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Volumn 9, Issue 23, 1999, Pages 3267-3272

Blockers of human T cell KV1.3 potassium channels using de novo ligand design and solid-phase parallel combinatorial chemistry

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 1,4 DIHYDRO 4 PENTYLIMINOQUINOLINE; CHARYBDOTOXIN; CP 394322; IMMUNOSUPPRESSIVE AGENT; LIGAND; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

EID: 0033530862     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00601-0     Document Type: Article
Times cited : (21)

References (31)
  • 17
    • 0032478818 scopus 로고    scopus 로고
    • + channel, the KcSA channel has been published. A refined model of the Kv1.3 channel currently serves as the basis for our continued studies
    • + channel, the KcSA channel has been published: Doyle, D. A.; Cabral, J. M.; Pfuetzner, R. A.; Kuo, A.; Gulbis, J. M.; Cohen, S. L.; Chait, B. T.; MacKinnon, R. Science 1998, 280, 69. A refined model of the Kv1.3 channel currently serves as the basis for our continued studies.
    • (1998) Science , vol.280 , pp. 69
    • Doyle, D.A.1    Cabral, J.M.2    Pfuetzner, R.A.3    Kuo, A.4    Gulbis, J.M.5    Cohen, S.L.6    Chait, B.T.7    MacKinnon, R.8
  • 20
    • 85038137616 scopus 로고    scopus 로고
    • note
    • Low energy conformers of the phenyl stilbene molecules were identified using the MM2* forcefield in Macromodel 5.5. Molecules within 5.0 KJ of the global minimum were used to make a LUDI library of low energy conformers of the scaffold.
  • 31
    • 85038136095 scopus 로고    scopus 로고
    • note
    • 50 values for the substituted phenyl stilbenes were determined by Dean Synder of Zeneca Pharmaceuticals.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.