Central effect of SNC 80, a selective and systemically active δ-opioid receptor agonist, on gastrointestinal propulsion in the mouse

European Journal of Pharmacology

Volumn 342, Issue 2-3, 1998, Pages 247-251

  Broccardo, Maria ^a   Improta, Giovanna ^a   Tabacco, Alessandra ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Opioid receptor agonist; (Mouse); Colonic propulsion; Gastrointestinal transit; Peripheral administration

Indexed keywords

17 METHYLNALOXONE; 4 [(4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; BENZAMIDE DERIVATIVE; CHARCOAL; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; NALOXONAZINE; NALOXONE; NALTRINDOLE; OPIATE AGONIST; OPIATE ANTAGONIST; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COLON MOTILITY; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BENZAMIDES; CENTRAL NERVOUS SYSTEM; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; GASTROINTESTINAL MOTILITY; INJECTIONS, INTRAPERITONEAL; MALE; MICE; NARCOTIC ANTAGONISTS; PIPERAZINES; RECEPTORS, OPIOID, DELTA; RECEPTORS, SIGMA;

EID: 0032567707     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01470-2     Document Type: Article

References (28)

1. Bilsky E.J., Calderon S.N., Wang T., Bernstein R.N., Davis P., Hruby V.J., McNutt R.W., Rothman R.B., Rice K.C., Porreca F. SNC 80, a selective, non-peptidic and systemically active opioid delta agonist. J. Pharmacol. Exp. Ther. 273:1995;359-366.
2. 2) deltorphin II, in the rat. Eur. J. Pharmacol. 218:1992;69-73.
3. 2-deltorphin II, a selective delta opioid agonist, in the mouse. Pharmacol. Res. 25:1992;275-276.
4. Broccardo M., Improta G., Nargi M., Melchiorri P. Effects of dermorphin on gastrointestinal transit in rats. Reg. Peptides. 4:1982;91-96.
5. Burks T.F., Fox D.A., Hirning L.D., Shook J.E., Porreca F. Regulation of gastrointestinal function by multiple opioid receptors. Life Sci. 43:1988;2177-2181.
6. Calderon S.N., Rothman R.B., Porreca F., Flippen-Anderson J.L., McNutt R.W., Xu H., Smith L.E., Bilsky E.J., Davis P., Rice K.C. Probes for narcotic receptor mediated phenoma. 191 Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A highly selective, nonpeptide δ opioid receptor agonist. J. Med. Chem. 37:1994;2125-2128.
7. Cha X.Y., Xu H., Rice K.C., Porreca F., Lai J., Ananthans S., Rothman R.B. Opioid peptide receptor studies. 1. Identification of a novel delta-opioid receptor binding site in rat brain membranes. Peptides. 16:1995;191-198.
8. Galligan J.J., Burks T.F. Centrally mediated inhibition of small intestinal transit and motility by morphine in the rat. J. Pharmacol. Exp. Ther. 226:1983;356-361.
9. Galligan J.J., Mosberg H.I., Hurst R., Hruby V.J., Burks T.F. Cerebral delta opioid receptors mediate analgesia but not the intestinal motility effects of intracerebroventricularly administered opioids. J. Pharmacol. Exp. Ther. 229:1984;641-648.
10. Heyman J.S., Williams C.L., Burks T., Mosberg H.J., Porreca F. Dissociation of opioid antinociception and central gastrointestinal propulsion in the mouse: Studies with naloxonazine. J. Pharmacol. Exp. Ther. 245:1988;238-243.
11. Improta G., Broccardo M. Effects of selective mu1, mu2 and delta2 opioid receptor agonists on gastric functions in the rat. Neuropharmacology. 33:1994;977-981.
12. Jacoby H.I., Lopez I. A method for the evaluation of colonic propulsive motility in the mouse after i.c.v. administered compounds. Dig. Dis. Sci. 29:1984;551.
13. Kaufman P.N., Krevsky B., Malmud L.S., Maurer A.H., Somers M.B., Siegel J.A., Fisher R.S. Role of opiate receptors in the regulation of colonic transit. Gastroenterology. 94:1988;1351-1359.
14. Knapp R.J., Santoro G., De Leon I., Lee K.B., Edsall S.A., Waite S., Malatynska E., Varga E., Calderon S.N., Rice K.C., Rothman R.B., Porreca F., Roeske W.R., Yamamura H.I. Structure-activity relationships for SNC 80 and related compounds at cloned human delta and mu opioid receptors. J. Pharmacol. Exp. Ther. 277:1996;1284-1291.
15. Krevsky B., Cowan A., Maurer A.H., Butt W., Fisher R.S. Effects of selective opioid agonists on feline colonic transit. Life Sci. 48:1991;1597-1602.
16. Ling S.F., Simantou R., Clark J.A., Pasternak G.W. Naloxonazine actions in vivo. Eur. J. Pharmacol. 129:1986;33-38.
17. Lord J.A.H., Waterfield A.A., Hughes J., Kosterlitz H.W. Endogenous opioid peptides: Multiple agonists and receptors. Nature. 267:1977;495-499.
18. Magnam J., Paterson S.J., Tavani A., Kosterlitz H.W. The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties. N.S. Arch. Pharmacol. 319:1982;197-205.
19. Manara L., Bianchetti A. The central and peripheral influences of opioids on gastrointestinal propulsion. Ann. Rev. Pharmacol. Toxicol. 25:1985;249-273.
20. 3H ]-SNC 80. 27th Meeting of the International Narcotics Research Conference. Long Beach, California, July 21 to 26, Abstr., p. 67.
21. Milne R.J., Coddington J.M., Gamble G.D. Quaternary naloxone blocks morphine analgesia in spinal but not intact rats. Neurosci. Lett. 114:1990;259-264.
22. Porreca F., Mosberg H.I., Hurst R., Hruby V.J., Burks T.F. Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse. J. Pharmacol. Exp. Ther. 230:1984;341-348.
23. Porreca F., Galligan J.J., Burks T.F. Central opioid receptor involvement in gastrointestinal motility. TIPS. 7:1986;104-107.
24. Portoghese P.S., Sultana M., Takemori A.E. Naltrindole, a highly selective and potent, non-peptide delta opioid receptor antagonist. Eur. J. Pharmacol. 146:1988;185-190.
25. Raffa R.B., Mathiasen J.R., Jacoby H.I. Colonic bead expulsion time in normal and mu-opioid receptor deficient (CXBK) mice following central administration of mu- and delta agonists. Life Sci. 41:1987;2229-2234.
26. Rapaka R.S., Porreca F. Development of delta opioid peptides as nonaddicting analgesics. Pharmacol. Res. 8:1991;1-8.
27. Schulz R., Wuster M., Herz A. Centrally and peripherally mediated inhibition of intestinal motility by opioids. N.S. Arch. Pharmacol. 308:1979;255-260.
28. Sheldon R.J., Riviere P.J., Malarchik M.E., Mosberg H.I., Burks T.F., Porreca F. Opioid regulation of mucosal ion transport in the mouse isolated jejunum. J. Pharmacol. Exp. Ther. 253:1990;144-151.