Measuring glycerol turnover, gluconeogenesis from glycerol, and total gluconeogenesis with [2-13C]glycerol: Role of the infusion-sampling mode

Metabolism: Clinical and Experimental

Volumn 45, Issue 7, 1996, Pages 897-901

  Peroni, O ^a   Large, V ^a   Odeon, M ^a   Beylot, M ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; GLUCOSE; GLYCEROL;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIABETES MELLITUS; GLUCONEOGENESIS; GLUCOSE METABOLISM; ISOTOPE LABELING; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; VENOUS BLOOD;

EID: 0029979971     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90166-3     Document Type: Article

References (26)

1. 13C nuclear magnetic resonance study. J Clin Invest 90:1323-1327, 1992
2. Weissman C: The metabolic response to stress: An overview and update. Anesthesiology 73:308-327, 1990
3. Laville M, Riou JP, Bougneres P, et al: Glucose metabolism in experimental hyperthyroidism: Intact in vivo sensitivity to insulin with abnormal binding and increased glucose turnover. J Clin Endocrinol Metab 58:960-965, 1984
4. Krebs HA, Hems R, Weidemann J, et al: The fate of isotopic carbon in kidney cortex synthesizing glucose from lactate. Biochem J 101:242-249, 1966
5. Strisower EG, Kohler GD, Chaikoff IL: Incorporation of acetate carbon into glucose by liver slices from normal and alloxan diabetic rats. J Biol Chem 188:115-126, 1952
6. 12C atoms in the pathway of gluconeogenesis in vivo. Fed Proc 41:104-109, 1982
7. 14C labeled substrates. Am J Physiol 248:R331-R339, 1985
8. Kelleher JK: Gluconeogenesis from labeled carbon: Estimating isotopic dilution. Am J Physiol 250:E296-E305, 1986
9. 13C]isocaproate. J Biol Chem 270:1509-1514, 1995
10. 14C]acetate and its use in assessing hepatic Krebs' cycle activity and gluconeogenesis. J Biol Chem 266:6985-6990, 1991
11. Magnusson I, Schumann WC, Bartsch GE, et al: Non invasive tracing of Krebs cycle metabolism in liver. J Biol Chem 266:6975-6984, 1991
12. Nurjhan N, Consoli A, Gerich J: Increased lipolysis and its consequence on gluconeogenesis in non-insulin-dependent diabetes mellitus. J Clin Invest 89:169-175, 1992
13. Large V, Soloviev M, Brunengraber H, et al: Lactate and pyruvate isotopic enrichments in plasma and tissues of post-absorptive and starved rats. Am J Physiol 268:E880-E888, 1995
14. 14C lactate. The significance of tracer administration and sampling. Biochem J 194:513-524, 1981
15. Layman DK, Wolfe RR: Sample site selection for tracer studies applying a non directional approach. Am J Physiol 253:E173-E178, 1987
16. Hellerstein MK, Neese RA: Mass isotopomer distribution analysis: A technique for measuring synthesis and turnover of polymers. Am J Physiol 263:E988-E1001, 1992
17. Lee PWN, Guo Z, Bergner EA: Mass isotopomer pattern and precursor-product relationship. Biol Mass Spectrom 21:114-122, 1992
18. Kelleher JK, Masterson TM: Model equations for condensation biosynthesis using stable isotopes and radioisotopes. Am J Physiol 262:E118-E125, 1992
19. 13C]glycerol and mass isotopomer distribution analysis of glucose. Am J Physiol 269:E516-E523, 1995
20. Neese RA, Schwarz JM, Faix D, et al: Gluconeogenesis and intrahepatic triose phosphate flux in response to fasting or substrate loads. Application of the mass isotopomer distribution analysis technique with testing of assumptions and potential problems. J Biol Chem 279:14452-14663, 1995
21. Beylot M, Martin C, Beaufrere B, et al: Determination in humans of steady state and non steady state glycerol kinetics using deuterium labeled tracer. J Lipid Res 28:414-422, 1987
22. 13C labeling pattern of glucose by gas chromatography-mass spectrometry. Anal Biochem 212:526-531, 1993
23. Katz J, Wolfe RR: On the measurement of lactate turnover in humans. Metabolism 37:1078-1080, 1988
24. Landau BR, Previs SP, Fernandez CA, et al: New aspects of glycerol metabolism. Diabete Metab 21:46A, 1995 (abstr)
25. Landau BR, Fernandez CA, Previs SF, et al: A limitation in the use of mass isotopomer distributions to measure gluconeogenesis in fasting humans. Am J Physiol 269:E18-E26, 1995
26. Previs SF, Fernandez CA, Yang D, et al: Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis. J Biol Chem 270:19806-19815, 1995