메뉴 건너뛰기




Volumn 9, Issue 4, 1999, Pages 390-395

Cell polarity in the early Caenorhabditis elegans embryo

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS; CELL DIVISION; CELL POLARITY; EMBRYO DEVELOPMENT; MITOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0033523288     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(99)80059-8     Document Type: Article
Times cited : (45)

References (43)
  • 1
    • 0001692568 scopus 로고    scopus 로고
    • Developmental genetics of the germ line
    • Edited by Riddle D, Blumenthal T, Meyer B, Preiss JR. Cold Spring Harbor, NY: Cold Spring Harbor Press
    • Schedl T: Developmental genetics of the germ line. In C. Elegans //. Edited by Riddle D, Blumenthal T, Meyer B, Preiss JR. Cold Spring Harbor, NY: Cold Spring Harbor Press; 1997:241-270.
    • (1997) C. Elegans , pp. 241-270
    • Schedl, T.1
  • 2
    • 0029996765 scopus 로고    scopus 로고
    • Specification of the anteroposterior axis in Caenorhabditis elegans
    • Goldstein B, Hird SN: Specification of the anteroposterior axis in Caenorhabditis elegans. Development 1996, 122:1467-1474.
    • (1996) Development , vol.122 , pp. 1467-1474
    • Goldstein, B.1    Hird, S.N.2
  • 3
    • 0027154850 scopus 로고
    • Cortical and cytoplasmic flow polarity in early embryonic cells of Caenorhabditis elegans
    • Hird SN, White JG: Cortical and cytoplasmic flow polarity in early embryonic cells of Caenorhabditis elegans. J Cell Biol 1993, 121:1343-1355.
    • (1993) J Cell Biol , vol.121 , pp. 1343-1355
    • Hird, S.N.1    White, J.G.2
  • 4
    • 0029880495 scopus 로고    scopus 로고
    • Segregation of germ granules in living Caenorhabditis elegans embryos: Cell-type-specific mechanisms for cytoplasmic localization
    • Hird SN, Paulsen JE, Strome S: Segregation of germ granules in living Caenorhabditis elegans embryos: Cell-type-specific mechanisms for cytoplasmic localization. Development 1996, 122:1303-1312.
    • (1996) Development , vol.122 , pp. 1303-1312
    • Hird, S.N.1    Paulsen, J.E.2    Strome, S.3
  • 5
    • 0030592578 scopus 로고    scopus 로고
    • The maternal gene mex-3 encodes a KH domain protein and regulates blastomere identity in early C. elegans embryos
    • Draper BW, Mello CC, Bowerman B, Hardin J, Priess JR: The maternal gene mex-3 encodes a KH domain protein and regulates blastomere identity in early C. elegans embryos. Cell 1996, 87:205-216.
    • (1996) Cell , vol.87 , pp. 205-216
    • Draper, B.W.1    Mello, C.C.2    Bowerman, B.3    Hardin, J.4    Priess, J.R.5
  • 6
    • 0031056262 scopus 로고    scopus 로고
    • The C. elegans MEX-1 protein is present in germline blastomeres and is a P granule component
    • Guedes S, Priess JR: The C. elegans MEX-1 protein is present in germline blastomeres and is a P granule component. Development 1996, 124:731-739.
    • (1996) Development , vol.124 , pp. 731-739
    • Guedes, S.1    Priess, J.R.2
  • 8
    • 0032483543 scopus 로고    scopus 로고
    • PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans
    • Kawasaki I, Shim Y-H, Kirchner J, Kaminker J, Wood WB, Strome S: PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans. Cell 1998, 94:635-645. The gene pgl-1 encodes a predicted RNA-binding component of P granules that results in sterility when eliminated by mutation. This paper provides the most specific genetic evidence yet that P granules contain germline determinants, accounting at least in part for their segregation to the germline during early embryonic cleavages. As P granules are known to contain polyadenylated RNAs, it is interesting that PES-1 is a predicted RNA-binding protein.
    • (1998) Cell , vol.94 , pp. 635-645
    • Kawasaki, I.1    Shim, Y.-H.2    Kirchner, J.3    Kaminker, J.4    Wood, W.B.5    Strome, S.6
  • 9
    • 0023928785 scopus 로고
    • An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in Caenorhabditis elegans zygotes
    • Hill DP, Strome S: An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in Caenorhabditis elegans zygotes. Dev Biol 1988, 125:75-84.
    • (1988) Dev Biol , vol.125 , pp. 75-84
    • Hill, D.P.1    Strome, S.2
  • 10
    • 0025129162 scopus 로고
    • Brief cytochalasin-induced disruption of microfilaments during a critical interval in 1-cell C. elegans embryos alters the partitioning of developmental instructions to the 2-cell embryo
    • Hill DP, Strome S: Brief cytochalasin-induced disruption of microfilaments during a critical interval in 1-cell C. elegans embryos alters the partitioning of developmental instructions to the 2-cell embryo. Development 1990, 108:159-172.
    • (1990) Development , vol.108 , pp. 159-172
    • Hill, D.P.1    Strome, S.2
  • 11
    • 0030025958 scopus 로고    scopus 로고
    • A sperm-supplied factor required for embryogenesis in C. elegans
    • Browning H, Strome S: A sperm-supplied factor required for embryogenesis in C. elegans. Development 1996, 122:391-404.
    • (1996) Development , vol.122 , pp. 391-404
    • Browning, H.1    Strome, S.2
  • 12
    • 0032426346 scopus 로고    scopus 로고
    • Early patterning of the C. elegans embryo
    • Rose LS, Kemphues KJ: Early patterning of the C. elegans embryo. Annu Rev Genet 1998, 32:521-545.
    • (1998) Annu Rev Genet , vol.32 , pp. 521-545
    • Rose, L.S.1    Kemphues, K.J.2
  • 13
    • 0030969575 scopus 로고    scopus 로고
    • Mark, a novel familiy of protein kinases that phosphoylate microtubule-associated proteins and trigger microtubule disruption
    • Drewes G, Ebneth A, Preuss E, Mandelkow EM, Mandelkow E: Mark, a novel familiy of protein kinases that phosphoylate microtubule-associated proteins and trigger microtubule disruption. Cell 1997, 89:297-308.
    • (1997) Cell , vol.89 , pp. 297-308
    • Drewes, G.1    Ebneth, A.2    Preuss, E.3    Mandelkow, E.M.4    Mandelkow, E.5
  • 14
    • 0031213571 scopus 로고    scopus 로고
    • Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity
    • Bohm H, Brinkmann V, Drab M, Henske A, Kurzchalia TV: Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity. Curr Biol 1997, 7:603-606.
    • (1997) Curr Biol , vol.7 , pp. 603-606
    • Bohm, H.1    Brinkmann, V.2    Drab, M.3    Henske, A.4    Kurzchalia, T.V.5
  • 15
    • 0032487494 scopus 로고    scopus 로고
    • An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3
    • Izumi Y, Hirose T, Tamai Y, Hirai SI, Nagashima Y, Fujimoto T, Tabuse Y, Kemphues KJ, Ohno S: An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J Cell Biol 1998, 143:95-106. The authors report the identification of ASIP, a mammalian homolog of PAR-3 that binds an atypical protein kinase C. ASIP and the atypical protein kinase colocalize with the tight junction protein Z0-1 in cultured epithelial cells, suggesting a potential role in the regulation of apical-basal polarity. As with ASIP and PAR-3, the tight junction protein Z0-1 contains three PDZ domains, although ASIP and PAR-3 differ in having interaction domains for atypical protein kinase C.
    • (1998) J Cell Biol , vol.143 , pp. 95-106
    • Izumi, Y.1    Hirose, T.2    Tamai, Y.3    Hirai, S.I.4    Nagashima, Y.5    Fujimoto, T.6    Tabuse, Y.7    Kemphues, K.J.8    Ohno, S.9
  • 16
    • 0031964706 scopus 로고    scopus 로고
    • Structure, expression and properties of an atypical protein kinase C (PKC3) from Caenorhabditis elegans
    • See annotation [17•]
    • Wu S-L, Staudinger J, Olson EN, Rubin CS: Structure, expression and properties of an atypical protein kinase C (PKC3) from Caenorhabditis elegans. J Biol Chem 1998, 273:1130-1143. See annotation [17•].
    • (1998) J Biol Chem , vol.273 , pp. 1130-1143
    • Wu, S.-L.1    Staudinger, J.2    Olson, E.N.3    Rubin, C.S.4
  • 17
    • 0031674842 scopus 로고    scopus 로고
    • Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans
    • Tabuse Y, Izumi Y, Piano F, Kemphues KJ, Miwa J, Ohno S: Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. Development 1998, 125:3607-3614. These two papers [16•,17•] report the identification of an atypical protein kinase C homolog in C. elegans called pkc-3 and describe its polarized co-localization with PAR-3 at the anterior cortex of single-cell stage embryos. Tabuse and co-workers here use RNA interference to demonstrate that reducing pkc-3 function results in a phenotype similar to those of par-3 and par-6 mutant embryos. Reducing the function of any one gene results in a loss of cortical localization for the other two proteins, suggesting that they act as a complex.
    • (1998) Development , vol.125 , pp. 3607-3614
    • Tabuse, Y.1    Izumi, Y.2    Piano, F.3    Kemphues, K.J.4    Miwa, J.5    Ohno, S.6
  • 18
    • 0020858899 scopus 로고
    • The embryonic cell lineage of the nematode Caenorhabditis elegans
    • Sulston JE, Schierenberg E, White JG, Thomson JN: The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 1983, 100:64-119.
    • (1983) Dev Biol , vol.100 , pp. 64-119
    • Sulston, J.E.1    Schierenberg, E.2    White, J.G.3    Thomson, J.N.4
  • 19
    • 0021064382 scopus 로고
    • Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos
    • Strome S, Wood WB: Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos. Cell 1983, 35:15-25.
    • (1983) Cell , vol.35 , pp. 15-25
    • Strome, S.1    Wood, W.B.2
  • 20
    • 0032949091 scopus 로고    scopus 로고
    • PAR-6 is a conserved PDZ domain containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos
    • Hung T-J, Kemphues KJ: PAR-6 is a conserved PDZ domain containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos. Development 1999, 126:127-135. This paper reports the latest molecular identification of a par gene, leaving unknown only par-5. PAR-6 contains a single PDZ domain and co-localizes with PAR-3 (with its three PDZ domains) to the cytoplasmic cortex at the anterior end of the 1-cell stage embryo. This localization pattern is reiterated in other germline precursors.
    • (1999) Development , vol.126 , pp. 127-135
    • Hung, T.-J.1    Kemphues, K.J.2
  • 21
    • 0026773728 scopus 로고
    • Par-4, a gene required for cytoplasmic localization and determination of specific cell types in Caenorhabditis elegans embryogenesis
    • Morton DG, Roos JM, Kemphues KJ: Par-4, a gene required for cytoplasmic localization and determination of specific cell types in Caenorhabditis elegans embryogenesis. Genetics 1992, 130:771-790.
    • (1992) Genetics , vol.130 , pp. 771-790
    • Morton, D.G.1    Roos, J.M.2    Kemphues, K.J.3
  • 22
    • 0023388004 scopus 로고
    • Reversal of cellular polarity and early cell-cell interaction in the embryo of Caenorhabditis elegans
    • Schierenberg E: Reversal of cellular polarity and early cell-cell interaction in the embryo of Caenorhabditis elegans. Dev Biol 1987, 122:452-463.
    • (1987) Dev Biol , vol.122 , pp. 452-463
    • Schierenberg, E.1
  • 23
    • 0029026861 scopus 로고
    • Cell contacts orient some cell division axes in the Caenorhabditis elegans embryo
    • Goldstein B: Cell contacts orient some cell division axes in the Caenorhabditis elegans embryo. J Cell Biol 1995, 129:1071-1080.
    • (1995) J Cell Biol , vol.129 , pp. 1071-1080
    • Goldstein, B.1
  • 24
    • 0028918437 scopus 로고
    • An analysis of the response to gut induction in the C. elegans embryo
    • Goldstein B: An analysis of the response to gut induction in the C. elegans embryo. Development 1995, 121:1221-1236.
    • (1995) Development , vol.121 , pp. 1221-1236
    • Goldstein, B.1
  • 25
    • 0028783457 scopus 로고
    • Pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos
    • Lin R, Thompson S, Priess JR: Pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos. Cell 1995, 83:599-609.
    • (1995) Cell , vol.83 , pp. 599-609
    • Lin, R.1    Thompson, S.2    Priess, J.R.3
  • 27
    • 0030747773 scopus 로고    scopus 로고
    • Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm
    • Thorpe CJ, Schlesinger A, Carter JC, Bowerman B: Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm. Cell 1997, 90:695-705.
    • (1997) Cell , vol.90 , pp. 695-705
    • Thorpe, C.J.1    Schlesinger, A.2    Carter, J.C.3    Bowerman, B.4
  • 28
    • 0030773708 scopus 로고    scopus 로고
    • Binary specification of the embryonic lineage in Caenorhabditis elegans
    • Kaletta T, Schnabel H, Schnabel R: Binary specification of the embryonic lineage in Caenorhabditis elegans. Nature 1997, 390:294-298.
    • (1997) Nature , vol.390 , pp. 294-298
    • Kaletta, T.1    Schnabel, H.2    Schnabel, R.3
  • 29
    • 0032510020 scopus 로고    scopus 로고
    • Wingless signaling: The inconvenient complexities of life
    • Cox R, Peifer M: Wingless signaling: The inconvenient complexities of life. Curr Biol 1996, 8:140-144.
    • (1996) Curr Biol , vol.8 , pp. 140-144
    • Cox, R.1    Peifer, M.2
  • 30
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: A common theme in animal development
    • Cadigan KM, Nusse R: Wnt signaling: A common theme in animal development. Genes Dev 1997, 11:3286-3305.
    • (1997) Genes Dev , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 31
    • 0032559301 scopus 로고    scopus 로고
    • POP-1 and anterior-posterior fate decision in C. elegans embryos
    • Lin R, Hill R, Priess JR: POP-1 and anterior-posterior fate decision in C. elegans embryos. Cell 1998, 92:229-240. The authors report that AP asymmetries in POP-1 levels occur throughout development, both embryonically and post-embryonically. Reducing pop-1 function not only transforms MS into an E-like fate but also transforms other embryonic cells to the fates of their posterior sisters. Wnt signaling is required in some but not all cases for the regulation of POP-1 levels. As pop-1 is epistatic to lit-1, at least for the E versus MS decision (see [28]), lit-1 may act reiteratively to downregulate POP-1 levels in posterior sisters throughout development, permitting the specification of posterior fates. How lit-1 relates to Wnt signaling awaits its molecular identification.
    • (1998) Cell , vol.92 , pp. 229-240
    • Lin, R.1    Hill, R.2    Priess, J.R.3
  • 32
    • 0023581761 scopus 로고
    • Determination of cell division axes in the early embryogenesis of Caenorhabiditis elegans
    • Hyman AA, White JG: Determination of cell division axes in the early embryogenesis of Caenorhabiditis elegans. J Cell Biol 1987, 105:2123-2135.
    • (1987) J Cell Biol , vol.105 , pp. 2123-2135
    • Hyman, A.A.1    White, J.G.2
  • 33
    • 0027931287 scopus 로고
    • Transient localized accumulation of actin in Caenorhabditis elegans blastomeres with oriented asymmetric divisions
    • Waddle JA, Cooper JA, Waterston RH: Transient localized accumulation of actin in Caenorhabditis elegans blastomeres with oriented asymmetric divisions. Development 1994, 120:2317-2328.
    • (1994) Development , vol.120 , pp. 2317-2328
    • Waddle, J.A.1    Cooper, J.A.2    Waterston, R.H.3
  • 34
    • 0032497694 scopus 로고    scopus 로고
    • The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos
    • 0 has not been defined. The sites of polar body extrusion are somewhat variable and hence may not be good candidates for providing functionally comparable remnant sites.
    • (1998) Curr Biol , vol.8 , pp. 1110-1116
    • Skop, A.R.1    White, J.G.2
  • 35
    • 0031954429 scopus 로고    scopus 로고
    • The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo
    • Rose LS, Kemphues KJ: The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo. Development 1997, 125:1337-1346.
    • (1997) Development , vol.125 , pp. 1337-1346
    • Rose, L.S.1    Kemphues, K.J.2
  • 36
    • 0030598875 scopus 로고    scopus 로고
    • G proteins are required for spatial orientation of early cell cleavage in C. elegans embryos
    • Zwaal R, Broeks A, Van M, Groenen J, Plasterk H: G proteins are required for spatial orientation of early cell cleavage in C. elegans embryos. Cell 1996, 86:619-629.
    • (1996) Cell , vol.86 , pp. 619-629
    • Zwaal, R.1    Broeks, A.2    Van, M.3    Groenen, J.4    Plasterk, H.5
  • 37
    • 0029836212 scopus 로고    scopus 로고
    • A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans
    • Guo S, Kemphues K Jnr: A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans. Nature 1996, 382:455-458.
    • (1996) Nature , vol.382 , pp. 455-458
    • Guo, S.1    Kemphues K., Jnr.2
  • 38
    • 0031818091 scopus 로고    scopus 로고
    • Cyk-1: A C. elegans gene required for a late step in embryonic cytokinesis
    • Swan K, Severson A, Carter J, Martin P, Schnabel H, Schabel R, Bowerman B: Cyk-1: A C. elegans gene required for a late step in embryonic cytokinesis. J Cell Sci 1998, 111:2017-2027. The authors identify a formin protein required for cytokinesis. Cleavage furrows form and ingress partially in cyk-1 mutant embryos, but invariably regress without completing cytokinesis. The CYK-1 protein localizes as a ring to the leading edge of the cleavage furrow but becomes detectable only after substantial furrow ingression. The three mutant alleles identified all have lesions near the 3′ end of the protein coding sequences and may not completely eliminate cyk-1 gene function.
    • (1998) J Cell Sci , vol.111 , pp. 2017-2027
    • Swan, K.1    Severson, A.2    Carter, J.3    Martin, P.4    Schnabel, H.5    Schabel, R.6    Bowerman, B.7
  • 39
    • 0031877351 scopus 로고    scopus 로고
    • Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4
    • See annotation [40•]
    • Raich WB, Moran AN, Rothman JH, Hardin J: Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4. Mol Biol Cell 1998, 9:2037-2049. See annotation [40•].
    • (1998) Mol Biol Cell , vol.9 , pp. 2037-2049
    • Raich, W.B.1    Moran, A.N.2    Rothman, J.H.3    Hardin, J.4
  • 40
    • 0032497690 scopus 로고    scopus 로고
    • A nematode kinesin required for cleavage furrow advancement
    • Powers J, Bossinger O, Rose D, Strome S, Saxton W: A nematode kinesin required for cleavage furrow advancement. Curr Biol 1998, 8: 1133-1136. These two papers use germline clones of a null allele, and RNA interference, to implicate a kinesin called ZEN-4 in cytokinesis. ZEN-4 localizes to interzone microtubules during mitosis and to the leading edge of the cleavage furrow late in cytokinesis, persisting in the remnants left after the completion of cytokinesis. The late defect in cytokinesis observed in these mutant embryos suggests that interactions between the cleavage furrow/contractile ring and the spindle midzone/midbody may be essential for late steps in cytokinesis. As with cyk-1 mutants, zen-4 also is required for polar body extrusion during meiosis.
    • (1998) Curr Biol , vol.8 , pp. 1133-1136
    • Powers, J.1    Bossinger, O.2    Rose, D.3    Strome, S.4    Saxton, W.5
  • 41
    • 0032517860 scopus 로고    scopus 로고
    • AIR-2: An aurora/lpl1 related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos
    • Schumacher JM, Golden A, Donovan P: AIR-2: An aurora/lpl1 related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos. J Cell Biol 1998, 143:1635-1646. The authors use RNA interference to show that an Aurora kinase relative in C. elegans called AIR-2 is required for cytokinesis during both meiosis and mitosis. The AIR-2 protein associates with chromosomes during meiosis and mitosis. It remains associated with the chromosomes in extruded polar bodies and is found on chromosomes at metaphase during mitosis. At metaphase, AIR-2 moves to midbody microtubules and persists at the cytokinesis remnant. As with ZEN-4, these findings point towards interesting interactions between the cell cortex and the spindle midbody during cytokinesis.
    • (1998) J Cell Biol , vol.143 , pp. 1635-1646
    • Schumacher, J.M.1    Golden, A.2    Donovan, P.3
  • 42
    • 0033602489 scopus 로고    scopus 로고
    • Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis
    • Fraser A, James C, Evan G, Hengartner M: Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis. Curr Biol 1999, 9:292-301. The authors use RNA interference to show that a C. elegans BIR repeat protein (similar to inhibitor of apoptosis proteins in vertebrates) called BIR-1 is required, surprisingly, for a late step in cytokinesis without having any apparent role in programmed cell death. A human homolog called survivin partially rescues the defect in embryos lacking BIR-1, suggesting a conserved function during cytokinesis for these proteins.
    • (1999) Curr Biol , vol.9 , pp. 292-301
    • Fraser, A.1    James, C.2    Evan, G.3    Hengartner, M.4
  • 43
    • 0342288145 scopus 로고    scopus 로고
    • Dissection of cell division processes in the one cell stage Caenorhabditis elegans embryo by mutational analysis
    • Gonczy P, Schnabel H, Kaletta T, Amores AD, Hyman T, Schnabel R: Dissection of cell division processes in the one cell stage Caenorhabditis elegans embryo by mutational analysis. J Cell Biol 1999, 144:927-946. This paper reports early cell division defects in a large collection of maternal-effect mutants. The mutants were isolated solely on their embryonic lethality, without any bias for specific mutant phenotypes. These results, from a collection of mutations that map to Chromosome III, clearly illustrate the emergence of C. elegans as an exciting and powerful genetic system in which to study cell division in a developing animal embryo.
    • (1999) J Cell Biol , vol.144 , pp. 927-946
    • Gonczy, P.1    Schnabel, H.2    Kaletta, T.3    Amores, A.D.4    Hyman, T.5    Schnabel, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.