Reduced adrenomedullin expression in gastric mucosa of portal hypertensive rats after ethanol-induced injury

Annals of Surgery

Volumn 230, Issue 1, 1999, Pages 38-44

  Tomikawa, Morimasa ^a   Wang, Hongtao ^a   Jones, Michael K ^a   Sugimachi, Keizo ^b   Sarfeh, I James ^a   Tarnawski, Andrzej S ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; ALCOHOL; MESSENGER RNA; RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MICROVASCULATURE; NONHUMAN; PORTAL HYPERTENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; STOMACH INJURY; STOMACH MUCOSA; TISSUE REPAIR;

ADRENOMEDULLIN; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; ETHANOL; GASTRIC MUCOSA; HYPERTENSION, PORTAL; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0033497439     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-199907000-00006     Document Type: Article

References (23)

1. Kitamura K, Kangawa K, Kawamoto M, et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993; 192:553-560.
2. Sakata J, Shimokubo T, Kitamura K, et al. Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide. Biochem Biophys Res Commun 1993; 195:921-927.
3. Zhao Y, Hague S, Manek S, et al. PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium. Oncogene 1998; 16:409-415.
4. Szabo S, Trier JS, Brown A, Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 1985; 88:228-236.
5. Tarnawski A, Hollander D, Stachura J. Ultrastructural changes in the gastric mucosal microvessels after ethanol. Gastroenterol Clin Biol 1985; 9:93-97.
6. Masuda E, Kawano S, Nagano K, et al. Role of endogenous endothelin in pathogenesis of ethanol-induced gastric mucosal injury in rats. Am J Physiol 1993; 265:G474-G481.
7. Tarnawski A, Stachura J, Gergely H, Hollander D. Microvascular endothelium: a major target for alcohol injury in the human gastric mucosa. J Clin Gastroenterol 1988; 10:554-564.
8. Tarnawski A, Hollander D, Stachura J, et al. Prostaglandin protection of the gastric mucosa against alcohol injury - a dynamic time-related process: the role of mucosal proliferative zone. Gastroenterology 1985; 88:334-352.
9. Tarnawski A, Santos AM, Ichikawa Y, et al. Antacid talcid stimulates angiogenesis in injured gastric mucosa. Eur J Gastroenterol Hepatol 1993; 5:S125-S132.
10. Ichikawa Y, Tarnawski A, Sarfeh IJ, et al. Distorted microangioarchitecture and impaired angiogenesis in gastric mucosa of portal hypertensive rats. Gastroenterology 1994; 106:702-708.
11. Sarfeh IJ, Tarnawski A, Malki A, et al. Portal hypertension and gastric mucosal injury in rats. Effects of alcohol. Gastroenterology 1983; 84:987-993.
12. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-159.
13. Ohta M, Tanoue K, Tarnawski AS, et al. Overexpressed nitric oxide synthase in portal-hypertensive stomach of rat: a key to increased susceptibility to damage? Gastroenterology 1997; 112:1920-1930.
14. Tanoue K, Ohta M, Tarnawski A, et al. Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats. Gastroenterology 1996; 110:549-557.
15. Sun B, Wells J, Goldmuntz E, et al. A simplified, competitive RT-PCR method for measuring rat IFN-γ mRNA expression. J Immunol Methods 1996; 195:139-148.
16. Smith PK, Krohn RI, Hermanson GT, et al. Measurement of protein using bicinchoninic acid. Anal Biochem 1985; 150:76-85.
17. Levy-Toledano R, Caro LH, Hindman N, Taylor SI. Streptavidine blotting: a sensitive technique to study cell surface proteins; application to investigate autophosphorylation and endocytosis of biotin-labeled insulin receptors. Endocrinology 1993; 133:1803-1808.
18. Guevara M, Ginès P, Jimènez W, et al. Increased adrenomedullin levels in cirrhosis: relationship with hemodynamic abnormalities and vasoconstrictor systems. Gastroenterology 1998; 114:336-343.
19. Tomikawa M, Wang H, Jones MK, et al. Expression of adrenomedullin in portal hypertensive gastric mucosa of rats. J Physiol Pharmacol 1998; 49:319-328.
20. Tsuji S, Kawano S, Tsujii M, et al. Roles of hepatocyte growth factor and its receptor in gastric mucosa. A cell biological and molecular biological study. Dig Dis Sci 1995; 40:1132-1139.
21. Szabo S, Goldberg I. Experimental pathogenesis: drugs and chemical lesions in the gastric mucosa. Scand J Gastroenterol (Suppl) 1990; 174:1-8.
22. Withers DJ, Coppock HA, Seufferlein T, et al. Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells. FEBS Lett 1996; 378:83-87.
23. Pai R, Ohta M, Itani RM, et al. Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats. Gastroenterology 1998; 114:706-713.