Glycerol production and utilization measured using stable isotopes

Proceedings of the Nutrition Society

Volumn 58, Issue 4, 1999, Pages 973-978

  Landau, Bernard R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glycerol; Lipolysis; Stable isotopes

Indexed keywords

GLYCEROL;

ADIPOSE TISSUE; CONFERENCE PAPER; DIET RESTRICTION; ESTERIFICATION; FATTY ACID METABOLISM; GLYCEROL BLOOD LEVEL; HUMAN; LIPID METABOLISM; LIPOLYSIS;

EID: 0033493620     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0029665199001287     Document Type: Conference Paper

References (40)

1. Ahlborg G & Wahren J (1972) Brain substrate utilization during prolonged exercise. Scandinavian Journal of Clinical and Laboratory Investigation 29, 397-402.
2. Basso LV & Havel RJ (1970) Hepatic metabolism of free fatty acids in normal and diabetic dogs. Journal of Clinical Investigation 49, 5337-5347.
3. Bjorkman O, Eriksson LS, Nyberg B & Wahren J (1990) Gut exchange of glucose and lactate in basal state and after oral glucose ingestion in postoperative patients. Diabetes 39, 747-751.
4. Bonadonna RC, Groop LC, Zych K, Shank M & DeFronzo RA (1990) Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans. American Journal of Physiology 259, E736-E750.
5. Borchgrevink CF & Havel RJ (1963) Transport of glycerol in human blood. Proceedings of the Society for Experimental Biology and Medicine 113, 946-949.
6. Bortz WM, Paul P, Haff AC & Holmes WL (1972) Glycerol turnover and oxidation in man. Journal of Clinical Investigation 51, 1537-1546.
7. Campbell PJ, Carlson MG, Hill JO & Nurjhan N (1992) Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. American Journal of Physiology 263, E1063-E1069.
8. Coppack SW, Jensen MD & Miles JM (1994) In vivo regulation of lipolysis in humans. Journal of Lipid Research 35, 177-193.
9. Coppack SW, Persson M, Judd RL & Miles JM (1999) Glycerol and nonesterified fatty acid metabolism in human muscle and adipose tissue in vivo. American Journal of Physiology 276, E233-E240.
10. DeFreitas AS & Depocas F (1970) Glyceride-glycerol release and the interconversion of glucose and glycerol in normal and fasted rats. Canadian Journal of Physiology and Pharmacology 48, 561-568.
11. Diraison F & Beylot M (1998) Role of human liver reesterification in triglyceride secretion and in FFA reesterification. American Journal of Physiology 274, E321-E327.
12. Elia M, Khan K, Calder G & Kurpad A (1993) Glycerol exchange across the human forearm assessed by a combination of tracer and arteriovenous exchange techniques. Clinical Science 84, 99-104.
13. Frayn KN, Coppack SW & Humphreys SM (1991) Glycerol and lactate uptake in human forearm. Metabolism 40, 1317-1319.
14. Frayn KN, Coppack SW & Humphreys SM (1993) Subcutaneous adipose tissue metabolism studied by local catheterization. international Journal of Obesity and Related Metabolic Disorders 17, S18-S21.
15. Hagenfeldt L & Wahren J (1968) Human forearm metabolism during exercise. Uptake, release and oxidation of individual fatty acids and glycerol. Scandinavian Journal of Clinical and Laboratory Investigation 21, 263-276.
16. Hanson RW, Patel MS, Reshef L & Ballard FJ (1971) The role of pyruvate carboxylase and P-enolpyruvate carboxykinase in adipose tissue. In Regulation of Gluconeogenesis, pp. 255-276 [HD Soling and B Williams, editors]. Stuttgart: G. Theme Verlag.
17. Hellerstein MK, Neese RA & Schwarz J-M (1993) Model for measuring absolute rates of hepatic de novo lipogenesis and reesterification of free fatty acids. American Journal of Physiology 265, E814-E820.
18. Hetenyi G Jr, Perez G & Vranic M (1983) Turnover and precursor-product relationships of nonlipid metabolites. Physiological Reviews 68, 606-667.
19. Jensen MD, Chandramouli V, Schumann WC, Ekberg K, Wahren J & Landau BR (1999) Sources of blood glucose during long term fasting. Diabetes 48, Suppl. 1, A68.
20. Jensen MD & Johnson CM (1996) Contribution of leg and splanchnic free fatty acid (FFA) kinetics to postabsorptive FFA flux in men and women. Metabolism 45, 662-666.
21. Katz J & Wolfe RR (1988) On the measurement of lactate turnover in humans. Metabolism 37, 1078-1080.
22. Klein S, Coppack S, Chinkes D & Villanueva-Meyer J (1996) Regional transendothelial glycerol kinetics in humans. FASEB Journal 10, A520.
23. Klein S, Young VR, Blackburn GL, Bistrian BR & Wolfe RR (1986) Palmitate and glycerol kinetics during brief starvation in normal weight young adult and elderly subjects. Journal of Clinical Investigation 78, 928-933.
24. Kurpad A, Khan K, Calder AG, Coppack S, Frayn K, Macdonald I & Elia M (1994) Effect of noradrenaline on glycerol turnover and lipolysis in the whole body and subcutaneous adipose tissue in humans in vivo. Clinical Science 86, 177-184.
25. Landau BR, Wahren J, Previs SF, Ekberg K, Chandramouli V & Brunengraber H (1996) Glycerol production and utilization in humans: sites and quantitation. American Journal of Physiology 271, E1110-E1117.
26. Larsen JA (1963) Elimination of glycerol as a measure of the hepatic blood flow in the cat. Acta Physiologica Scandinavica 57, 224-234.
27. Newby FD, Wilson LK, Thaker SV & Girolamo M (1990) Adipocyte lactate production remains elevated during refeeding after fasting. American Journal of Physiology 259, E865-E871.
28. 13C]glycerol: role of the infusion-sampling mode. Metabolism 45, 897-901.
29. Previs SF, Fernandez CA, Yang D, Soloviev MV, David F & Brunengraber H (1995) Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis. Substrate cycling between glycerol and triose phosphates in liver. Journal of Biological Chemistry 270, 19806-19815.
30. Previs SF, Martin SK, Hazey JW, Soloviev MV, Keating AP, Lucas D, David F, Koshy J, Kirschenbaum DW, Tserng KY & Brunengraber H (1996) Contributions of liver and kidneys to glycerol production and utilization in the dog. American Journal of Physiology 271, E1118-E1124.
31. Reshef L, Hanson RW & Ballard FJ (1970) A possible physiological role for glyceroneogenesis in rat adipose tissue. Journal of Biological Chemistry 245, 5979-5984.
32. Sacchetti M & van Hall G (1999) Glycerol exchange in human skeletal muscle at rest and during exercise. Proceedings of the Nutrition Society 58, 164A.
33. Samra JS, Clark ML, Humphreys SM, Bannister PA, Summers LKM, MacDonald IA & Frayn KN (1999) Evidence for glycerol uptake by subcutaneous adipose tissue. Proceedings of the Nutrition Society 58, 164A.
34. Thomer JW & Paulus H (1973) Glycerol and glycerate kinases. In The Enzymes, pp. 487-511 [PD Boyer, editor]. New York: Academic Press.
35. Vaughan M & Steinberg D (1965) Glyceride biosynthesis, glyceride breakdown and glycogen breakdown in adipose tissue: mechanisms and regulation. In Handbook of Physiology. Section 5. Adipose Tissue, pp. 239-251 [AE Renold and GF Cahill, editors]. Washington, DC: American Physiological Society.
36. Wasserman DH, Lacy DB, Goldstein RE, Williams PE & Cherrington AD (1989) Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work. Diabetes 38, 484-490.
37. Winkler B, Steele R & Altszuler N ( 1969) Relationship of glycerol uptake to plasma glycerol concentration in the normal dog. American Journal of Physiology 216, 191-196.
38. Wolfe RR (1992a) Radioactive and Stable Isotope Tracers in Biomedicine. New York: Wiley-Liss.
39. Wolfe RR (1992b) Assessment of substrate cycling in humans using tracer methodology. In Energy Metabolism: Tissue Determinants and Cellular Corollaries, pp. 495-524 [J Kinney and HN Tucker, editors]. New York: Raven Press.
40. Wolfe RR, Klein S, Carraro F & Weber J-M (1990) Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise. American Journal of Physiology 258, E382-E389.