Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 6, 1999, Pages 835-840

  Plummer, Janet S ^a   Berryman, Kent A ^a   Cuiman, Cai ^a   Cody, Wayne L ^a   DiMaio, John ^a,b   Doherty, Annette M ^a   Eaton, Scott ^a   Edmunds, Jeremy J ^a   Holland, Debra R ^a   Lafleur, D ^a,b   Levesque, Sophie ^a,b   Narasimhan, Lakshmi S ^a   Rubin, J Ronald ^a   Rapundalo, Stephen T ^a   Siddiqui, M Arshad ^a,b   Susser, A ^a   St Denis, Yves ^a,b   Winocour, Peter ^a,b  

^a PFIZER INC   (United States)

^b Shire Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN ANTICOAGULANT; HIRUDIN; HIRULOG; THROMBIN; THROMBIN INHIBITOR; TRYPSIN;

ARTICLE; BLOOD CLOTTING; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; DISEASE MODELS, ANIMAL; HETEROCYCLIC COMPOUNDS; INHIBITORY CONCENTRATION 50; KINETICS; LACTAMS; MODELS, CHEMICAL; MODELS, MOLECULAR; RATS; THROMBIN; THROMBOSIS;

EID: 0033594159     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00096-7     Document Type: Article

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