Expression of adrenomedullin in portal hypertensive gastric mucosa of rats

Journal of Physiology and Pharmacology

Volumn 49, Issue 2, 1998, Pages 319-328

  Tomikawa, M ^a,b   Wang, H ^a,b   Jones, M K ^a,b   Sugimachi, K ^c   Sarfeh, I J ^a,b   Tarnawski, A S ^a,b,d  

^a Departments of Medicine and Surgery   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KYUSHU UNIVERSITY   (Japan)

^d VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

Adrenomedullin; Gastric mucosa; Portal hypertension

Indexed keywords

ADRENOMEDULLIN; DNA; MESSENGER RNA; PROTEIN; RECEPTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; NONHUMAN; PORTAL HYPERTENSION; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH MUCOSA;

ADRENOMEDULLIN; ANIMALS; BLOTTING, WESTERN; GASTRIC MUCOSA; HYPERTENSION, PORTAL; IN SITU HYBRIDIZATION; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0031849261     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Kitamura K, Kangawa K, Kawamoto M et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993; 192: 553-560.
2. Sakata J, Shimokubo T, Kitamura K et al. Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide. Biochem Biophys Res Commun 1993; 195: 921-927.
3. Sugo S, Minamino N, Kangawa K et al. Endothelial cells actively synthesize and secrete adrenomedullin. Biochem Biophys Res Commun 1994; 201: 1160-1166.
4. Sugo S, Minamino N, Shoji H et al. Production and secretion of adrenomedullin from vascular smooth muscle cells: augmented production by tumor necrosis factor-alpha. Biochem Biophys Res Commun 1994; 203: 719-726.
5. Eguchi S, Hirata Y, Kano H et al. Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells. FEBS Lett 1994; 340: 226-230.
6. Ishizaka Y, Tanaka M, Kitamura K et al. Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells. Biochem Biophys Res Commun 1994; 200: 642-646.
7. Imai T, Hirata Y, Iwashina M, Marumo F. Hormonal regulation of rat adrenomedullin gene in vasculature. Endocrinology 1995; 136: 1544-1548.
8. Guth PH, Leung FW. Physiology of the gastric circulation. In: Physiology of the Gastrointestinal Tract. LR Johnson. (ed) 2nd Ed. New York, Raven Press. Vol. 1 1987, pp. 1031 -1053.
9. Kangawa K, Kitamura K, Minamino N, Eto T, Matsuo H. Adrenomedullin: a new hypotensive peptide. J Hypertension Suppl. 1996; 14 (5): S105-S110.
10. Sarfeh IJ, Tarnawski A, Malki A, Mason GR, Mach T, Ivey K. Portal hypertension and gastric mucosal injury in rats. Effects of alcohol. Gastroenterology 1983; 84: 987-993.
11. Sarfeh IJ, Tarnawski A, Hajduczek A, Stachura J, Bui HX, Krause WJ. The portal hypertensive gastric mucosa: histologic, ultrastructural, and functional analysis after aspirin induced damage. Surgery 1988; 104: 79-85.
12. Sarfeh IJ, Soliman H, Waxman K et al. Impaired oxygenation of gastric mucosa in portal hypertension: the basis for increased susceptibility to injury. Dig Dis Sci 1989; 34: 225-228.
13. Arakawa T, Tarnawski A, Mach T, Kobayashi TK, Sarfeh IJ. Impaired generation of prostaglandins from isolated gastric surface epithelial cells in portal hypertensive rats. Prostaglandins 1990; 40: 373-382.
14. Ishikawa T, Sarfeh IJ, Tarnawski A, Golshan R, Douglas T, Sugiyama M. Epidermal growth factor protects portal hypertensive gastric mucosa against ischemia/reperfusion: the role of capillary endothelia and prostaglandins. Surgery 1992; 112: 341-346.
15. Tarnawski A, Sarfeh IJ, Stachura J et al. Microvascular abnormalities of the portal hypertensive gastric mucosa. Hepatology 1988; 8: 1488-1494.
16. Ichikawa Y, Tarnawski A, Sarfeh IJ, Ishikawa T, Shimada H. Distorted microangioarchitecture and impaired angiogenesis in gastric mucosa of portal hypertensive rats. Gastroenterology 1994; 106: 702-708.
17. Ohta M, Tanoue K, Tarnawski AS et al. Overcxpressed nitric oxide synthase in portal-hypertensive stomach of rat: a key to increased susceptibility to damage? Gastroenterology 1997; 112: 1920-1930.
18. Ohta M, Nguyen TH, Tarnawski AS et al. Overexpression of endothelin-1 mRNA and protein in portal hypertensive gastric mucosa of rats: a key to increased susceptibility to damage? Surgery 1997; 122: 936-942.
19. Guevara M, Ginès P, Jimènez W et al. Increased adrenomedullin levels in cirrhosis: relationship with hemodynamic abnormalities and vasoconstrictor systems. Gastroenterology 1998; 114: 336-343.
20. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
21. Tanoue K, Ohta M, Tarnawski AS, Wahlstrom KJ, Sugimachi K, Sarfeh IJ. Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats. Gastroenterology 1996; 110: 549-557.
22. Smith PK, Krohn RI, Hermanson GT et al. Measurement of protein using bicinchoninic acid. Anal Biochem 1985; 150: 76-85.
23. Levy-Toledano R, Caro LH, Hindman N, Taylor SI. Streptavidin blotting: a sensitive technique to study cell surface proteins; application to investigate autophosphorylation and endocytosis of biotin-labeled insulin receptors. Endocrinology 1993; 133: 1803-1808.
24. Washimine H, Asada Y, Kitamura K et al. Immunohistochemical identification of adrenomedullin in human, rat, and porcine tissue. Histochem Cell Biol 1995; 103: 251-254.
25. Mulder H, Ahrén B, Karlsson S, Sundler F. Adrenomedullin: localization in the gastrointestinal tract and effects on insulin secretion. Regul Pept 1996; 62: 107-112.
26. Kitano S, Koyanagi N, Sugimachi K, Kobayashi M, Inokuchi K. Mucosal blood flow and modified vascular responses to norepinephrine in the stomach of rats with liver cirrhosis. Eur Surg Res 1982; 14: 221-230.
27. Vorobioff J, Bredfeldt JE, Groszmann RJ. Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension. Am J Physiol 1983; 244: G52-G57.
28. Piqué JM, Leung FW, Kitahora T, Sarfeh IJ, Tarnawski A, Guth PH. Gastric mucosal blood flow and acid secretion in portal hypertensive rats. Gastroenterology 1988; 95: 727-733.
29. Wallace JL, Chin BC. Inflammatory mediators in gastrointestinal defense and injury. Proc Soc Exp Biol Med 1997; 214: 192-203.