Potent and selective bicyclic lactam inhibitors of thrombin: Part 2:P1 modifications

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 23, 1998, Pages 3409-3414

  Plummer, Janet S ^a   Berryman, Kent A ^a   Cai, Cuiman ^a   Cody, Wayne L ^a   Dimaio, John ^b   Doherty, Annette M ^a   Edmunds, Jeremy J ^a   He, John X ^a   Holland, Debra R ^a   Levesque, Sophie ^b   Kent, Darin R ^a   Narasimhan, Lakshmi S ^a   Rubin, J Ronald ^a   Rapundalo, Stephen T ^a   Siddiqui, M Arshad ^b   Susser, Alan J ^a   St Denis, Yves ^b   Winocour, Peter D ^b  

^a PFIZER INC   (United States)

^b Shire Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN; HEPARIN; HIRUDIN; HIRULOG; THROMBIN INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; DRUG CONFORMATION; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; THROMBOSIS PREVENTION;

EID: 0032402457     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00613-1     Document Type: Article

References (19)

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