., Lowman H. B., de Vos A. M. VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 Å resolution and mutational analysis of the interface. Structure. 6:1998;1153-1167.
-
(1998)
Structure
, vol.6
, pp. 1153-1167
-
-
Muller, Y.A.1
Chen, Y.2
Christinger, H.W.3
Li, B.4
Cunningham, B.5
Lowman, H.B.6
De Vos, A.M.7
-
27
-
-
0031596034
-
The ternary microplasmin- staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action
-
Parry M. A. A., Fernandez-Catala C., Bergner A., Huber R., Hopfner K. P., Schlott B., Gührs K. H., Bode W. The ternary microplasmin- staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action. Nature Struct. Biol. 5:1998;917-923.
-
(1998)
Nature Struct. Biol.
, vol.5
, pp. 917-923
-
-
Parry, M.A.A.1
Fernandez-Catala, C.2
Bergner, A.3
Huber, R.4
Hopfner, K.P.5
Schlott, B.6
Gührs, K.H.7
Bode, W.8
-
28
-
-
0029794909
-
Structural and functional analysis of affinity-inert contact residues at the growth hormone-receptor interface
-
Pearce K. H., Ultsch M. H., Kelley R. F., De Vos A. M., Wells J. A. Structural and functional analysis of affinity-inert contact residues at the growth hormone-receptor interface. Biochemistry. 35:1996;10300-10307.
-
(1996)
Biochemistry
, vol.35
, pp. 10300-10307
-
-
Pearce, K.H.1
Ultsch, M.H.2
Kelley, R.F.3
De Vos, A.M.4
Wells, J.A.5
-
29
-
-
0030888405
-
Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential
-
Rabijns A., De Bondt H., De Ranter C. Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential. Nature Struct. Biol. 4:1997;357-360.
-
(1997)
Nature Struct. Biol.
, vol.4
, pp. 357-360
-
-
Rabijns, A.1
De Bondt, H.2
De Ranter, C.3
-
30
-
-
0027957844
-
High yield production and purification of recombinant staphylokinase for thrombolytic therapy
-
Schlott B., Hartmann M., Gührs E., Birch-Hirschfeld H., Pohl S., Vanderschueren S., Van de Werf F., Michoel A., Collen D., Behnke D. High yield production and purification of recombinant staphylokinase for thrombolytic therapy. Biotechnology. 12:1994;185-189.
-
(1994)
Biotechnology
, vol.12
, pp. 185-189
-
-
Schlott, B.1
Hartmann, M.2
Gührs, E.3
Birch-Hirschfeld, H.4
Pohl, S.5
Vanderschueren, S.6
Van De Werf, F.7
Michoel, A.8
Collen, D.9
Behnke, D.10
-
31
-
-
0029056922
-
Energetics of protein-protein interactions: Analysis of the barnase-barstar interface by single mutations and double-mutant cycles
-
Schreiber G., Fersht A. Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double-mutant cycles. J. Mol. Biol. 248:1995;478-486.
-
(1995)
J. Mol. Biol.
, vol.248
, pp. 478-486
-
-
Schreiber, G.1
Fersht, A.2
-
32
-
-
0016160429
-
Measurement of protein by spectrophotometry at 205 nm
-
Scopes R. K. Measurement of protein by spectrophotometry at 205 nm. Anal. Biochem. 59:1974;277-282.
-
(1974)
Anal. Biochem.
, vol.59
, pp. 277-282
-
-
Scopes, R.K.1
-
33
-
-
0027299571
-
Interaction between staphylokinase, plasmin(ogen), and alpha 2-antiplasmin. Recycling staphylokinase after neutralization of the plasmin-staphylokinase complex by alpha 2-antiplasmin
-
Silence K., Collen D., Lijnen H. R. Interaction between staphylokinase, plasmin(ogen), and alpha 2-antiplasmin. Recycling staphylokinase after neutralization of the plasmin-staphylokinase complex by alpha 2-antiplasmin. J. Biol. Chem. 268:1993;9811-9816.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 9811-9816
-
-
Silence, K.1
Collen, D.2
Lijnen, H.R.3
-
34
-
-
0028785331
-
Structure-function relationships in staphylokinase revealed by "clustered charge to alanine" mutagenesis
-
Silence K., Hartmann M., Gührs K. H., Gase A., Schlott B., Collen D., Lijnen H. R. Structure-function relationships in staphylokinase revealed by "clustered charge to alanine" mutagenesis. J. Biol. Chem. 270:1995;27192-27198.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27192-27198
-
-
Silence, K.1
Hartmann, M.2
Gührs, K.H.3
Gase, A.4
Schlott, B.5
Collen, D.6
Lijnen, H.R.7
-
35
-
-
0026350498
-
Systematic mutational analyses of protein-protein interfaces
-
Wells J. A. Systematic mutational analyses of protein-protein interfaces. Methods Enzymol. 202:1991;390-411.
-
(1991)
Methods Enzymol.
, vol.202
, pp. 390-411
-
-
Wells, J.A.1
|