Effectiveness of ipsapirone, a 5-HT-1A partial agonist, in major depressive disorder: Support for the role of 5-HT-1A receptors in the mechanism of action of serotonergic antidepressants

International Journal of Neuropsychopharmacology

Volumn 1, Issue 1, 1998, Pages 11-18

  Stahl, Stephen M ^a   Kaiser, Lee ^b   Roeschen, Julie ^b   Hesselink, Jan M Keppel ^c   Orazem, John ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BAYER CORPORATION   (United States)

^c BAYER AG   (Germany)

Author keywords

5 HT 1A receptor agonist; Azapirone; Depression; Ipsapirone; Serotonin

Indexed keywords

EID: 0002724511     PISSN: 14611457     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1461145798001059     Document Type: Article

References (27)

1. American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders (3rd ed., revised) Washington DC: American Psychiatric Association.
2. Blier P, deMontigny C, Chaput Y (1987). Modifications of the serotonin system by anti depressant treatment: implications for the therapeutic response in major depression Journal of Clinical Psychopharmacology 7 (Supplement), 24S-35S.
3. Blier P, Lista A, deMontigny C (1993). Differential properties of pre- and post-synaptic 5-hydroxytryptamine 1A receptors: I. Effect of spiperone. Journal of and Experimental Therapeutics 265, 16-23.
4. Cohn JB, Rickels K, Steege JF (1989). A pooled double-blind comparison of the effects of buspirone, diazepam and placebo in women with chronic anxiety. Current Medical Research and Opinion 11, 304-320.
5. Csanalosi I, Schweizer E, Case WG, Rickels K (1987). Gepirone in anxiety: a pilot study. Journal of Clinical Psychopharmacology 7, 31-33.
6. 1A agonists: animal models of anxiety and depression. In: Stahl SM, Gastpar M, Keppel Hesselink JM, Traber J (Eds.), Serotonin 1A Receptors in Depression and Anxiety (pp. 55-81) New York: Raven Press.
7. Fabre LF Jr. (1990). Buspirone in the management of major depression: a placebo-controlled comparison. Journal of Clinical Psychiatry 51, 9 (Supplement) 55-61.
8. Feigner J, Merideth CH, Hendrickson GA (1982). A double-blind comparison of buspirone and diazepam in outpatients with generalized anxiety disorder. Journal of Clinical Psychiatry 43 (12, sec. 2), 103-107.
9. Gammans RE, Stingfellow JC, Hvizdos AJ et al. (1992). Use of buspirone in patients with generalized anxiety disorder and coexisting depressive symptoms: a meta analysis of eight randomized, controlled studies. Neuropsychobiology 25 (4), 193-201.
10. Goldberg HL, Finnerty RJ (1979). The comparative efficacy of buspirone and diazepam in the treatment of anxiety. American Journal of Psychiatry 136, 1184-1187.
11. Harto N, Branconnier RJ (1988). Clinical profile of gepirone: a nonbenzodiazepine anxiolytic. Psychopharmacological Bulletin 24, 154-160.
12. Heller AH, Beneke M, Kuemmel B, Spencer D, Kurtz NM (1990). Ipsapirone: evidence for efficacy in depression. Psychopharmacological Bulletin 26 (2), 219-222.
13. Jenkins SW, Robinson DS, Fabre LF Jr., Andary JJ, Messina ME, Reich LA (1990). Gepirone in the treatment of major depression. Journal of Clinical Psychopharmacology 10 (3) (Supplement), 77S-85S.
14. Keppel Hesselink JM (1992). Promising anxiolytics? A new class of drugs: the azapirones. In: Stahl SM, Gastpar M, Keppel Hesselink JM, Traber J (Eds.), Serotonin 1A Receptors in Depression and Anxiety (pp. 171-183) New York: Raven Press.
15. Kurtz N (1992). Efficacy of azapirones in depression. In: Stahl SM, Gastpar M, Keppel Hesselink JM and Traber J (Eds.), Serotonin 1A Receptors in Depression and Anxiety (pp. 163-170). New York: Raven Press.
16. Pollard GT, Howard JL (1990). Effects of drugs on punished behavior: pre-clinical test or anxiolytics. Pharmacology and Therapeutics 45, 403-424.
17. Rickels K, Weissman K, Norstad N et al (1982). Buspirone and diazepam in anxiety: a controlled study. Journal of Clinical Psychiatry 43 (12, sec 2), 81-86.
18. Robinson DS, Alms DR, Shrotriya RC, Messina M, Wickramaratne P (1989). Serotonergic anxiolytics and treatment of depression. Psychopathology 22 (Supplement 1), 27-36.
19. 1A partial agonist drugs. In: Sandler M, Coppen A, Harnett S (Eds.), 5-Hydroxytryptamine in Psychiatry (pp. 157-165) Oxford: Oxford University Press.
20. Sramek JJ, Tansman M, Suri A, Hornig-Rohan M, Amsterdam JD, Stahl SM, Weisler RH, Cutler NR (1996). Efficacy of buspirone in generalized anxiety disorder with co-existing mild depressive symptoms. Journal of Clinical Psychiatry 57 (7), 287-291.
21. Stahl SM, Gastpar M, Keppel Hesselink JM, Traber J (Eds.), (1992). Serotonin 1A Receptors in Depression and Anxiety. New York: Raven Press.
22. Stahl, SM (1992). Serotonin receptors and the mechanism of action of antidepressant drugs: postmortem, platelet and neuroendocrine studies in depressed patients. In: Stahl SM, Gastpar M, Keppel Hesselink JM, Traber J. (Eds), Serotonin 1A Receptors in Depression and Anxiety (pp. 119-134). New York: Raven Press.
23. Stahl SM (1994). Is serotonin receptor down-regulation linked to the mechanism of action of antidepressant drugs? Psychopharmacological Bulletin 30 (1), 39-43.
24. Stahl SM (1996). Essential Psychopharmacology. New York: Cambridge University Press.
25. Stahl SM (In Press) Mechanism of action of serotonin selective re-uptake inhibitors: serotonin receptors and pathways mediate therapeutic effects and side-effects. Journal of Affective Disorders.
26. 1A-sensitive adenylyl cyclase of rodent hippocampal neurons: effects of antidepressant treatments and chronic stimulation with agonists. Journal of Pharmacology and Experimental Therapeutics 257 (1), 433-438.
27. Wieland S, Fischette CT, Luck I (1993). Effect of chronic treatments with tandospirone and imipramine on serotonin-mediated behavioral responses and monoamine receptors. Neuropharmacology 32 (6), 561-573.